SB-332235

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H10Cl3N3O4S
Molecular Weight	410.66
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NS(=O)(=O)C1=C(Cl)C=CC(NC(=O)NC2=C(Cl)C(Cl)=CC=C2)=C1O

InChI

InChIKey=WTLRWOHEKQGKDS-UHFFFAOYSA-N

InChI=1S/C13H10Cl3N3O4S/c14-6-2-1-3-8(10(6)16)18-13(21)19-9-5-4-7(15)12(11(9)20)24(17,22)23/h1-5,20H,(H2,17,22,23)(H2,18,19,21)

HIDE SMILES / InChI

Molecular Formula	C13H10Cl3N3O4S
Molecular Weight	410.66
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Interleukin-8 receptor B 8 Target ID: CHEMBL2434 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27096048	Antagonist 2778		8.7 null [pIC50]

PubMed

Title	Date	PubMed
A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit.	2002 Dec 1	12444152

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:40:33 GMT 2023` Edited by `admin` on `Sat Dec 16 10:40:33 GMT 2023`
Record UNII	5HLP8UVL8M
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SB-332235

Common Name

English

N-(4-CHLORO-2-HYDROXY-3-AMINOSULFONYLPHENYL)-N'-(2,3-DICHLOROPHENYL)UREA

Systematic Name

English

1-(4-CHLORO-2-HYDROXY-3-SULFAMOYL-PHENYL)-3-(2,3-DICHLOROPHENYL)UREA

Systematic Name

English

BENZENESULFONAMIDE, 6-CHLORO-3-((((2,3-DICHLOROPHENYL)AMINO)CARBONYL)AMINO)-2-HYDROXY-

Systematic Name

English

Code System Code Type Description

CAS

276702-15-9

Created by admin on Sat Dec 16 10:40:33 GMT 2023 , Edited by admin on Sat Dec 16 10:40:33 GMT 2023

PRIMARY

PUBCHEM

9887803

Created by admin on Sat Dec 16 10:40:33 GMT 2023 , Edited by admin on Sat Dec 16 10:40:33 GMT 2023

PRIMARY

FDA UNII

5HLP8UVL8M

Created by admin on Sat Dec 16 10:40:33 GMT 2023 , Edited by admin on Sat Dec 16 10:40:33 GMT 2023

PRIMARY

MANUFACTURER PRODUCT INFORMATION

SB-332235

Created by admin on Sat Dec 16 10:40:33 GMT 2023 , Edited by admin on Sat Dec 16 10:40:33 GMT 2023

PRIMARY

Class: Small molecule; Mechanism of Action: Interleukin 8 receptor antagonist; Highest Development Phase: Discontinued for Chronic obstructive pulmonary disease and Psoriasis

Related Record Type Details


					I5YP541PHQ

SB-332235 SODIUM

SALT/SOLVATE -> PARENT


					1Q60Y7B2ET

SB-332235 POTASSIUM

SALT/SOLVATE -> PARENT

Related Record Type Details


					5HLP8UVL8M

SB-332235

ACTIVE MOIETY

Comments:

Description: SB-332235 is a potent and specific CXCR2 antagonist. SB-332235 effectively inhibited CS-induced neutrophilia in a dose-dependent manner. (last updated: 2/11/2016).