QUINDECAMINE ACETATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C30H38N4.2C2H4O2.2H2O
Molecular Weight	610.784
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.O.CC(O)=O.CC(O)=O.CC1=CC(NCCCCCCCCCCNC2=CC(C)=NC3=C2C=CC=C3)=C4C=CC=CC4=N1

InChI

InChIKey=XHJVGKULSGWYHF-UHFFFAOYSA-N

InChI=1S/C30H38N4.2C2H4O2.2H2O/c1-23-21-29(25-15-9-11-17-27(25)33-23)31-19-13-7-5-3-4-6-8-14-20-32-30-22-24(2)34-28-18-12-10-16-26(28)30;2*1-2(3)4;;/h9-12,15-18,21-22H,3-8,13-14,19-20H2,1-2H3,(H,31,33)(H,32,34);2*1H3,(H,3,4);2*1H2

HIDE SMILES / InChI

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C30H38N4
Molecular Weight	454.6495
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C2H4O2
Molecular Weight	60.052
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10742299 | https://www.ncbi.nlm.nih.gov/pubmed/4569086

Quindecamine (also known as UCL-1407) is quinaldine derivative with antibiotic and fungicidal activity. Treatment of rats and mice with Quindecamine (250 mg/kg/ day) each day for 4 weeks followed by 500 mg/kg/day for 2 more weeks reduced spontaneous motility and body weight but produced no pathological abnormalities of the various organs studied. In vitro, the drug showed very good activity against Staphylococcus aureus, Streptococcus hemolyticus, Candida albicans, Trichophyton mentagrophytes, and T. vaginalis. The drug had very good activity in 180 human subjects with various bacterial and mycotic diseases of the skin and mucosa when applied as a 1% salve.

Originator

Approval Year

PubMed

Title	Date	PubMed
Compounds that block both intermediate-conductance (IK(Ca)) and small-conductance (SK(Ca)) calcium-activated potassium channels.	2000 Apr	10742299

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:10:37 GMT 2023` Edited by `admin` on `Fri Dec 15 15:10:37 GMT 2023`
Record UNII	5JH93XA08W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

QUINDECAMINE ACETATE

Official Name

English

1,10-DECANEDIAMINE, N,N'-BIS(2-METHYL-4-QUINOLINYL)-, DIACETATE DIHYDRATE

Systematic Name

English

4,4'-(DECAMETHYLENEDIIMINO)DIQUINALDINE DIACETATE DIHYDRATE

Systematic Name

English

RMI 8090DJ

Code

English

RMI-8090DJ

Code

English

QUINDECAMINE ACETATE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C258