Details
| Stereochemistry | UNKNOWN |
| Molecular Formula | C23H18ClN5O2S |
| Molecular Weight | 462.94 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC=C(C=C1)C2=NN(CC2C3=CC=CC=C3)C(=N)NS(=O)(=O)C4=CC=C(C=C4)[11C]#N
InChI
InChIKey=OQIBXTHHXDTIBJ-UMSOTBISSA-N
InChI=1S/C23H18ClN5O2S/c24-19-10-8-18(9-11-19)22-21(17-4-2-1-3-5-17)15-29(27-22)23(26)28-32(30,31)20-12-6-16(14-25)7-13-20/h1-13,21H,15H2,(H2,26,28)/i14-1
| Molecular Formula | C23H18ClN5O2S |
| Molecular Weight | 462.94 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:23:09 GMT 2023
by
admin
on
Sat Dec 16 09:23:09 GMT 2023
|
| Record UNII |
5E5J7NV163
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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| Code System | Code | Type | Description | ||
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25109915
Created by
admin on Sat Dec 16 09:23:09 GMT 2023 , Edited by admin on Sat Dec 16 09:23:09 GMT 2023
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PRIMARY | |||
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5E5J7NV163
Created by
admin on Sat Dec 16 09:23:09 GMT 2023 , Edited by admin on Sat Dec 16 09:23:09 GMT 2023
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1061091-86-8
Created by
admin on Sat Dec 16 09:23:09 GMT 2023 , Edited by admin on Sat Dec 16 09:23:09 GMT 2023
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SD-5024 C-11
Created by
admin on Sat Dec 16 09:23:09 GMT 2023 , Edited by admin on Sat Dec 16 09:23:09 GMT 2023
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PRIMARY | This study has been terminated.Official Title: PET Imaging of CB1 Receptors Using (11C)SD5024Purpose(Background): The cannabinoid type 1 (CB1) receptor is a protein found on some brain cells. It may play a role in obesity or some psychiatric disorders such as schizophrenia. Imaging studies like positron emission tomography (PET) can show where CB1 receptors are located. A new radioactive chemical, 11C-SD5024, may be able to show these receptors more clearly than previous radioactive chemicals. Better images of CB1 receptors in the brain may help improve our understanding of obesity and psychiatric disorders. This information may lead to better treatments. |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
After injection of (11C)(-)-12a, there was high uptake and retention of radioactivity across brain according to the rank order of CB1 receptor densities. The distomer, (11C)(+)-12a, failed to give a sustained CB1 receptor-specific distribution. Polar radiometabolites of (11C)(-)-12a appeared moderately slowly in plasma. Radioligand (11C)(-)-12a is promising for the study of brain CB1 receptors and merits further investigation in human subjects.
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