SD-5024 C-11

Details

Stereochemistry	UNKNOWN
Molecular Formula	C23H18ClN5O2S
Molecular Weight	462.94
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C(C=C1)C2=NN(CC2C3=CC=CC=C3)C(=N)NS(=O)(=O)C4=CC=C(C=C4)[11C]#N

InChI

InChIKey=OQIBXTHHXDTIBJ-UMSOTBISSA-N

InChI=1S/C23H18ClN5O2S/c24-19-10-8-18(9-11-19)22-21(17-4-2-1-3-5-17)15-29(27-22)23(26)28-32(30,31)20-12-6-16(14-25)7-13-20/h1-13,21H,15H2,(H2,26,28)/i14-1

HIDE SMILES / InChI

Molecular Formula	C23H18ClN5O2S
Molecular Weight	462.94
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:38:19 GMT 2025` Edited by `admin` on `Mon Mar 31 22:38:19 GMT 2025`
Record UNII	5E5J7NV163
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SD-5024 C-11

Code

English

(11C)SD-5024

Preferred Name

English

1H-PYRAZOLE-1-CARBOXIMIDAMIDE, 3-(4-CHLOROPHENYL)-N-((4-(CYANO-11C)PHENYL)SULFONYL)-4,5-DIHYDRO-4-PHENYL-

Systematic Name

English

Code System Code Type Description

PUBCHEM

25109915

Created by admin on Mon Mar 31 22:38:19 GMT 2025 , Edited by admin on Mon Mar 31 22:38:19 GMT 2025

PRIMARY

FDA UNII

5E5J7NV163

Created by admin on Mon Mar 31 22:38:19 GMT 2025 , Edited by admin on Mon Mar 31 22:38:19 GMT 2025

PRIMARY

CAS

1061091-86-8

Created by admin on Mon Mar 31 22:38:19 GMT 2025 , Edited by admin on Mon Mar 31 22:38:19 GMT 2025

PRIMARY

CLINICAL_TRIALS.GOV

SD-5024 C-11

Created by admin on Mon Mar 31 22:38:19 GMT 2025 , Edited by admin on Mon Mar 31 22:38:19 GMT 2025

PRIMARY

This study has been terminated.Official Title: PET Imaging of CB1 Receptors Using (11C)SD5024Purpose(Background): The cannabinoid type 1 (CB1) receptor is a protein found on some brain cells. It may play a role in obesity or some psychiatric disorders such as schizophrenia. Imaging studies like positron emission tomography (PET) can show where CB1 receptors are located. A new radioactive chemical, 11C-SD5024, may be able to show these receptors more clearly than previous radioactive chemicals. Better images of CB1 receptors in the brain may help improve our understanding of obesity and psychiatric disorders. This information may lead to better treatments.

Related Record Type Details


					5E5J7NV163

SD-5024 C-11

ACTIVE MOIETY

Comments:

After injection of (11C)(-)-12a, there was high uptake and retention of radioactivity across brain according to the rank order of CB1 receptor densities. The distomer, (11C)(+)-12a, failed to give a sustained CB1 receptor-specific distribution. Polar radiometabolites of (11C)(-)-12a appeared moderately slowly in plasma. Radioligand (11C)(-)-12a is promising for the study of brain CB1 receptors and merits further investigation in human subjects.