EPITHIAZIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C10H11ClF3N3O4S3
Molecular Weight	425.855
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NS(=O)(=O)C1=C(Cl)C=C2NC(CSCC(F)(F)F)NS(=O)(=O)C2=C1

InChI

InChIKey=RINBGYCKMGDWPY-UHFFFAOYSA-N

InChI=1S/C10H11ClF3N3O4S3/c11-5-1-6-8(2-7(5)23(15,18)19)24(20,21)17-9(16-6)3-22-4-10(12,13)14/h1-2,9,16-17H,3-4H2,(H2,15,18,19)

HIDE SMILES / InChI

Molecular Formula	C10H11ClF3N3O4S3
Molecular Weight	425.855
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14185229 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1872837/pdf/brmedj02517-0002.pdf

Epithiazide (epithizide) is a diuretic drug. Its combination with Veriloid under the trade name Thiaver was used in the 1960s for the treatment of hypertension.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Thiazide-sensitive sodium-chloride cotransporter 28 Target ID: CHEMBL1876 Sources: https://patents.google.com/patent/WO2014076235A1 \| https://www.ncbi.nlm.nih.gov/pubmed/14185229 \| https://books.google.ru/books?id=rmx2fLEdZvwC&pg=PA217&lpg=PA217&dq=EPITHIAZIDE retrieved from A Manual of Adverse Drug Interactions By J.P. Griffin, P.F. D'Arcy, p. 217	Inhibitor 8297

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:47:50 GMT 2023` Edited by `admin` on `Fri Dec 15 18:47:50 GMT 2023`
Record UNII	5B266B85J1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EPITHIAZIDE

Official Name

English

epitizide [INN]

Common Name

English

EPITHIAZIDE [USAN]

Common Name

English

EPITHIAZIDE [MI]

Common Name

English

FLURESE

Brand Name

English

THIAVER

Brand Name

English

Epitizide [WHO-DD]

Common Name

English

P-2105

Code

English

EPITIZIDE

Official Name

English

6-Chloro-3,4-dihydro-3{[(2,2,2-trifluoroethyl)thio]methyl}-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Systematic Name

English

3-((2,2,2-TRIFLUOROETHYLTHIO)METHYL)-6-CHLORO-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE

Systematic Name

English

NSC-108164

Code

English

EPITIZIDE [MART.]

Common Name

English

Classification Tree Code System Code

WHO-ATC

C03EA03