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Details

Stereochemistry RACEMIC
Molecular Formula C19H18ClFN2O3
Molecular Weight 376.809
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLUTAZOLAM

SMILES

OCCN1C2=CC=C(Cl)C=C2C3(OCCN3CC1=O)C4=CC=CC=C4F

InChI

InChIKey=WMFSSTNVXWNLKI-UHFFFAOYSA-N
InChI=1S/C19H18ClFN2O3/c20-13-5-6-17-15(11-13)19(14-3-1-2-4-16(14)21)22(8-10-26-19)12-18(25)23(17)7-9-24/h1-6,11,24H,7-10,12H2

HIDE SMILES / InChI

Molecular Formula C19H18ClFN2O3
Molecular Weight 376.809
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Flutazolam is a benzodiazepine derivative developed in Japan by Mitsui. The drug is marketed under the name Coreminal and used for the treatment of gastrointestinal disorders. The mechanism of flutazolam action is due to activation of GABA-A receptors as it has affinity to the benzodiazepine binding sites.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
COREMINAL

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[Studies on the clinical significance concerning the changes in serum pepsinogen-I and gastrin levels in aged patients with chronic gastritis].
1988 Mar
Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel.
1996 Jun 28

Sample Use Guides

In Vivo Use Guide
The usual adult dose is 12 mg administered 3 times/day.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:47:31 GMT 2023
Edited
by admin
on Fri Dec 15 15:47:31 GMT 2023
Record UNII
5G2K7O5D8S
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FLUTAZOLAM
INN   JAN   MART.   MI   WHO-DD  
INN  
Official Name English
FLUTAZOLAM [MI]
Common Name English
flutazolam [INN]
Common Name English
10-CHLORO-11B-(O-FLUOROPHENYL)-2,3,7,11B-TETRAHYDRO-7-(2-HYDROXYETHYL)OXAZOLO(3,2-D)(1,4)BENZODIAZEPIN-6(5H)-ONE
Common Name English
FLUTAZOLAM [MART.]
Common Name English
FLUTAZOLAM [JAN]
Common Name English
COREMINAL
Brand Name English
Flutazolam [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1012
Created by admin on Fri Dec 15 15:47:31 GMT 2023 , Edited by admin on Fri Dec 15 15:47:31 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL1697836
Created by admin on Fri Dec 15 15:47:31 GMT 2023 , Edited by admin on Fri Dec 15 15:47:31 GMT 2023
PRIMARY
MERCK INDEX
m1171
Created by admin on Fri Dec 15 15:47:31 GMT 2023 , Edited by admin on Fri Dec 15 15:47:31 GMT 2023
PRIMARY Merck Index
EVMPD
SUB07757MIG
Created by admin on Fri Dec 15 15:47:31 GMT 2023 , Edited by admin on Fri Dec 15 15:47:31 GMT 2023
PRIMARY
FDA UNII
5G2K7O5D8S
Created by admin on Fri Dec 15 15:47:31 GMT 2023 , Edited by admin on Fri Dec 15 15:47:31 GMT 2023
PRIMARY
NCI_THESAURUS
C65737
Created by admin on Fri Dec 15 15:47:31 GMT 2023 , Edited by admin on Fri Dec 15 15:47:31 GMT 2023
PRIMARY
INN
3682
Created by admin on Fri Dec 15 15:47:31 GMT 2023 , Edited by admin on Fri Dec 15 15:47:31 GMT 2023
PRIMARY
DRUG CENTRAL
1224
Created by admin on Fri Dec 15 15:47:31 GMT 2023 , Edited by admin on Fri Dec 15 15:47:31 GMT 2023
PRIMARY
SMS_ID
100000080955
Created by admin on Fri Dec 15 15:47:31 GMT 2023 , Edited by admin on Fri Dec 15 15:47:31 GMT 2023
PRIMARY
PUBCHEM
3398
Created by admin on Fri Dec 15 15:47:31 GMT 2023 , Edited by admin on Fri Dec 15 15:47:31 GMT 2023
PRIMARY
WIKIPEDIA
Flutazolam
Created by admin on Fri Dec 15 15:47:31 GMT 2023 , Edited by admin on Fri Dec 15 15:47:31 GMT 2023
PRIMARY
MESH
C013367
Created by admin on Fri Dec 15 15:47:31 GMT 2023 , Edited by admin on Fri Dec 15 15:47:31 GMT 2023
PRIMARY
EPA CompTox
DTXSID6023072
Created by admin on Fri Dec 15 15:47:31 GMT 2023 , Edited by admin on Fri Dec 15 15:47:31 GMT 2023
PRIMARY
CAS
27060-91-9
Created by admin on Fri Dec 15 15:47:31 GMT 2023 , Edited by admin on Fri Dec 15 15:47:31 GMT 2023
PRIMARY
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