| Stereochemistry | RACEMIC |
| Molecular Formula | C15H12O3 |
| Molecular Weight | 240.254 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=CC=C(C=C1)C2CC(=O)C3=CC=CC=C3O2
InChI
InChIKey=ZLHVIYHWWQYJID-UHFFFAOYSA-N
InChI=1S/C15H12O3/c16-11-7-5-10(6-8-11)15-9-13(17)12-3-1-2-4-14(12)18-15/h1-8,15-16H,9H2
| Molecular Formula | C15H12O3 |
| Molecular Weight | 240.254 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
4’-Hydroxyflavanone is a flavonoid that can be found naturally in parsley, onions, berries, tea, and citrus fruits. 4-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis, and 4-Hydroxyflavanone may have major potential as a pharmaceutical preparation against hepatic steatosis and dyslipidemia.
Originator
Approval Year
PubMed
Patents
Sample Use Guides
Test compounds (4-Hydroxyflavanone) were first assayed at 10 mkM for intrinsic activity using the [35S]GTP-gamma-S binding assay and CHO cell membrane homogenates that express the human muOR, deltaOR, or kappaOR. The subtype selective agonists (D-Ala2,MePhe4,Gly-ol5)enkephalin (DAMGO, muOR), (D-Pen2,D-Pen5)enkephalin (DPDPE, deltaOR), or U69,593 (kappaOR) were run as positive controls as appropriate. The CHO membranes were incubated in duplicate in 1.4 mL polypropylene tubes (Matrix Technologies, Hudson, NH) with positive control or test compound, 0.1 nM [35S]GTP-gamma-S, and 1 mkM GDP in 50 mM HEPES buffer (pH 7.4) at room temperature for 1 h, after which bound radioligand was separated from free via rapid vacuum filtration over GF-B filters with a Brandel Scientific (Gaithersburg, MD) 96-well harvester. Bound radioactivity was determined using a TopCount 12-detector instrument (Packard Instruments) using standard scintillation counting techniques. The data were normalized to samples containing vehicle (basal binding).