U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Wed Apr 02 05:34:24 GMT 2025
Edited
by admin
on Wed Apr 02 05:34:24 GMT 2025
Protein Type TRANSCRIPTION FACTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
5GAV4KY0LX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NF-.KAPPA.-B P65-P50 COMPLEX
Preferred Name English
NF-KAPPA-B P65-P50 COMPLEX
Common Name English
Code System Code Type Description
UNIPROT
Q04206
Created by admin on Wed Apr 02 05:34:24 GMT 2025 , Edited by admin on Wed Apr 02 05:34:24 GMT 2025
PRIMARY
UNIPROT
P19838
Created by admin on Wed Apr 02 05:34:24 GMT 2025 , Edited by admin on Wed Apr 02 05:34:24 GMT 2025
PRIMARY
FDA UNII
5GAV4KY0LX
Created by admin on Wed Apr 02 05:34:24 GMT 2025 , Edited by admin on Wed Apr 02 05:34:24 GMT 2025
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
Helenalin selectively alkylates p65 subunit at Cys38 [27, 63]. Formation of this covalent bond sterically prevents the p50/p65 heterodimer from binding to DNA and therefore inhibits its transcriptional activation.

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_1] N-TERMINUS N-ACETYLMETHIONINE 9J12WX5B6A
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL