MPTP HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H15N.ClH
Molecular Weight	209.715
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CN1CCC(=CC1)C2=CC=CC=C2

InChI

InChIKey=KOWJANGMTAZWDT-UHFFFAOYSA-N

InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C12H15N
Molecular Weight	173.2542
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Amine oxidase [flavin-containing] B 11 Target ID: P27338 Gene ID: 4129.0 Gene Symbol: MAOB Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/2253761	Substrate 661
Mitochondrial complex I (NADH dehydrogenase) 11 Target ID: CHEMBL2363065 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2253761	Inhibitor 8297
Amine oxidase [flavin-containing] B 11 Target ID: P27338 Gene ID: 4129.0 Gene Symbol: MAOB Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/22281418	Inhibitor 8297

PubMed

Title	Date	PubMed
Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP.	1999 Nov	10591873
Noradrenoceptor antagonism with idazoxan improves L-dopa-induced dyskinesias in MPTP monkeys.	2000 Feb	10685874
Neuroprotective effects of estrogen upon the nigrostriatal dopaminergic system.	2000 May-Jun	11424955
Pharmacological properties of the MPTP analog trans-1-methyl-4-[4-dimethylaminophenylethenyl]-1,2,3,6-tetrahydropyridine and its pyridinium metabolite in mouse brain synaptosomes: a potential visual marker for substrates of MPTP-induced neurotoxicity.	2001 Apr	11370999
Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss.	2001 Apr	11279270
Neuroprotective effects of (+/-)-kavain in the MPTP mouse model of Parkinson's disease.	2001 Apr	11170221
Nuclear factor-kappaB activation is not involved in a MPTP model of Parkinson's disease.	2001 Apr 17	11303744
Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1).	2001 Aug	11509974
Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates.	2001 Aug	11505218
Protection of nigral neurons by GDNF-engineered marrow cell transplantation.	2001 Aug	11463477
Vulnerability of 125I-alpha-conotoxin MII binding sites to nigrostriatal damage in monkey.	2001 Aug 1	11466420
Interactions of 1-methyl-4-phenylpyridinium and other compounds with P-glycoprotein: relevance to toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.	2001 Aug 10	11489261
Nitric oxide enhances MPP(+) inhibition of complex I.	2001 Aug 24	11522295
Group I mGluR antagonist AIDA protects nigral DA cells from MPTP-induced injury.	2001 Aug 28	11522935
[Parkinsonism induced by MPTP and free radical generation].	2001 Feb	11233301
Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism.	2001 Feb	11181820
GDNF reverses priming for dyskinesia in MPTP-treated, L-DOPA-primed common marmosets.	2001 Feb	11168568
Antiparkinsonian and behavioral effects of inactivation of the substantia nigra pars reticulata in hemiparkinsonian primates.	2001 Feb	11161630
Effects of acute and repeated treatment with a novel dopamine D2 receptor ligand on L-DOPA-induced dyskinesias in MPTP monkeys.	2001 Feb 2	11166288
Nicotine, but not cotinine, partially protects dopaminergic neurons against MPTP-induced degeneration in mice.	2001 Feb 2	11164803
Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production.	2001 Feb 2	11163297
SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity.	2001 Feb 23	11172770
Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.	2001 Jan	11208927
Group II metabotropic glutamate receptor activation protects striatal dopaminergic nerve terminals against MPP+-induced neurotoxicity along with brain-derived neurotrophic factor induction.	2001 Jan	11208898
Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP.	2001 Jan	11161607
Glial cell line-derived neurotrophic factor concentration dependently improves disability and motor activity in MPTP-treated common marmosets.	2001 Jan 19	11166735
Nicotinamide-N-methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinson's disease.	2001 Jan 26	11154840
[Pathogenesis of idiopathic Parkinson's disease].	2001 Jul	11523160
Idazoxan, an alpha-2 antagonist, and L-DOPA-induced dyskinesias in patients with Parkinson's disease.	2001 Jul	11481696
Neural mechanisms underlying peak-dose dyskinesia induced by levodopa and apomorphine are distinct: evidence from the effects of the alpha(2) adrenoceptor antagonist idazoxan.	2001 Jul	11481687
Expression of striatal preprotachykinin mRNA in symptomatic and asymptomatic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-exposed monkeys is related to parkinsonian motor signs.	2001 Jul 1	11425917
Rescue of dying neurons by (R)-deprenyl in the MPTP-mouse model of Parkinson's disease does not include restoration of neostriatal dopamine.	2001 Jun	11462789
Parkinson's disease--redox mechanisms.	2001 Jun	11375751
Differential regulation of striatal G protein levels following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration in C57 BL/6 mice.	2001 Jun 22	11403948
Toxic effects of MPP(+) and MPTP in PC12 cells independent of reactive oxygen species formation.	2001 Jun 29	11423095
Reliability and validity of a new global dyskinesia rating scale in the MPTP-lesioned non-human primate.	2001 Mar	11295771
Caspase-3 activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice.	2001 Mar	11295768
The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety.	2001 Mar	11238711
Evidence for a dissociation between MPTP toxicity and tyrosinase activity based on congenic mouse strain susceptibility.	2001 Mar	11170726
Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease.	2001 Mar 1	11223915
Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice.	2001 May	11359883
Caffeine reverses the memory disruption induced by intra-nigral MPTP-injection in rats.	2001 May 1	11427344
Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.	2001 May 15	11319241
Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of parkinson's disease.	2001 May-Aug	11351130
Molecular neurotoxicological models of Parkinsonism: focus on genetic manipulation of mice.	2001 Oct	11489672
Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity.	2001 Oct 26	11509577
Memory disruption in rats with nigral lesions induced by MPTP: a model for early Parkinson's disease amnesia.	2001 Sep 28	11423161

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:15:42 GMT 2023` Edited by `admin` on `Sat Dec 16 08:15:42 GMT 2023`
Record UNII	5O1K9K2EZM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MPTP HYDROCHLORIDE

Common Name

English

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE

Systematic Name

English

PYRIDINE, 1,2,3,6-TETRAHYDRO-1-METHYL-4-PHENYL-, HYDROCHLORIDE (1:1)

Systematic Name

English

Code System Code Type Description

FDA UNII

5O1K9K2EZM