HELENALIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C15H18O4
Molecular Weight	262.301
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H](C)[C@]3([H])C=CC(=O)[C@@]3(C)[C@@H](O)[C@]1([H])C(=C)C(=O)O2

InChI

InChIKey=ZVLOPMNVFLSSAA-XEPQRQSNSA-N

InChI=1S/C15H18O4/c1-7-6-10-12(8(2)14(18)19-10)13(17)15(3)9(7)4-5-11(15)16/h4-5,7,9-10,12-13,17H,2,6H2,1,3H3/t7-,9+,10-,12-,13+,15+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C15H18O4
Molecular Weight	262.301
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Inhibition of homodimerization of Toll-like receptor 4 by curcumin.	2006 Jun 28	16678799
Inhibition of Nod2 signaling and target gene expression by curcumin.	2008 Jul	18413660
Overexpression of HO-1 protects against TNF-alpha-mediated airway inflammation by down-regulation of TNFR1-dependent oxidative stress.	2009 Aug	19608869
Helenalin-induced apoptosis is dependent on production of reactive oxygen species and independent of induction of endoplasmic reticulum stress in renal cell carcinoma.	2013 Mar	23123298

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:44:05 GMT 2023` Edited by `admin` on `Fri Dec 15 19:44:05 GMT 2023`
Record UNII	4GUY9L896T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HELENALIN

Common Name

English

6.ALPHA.,8.BETA.-DIHYDROXY-4-OXOAMBROSA-2,11(13)-DIEN-12-OIC ACID 12,8-LACTONE

Common Name

English

(-)-HELENALIN

Common Name

English

HELENALIN [MI]

Common Name

English

HELENALIN [HSDB]

Common Name

English

(3AS-(3A.ALPHA.,4.ALPHA.,4A.BETA.,7A.ALPHA.,8.ALPHA.,9A.ALPHA.))-3,3A,4,4A,7A,8,9,9A-OCTAHYDRO-4-HYDROXY-4A,8-DIMETHYL-3-METHYLENEAZULENO(6,5-B)FURAN-2,5-DIONE

Common Name

English

NSC-85236

Code

English

Code System Code Type Description

HSDB

3490