Method of administration Intravenous route: Restricted to children weighing 33 kg or more and to adults. It is recommended to use the product immediately following reconstitution. Do not mix with other drugs because of the risk of incompatibility. Children weighing 33 kg or more Propacetamol is used in infusion over 15 minutes after dilution of the product, using a transfer device, in 5% glucose solution or 0.9% sodium chloride solution. In order to comply with blood volume, the maximum volume which may be infused in children is 1 to 2 ml/kg/injection. The 1 g powder should be dissolved in a 50 ml flexible bag. The 2 g powder should be dissolved in a 100 ml flexible bag. Adults After the product is reconstituted using the transfer device, administration takes place using 5% glucose solution or 0.9% sodium chloride solution (about 100 ml) over 15 minutes. Posology In children the posology is 30 mg/kg per injection, i.e. 1.5 ml/kg per injection of the 1 g solution reconstituted in 50 ml or the 2 g solution reconstituted in 100 ml, to be repeated if necessary after an interval of at least 6 hours, without exceeding the maximum daily posology of 120 mg/kg of propacetamol, i.e. 60 mg/kg of paracetamol. In adults the posology is 1 to 2 g, to be repeated if necessary after an interval of 4 hours, without exceeding 6 g per day, or in exeptional cases, 8 g per day. Frequency of administration Systematic administrations will avoid fluctuations of pain or fever. In children, they must be given at least 6 hours apart. In adults, they must be given at least 4 hours apart.

In hTRPV1-expressing cells 100 uM and higher concentrations activated membrane currents with a strong outward rectification in all cells which also generated capsaicin (1 uM)-induced currents