FLUTAZOLAM

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H18ClFN2O3
Molecular Weight	376.809
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCN1C2=CC=C(Cl)C=C2C3(OCCN3CC1=O)C4=CC=CC=C4F

InChI

InChIKey=WMFSSTNVXWNLKI-UHFFFAOYSA-N

InChI=1S/C19H18ClFN2O3/c20-13-5-6-17-15(11-13)19(14-3-1-2-4-16(14)21)22(8-10-26-19)12-18(25)23(17)7-9-24/h1-6,11,24H,7-10,12H2

HIDE SMILES / InChI

Molecular Formula	C19H18ClFN2O3
Molecular Weight	376.809
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://med.sawai.co.jp/file/pr22_1083.pdf

Flutazolam is a benzodiazepine derivative developed in Japan by Mitsui. The drug is marketed under the name Coreminal and used for the treatment of gastrointestinal disorders. The mechanism of flutazolam action is due to activation of GABA-A receptors as it has affinity to the benzodiazepine binding sites.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-A receptor; benzodiazepine site 38 Target ID: CHEMBL2109243 Sources: http://med.sawai.co.jp/file/pr22_1083.pdf	Partial Agonist 290

Conditions

Condition	Modality	Targets	Highest Phase	Product
Gastrointestinal disorders 95 Sources: http://med.sawai.co.jp/file/pr22_1083.pdf	Palliative		Approved 8429	COREMINAL Approved Use Unknown

PubMed

Title	Date	PubMed
[Psychopharmacological effects of flutazolam (MS-4101) (author's transl)].	1978 Nov	750333
The behavior of 1,4-benzodiazepine drugs in acidic media. V. Kinetics of hydrolysis of flutazolam and haloxazolam in aqueous solution.	1986 Jan	2870816
[The behavior of 1,4-benzodiazepine drugs in acidic media. IX. Effect of hydrolyzate of flutazolam on the central nervous system].	1987 Oct	2894449
[Studies on the clinical significance concerning the changes in serum pepsinogen-I and gastrin levels in aged patients with chronic gastritis].	1988 Mar	2898425
Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel.	1996 Jun 28	8832439
Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays.	2017 Apr	27366870

Sample Use Guides

In Vivo Use Guide

The usual adult dose is 12 mg administered 3 times/day.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:47:31 UTC 2023` Edited by `admin` on `Fri Dec 15 15:47:31 UTC 2023`
Record UNII	5G2K7O5D8S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUTAZOLAM

Official Name

English

FLUTAZOLAM [MI]

Common Name

English

flutazolam [INN]

Common Name

English

10-CHLORO-11B-(O-FLUOROPHENYL)-2,3,7,11B-TETRAHYDRO-7-(2-HYDROXYETHYL)OXAZOLO(3,2-D)(1,4)BENZODIAZEPIN-6(5H)-ONE

Common Name

English

FLUTAZOLAM [MART.]

Common Name

English

FLUTAZOLAM [JAN]

Common Name

English

COREMINAL

Brand Name

English

Flutazolam [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1012