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Details

Stereochemistry RACEMIC
Molecular Formula C19H18ClFN2O3
Molecular Weight 376.809
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLUTAZOLAM

SMILES

OCCN1C2=CC=C(Cl)C=C2C3(OCCN3CC1=O)C4=CC=CC=C4F

InChI

InChIKey=WMFSSTNVXWNLKI-UHFFFAOYSA-N
InChI=1S/C19H18ClFN2O3/c20-13-5-6-17-15(11-13)19(14-3-1-2-4-16(14)21)22(8-10-26-19)12-18(25)23(17)7-9-24/h1-6,11,24H,7-10,12H2

HIDE SMILES / InChI

Molecular Formula C19H18ClFN2O3
Molecular Weight 376.809
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Flutazolam is a benzodiazepine derivative developed in Japan by Mitsui. The drug is marketed under the name Coreminal and used for the treatment of gastrointestinal disorders. The mechanism of flutazolam action is due to activation of GABA-A receptors as it has affinity to the benzodiazepine binding sites.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
COREMINAL

Cmax

ValueDoseCo-administeredAnalytePopulation
0.014 μg/mL
12 mg single, oral
FLUTAZOLAM serum
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
0.068 μg × h/mL
12 mg single, oral
FLUTAZOLAM serum
Homo sapiens

PubMed

Sample Use Guides

In Vivo Use Guide
The usual adult dose is 12 mg administered 3 times/day.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
5G2K7O5D8S
Record Status Validated (UNII)
Record Version