Details
Stereochemistry | ACHIRAL |
Molecular Formula | C12H15N.ClH |
Molecular Weight | 209.715 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CN1CCC(=CC1)C2=CC=CC=C2
InChI
InChIKey=KOWJANGMTAZWDT-UHFFFAOYSA-N
InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C12H15N |
Molecular Weight | 173.2542 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P27338 Gene ID: 4129.0 Gene Symbol: MAOB Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/2253761 |
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Target ID: CHEMBL2363065 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2253761 |
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Target ID: P27338 Gene ID: 4129.0 Gene Symbol: MAOB Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/22281418 |
PubMed
Title | Date | PubMed |
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Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. | 1999 Nov |
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Noradrenoceptor antagonism with idazoxan improves L-dopa-induced dyskinesias in MPTP monkeys. | 2000 Feb |
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Neuroprotective effects of estrogen upon the nigrostriatal dopaminergic system. | 2000 May-Jun |
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Pharmacological properties of the MPTP analog trans-1-methyl-4-[4-dimethylaminophenylethenyl]-1,2,3,6-tetrahydropyridine and its pyridinium metabolite in mouse brain synaptosomes: a potential visual marker for substrates of MPTP-induced neurotoxicity. | 2001 Apr |
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Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss. | 2001 Apr |
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Neuroprotective effects of (+/-)-kavain in the MPTP mouse model of Parkinson's disease. | 2001 Apr |
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Nuclear factor-kappaB activation is not involved in a MPTP model of Parkinson's disease. | 2001 Apr 17 |
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Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1). | 2001 Aug |
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Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates. | 2001 Aug |
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Protection of nigral neurons by GDNF-engineered marrow cell transplantation. | 2001 Aug |
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Vulnerability of 125I-alpha-conotoxin MII binding sites to nigrostriatal damage in monkey. | 2001 Aug 1 |
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Interactions of 1-methyl-4-phenylpyridinium and other compounds with P-glycoprotein: relevance to toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. | 2001 Aug 10 |
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Nitric oxide enhances MPP(+) inhibition of complex I. | 2001 Aug 24 |
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Group I mGluR antagonist AIDA protects nigral DA cells from MPTP-induced injury. | 2001 Aug 28 |
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[Parkinsonism induced by MPTP and free radical generation]. | 2001 Feb |
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Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism. | 2001 Feb |
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GDNF reverses priming for dyskinesia in MPTP-treated, L-DOPA-primed common marmosets. | 2001 Feb |
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Antiparkinsonian and behavioral effects of inactivation of the substantia nigra pars reticulata in hemiparkinsonian primates. | 2001 Feb |
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Effects of acute and repeated treatment with a novel dopamine D2 receptor ligand on L-DOPA-induced dyskinesias in MPTP monkeys. | 2001 Feb 2 |
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Nicotine, but not cotinine, partially protects dopaminergic neurons against MPTP-induced degeneration in mice. | 2001 Feb 2 |
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Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production. | 2001 Feb 2 |
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SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. | 2001 Feb 23 |
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Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. | 2001 Jan |
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Group II metabotropic glutamate receptor activation protects striatal dopaminergic nerve terminals against MPP+-induced neurotoxicity along with brain-derived neurotrophic factor induction. | 2001 Jan |
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Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP. | 2001 Jan |
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Glial cell line-derived neurotrophic factor concentration dependently improves disability and motor activity in MPTP-treated common marmosets. | 2001 Jan 19 |
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Nicotinamide-N-methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinson's disease. | 2001 Jan 26 |
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[Pathogenesis of idiopathic Parkinson's disease]. | 2001 Jul |
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Idazoxan, an alpha-2 antagonist, and L-DOPA-induced dyskinesias in patients with Parkinson's disease. | 2001 Jul |
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Neural mechanisms underlying peak-dose dyskinesia induced by levodopa and apomorphine are distinct: evidence from the effects of the alpha(2) adrenoceptor antagonist idazoxan. | 2001 Jul |
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Expression of striatal preprotachykinin mRNA in symptomatic and asymptomatic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-exposed monkeys is related to parkinsonian motor signs. | 2001 Jul 1 |
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Rescue of dying neurons by (R)-deprenyl in the MPTP-mouse model of Parkinson's disease does not include restoration of neostriatal dopamine. | 2001 Jun |
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Parkinson's disease--redox mechanisms. | 2001 Jun |
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Differential regulation of striatal G protein levels following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration in C57 BL/6 mice. | 2001 Jun 22 |
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Toxic effects of MPP(+) and MPTP in PC12 cells independent of reactive oxygen species formation. | 2001 Jun 29 |
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Reliability and validity of a new global dyskinesia rating scale in the MPTP-lesioned non-human primate. | 2001 Mar |
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Caspase-3 activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. | 2001 Mar |
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The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety. | 2001 Mar |
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Evidence for a dissociation between MPTP toxicity and tyrosinase activity based on congenic mouse strain susceptibility. | 2001 Mar |
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Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease. | 2001 Mar 1 |
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Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice. | 2001 May |
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Caffeine reverses the memory disruption induced by intra-nigral MPTP-injection in rats. | 2001 May 1 |
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Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease. | 2001 May 15 |
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Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of parkinson's disease. | 2001 May-Aug |
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Molecular neurotoxicological models of Parkinsonism: focus on genetic manipulation of mice. | 2001 Oct |
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Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity. | 2001 Oct 26 |
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Memory disruption in rats with nigral lesions induced by MPTP: a model for early Parkinson's disease amnesia. | 2001 Sep 28 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:15:42 GMT 2023
by
admin
on
Sat Dec 16 08:15:42 GMT 2023
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Record UNII |
5O1K9K2EZM
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Record Status |
Validated (UNII)
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Record Version |
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5O1K9K2EZM
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MPTP hydrochloride
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23007-85-4
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161406
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DTXSID5044077
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |