NF-KAPPA-B P65-P50 COMPLEX

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 05:34:24 GMT 2025` Edited by `admin` on `Wed Apr 02 05:34:24 GMT 2025`
Protein Type	TRANSCRIPTION FACTOR
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	5GAV4KY0LX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NF-.KAPPA.-B P65-P50 COMPLEX

Preferred Name

English

NF-KAPPA-B P65-P50 COMPLEX

Common Name

English

Code System Code Type Description

UNIPROT

Q04206

Created by admin on Wed Apr 02 05:34:24 GMT 2025 , Edited by admin on Wed Apr 02 05:34:24 GMT 2025

PRIMARY

UNIPROT

P19838

Created by admin on Wed Apr 02 05:34:24 GMT 2025 , Edited by admin on Wed Apr 02 05:34:24 GMT 2025

PRIMARY

FDA UNII

5GAV4KY0LX

Created by admin on Wed Apr 02 05:34:24 GMT 2025 , Edited by admin on Wed Apr 02 05:34:24 GMT 2025

PRIMARY

Related Record Type Details


					4GUY9L896T

HELENALIN

INHIBITOR -> TARGET

Comments:

Helenalin selectively alkylates p65 subunit at Cys38 [27, 63]. Formation of this covalent bond sterically prevents the p50/p65 heterodimer from binding to DNA and therefore inhibits its transcriptional activation.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1]	N-TERMINUS			N-ACETYLMETHIONINE	9J12WX5B6A

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL