CREATINOLFOSFATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H12N3O4P
Molecular Weight	197.1295
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(CCOP(O)(O)=O)C(N)=N

InChI

InChIKey=FOIPWTMKYXWFGC-UHFFFAOYSA-N

InChI=1S/C4H12N3O4P/c1-7(4(5)6)2-3-11-12(8,9)10/h2-3H2,1H3,(H3,5,6)(H2,8,9,10)

HIDE SMILES / InChI

Molecular Formula	C4H12N3O4P
Molecular Weight	197.1295
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6542374 | https://www.ncbi.nlm.nih.gov/pubmed/395957

Creatinolfosfate (or creatinol-O-phosphate, or COP) possesses anti-ischemic and anti-arrhythmic activities associated with improved ionic balance and heart performance. This compound exerts its cardioprotective effect by action on anaerobic glycolysis. The results of the toxicological studies showed that creatinolfosfate didn’t have side effects.

Approval Year

PubMed

Title	Date	PubMed
[Treatment of antihiasthenic syndromes (with creatinol-O-phosphate)].	1976 Sep 30	792963
Protective effect of creatinol O-phosphate (COP) on ventricular fibrillation and death induced by intravenous CaCl2 in mice.	1979	575496
An analysis of the reduction by creatinol O-phosphate of the myocardial lesions evoked by isoprenaline in the rat.	1979	575492
Creatinol O-phosphate therapy in patients with inadequate coronary circulation. Double-blind clinical trial.	1979	395958

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:18:12 GMT 2023` Edited by `admin` on `Fri Dec 15 16:18:12 GMT 2023`
Record UNII	5O564RN1QD
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CREATINOLFOSFATE

Official Name

English

COP

Common Name

English

Creatinolfosfate [WHO-DD]

Common Name

English

CREATINOL O-PHOSPHATE

Common Name

English

creatinolfosfate [INN]

Common Name

English

1-(2-HYDROXYETHYL)-1-METHYLGUANIDINE DIHYDROGEN PHOSPHATE (ESTER)

Common Name

English

Classification Tree Code System Code

DSLD

676 (Number of products:58)