U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C24H27NO2
Molecular Weight 361.4767
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OCTOCRYLENE

SMILES

CCCCC(CC)COC(=O)C(C#N)=C(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=FMJSMJQBSVNSBF-UHFFFAOYSA-N
InChI=1S/C24H27NO2/c1-3-5-12-19(4-2)18-27-24(26)22(17-25)23(20-13-8-6-9-14-20)21-15-10-7-11-16-21/h6-11,13-16,19H,3-5,12,18H2,1-2H3

HIDE SMILES / InChI
Molecular Formula C24H27NO2
Molecular Weight 361.4767
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment: description was created based on several sources, including, http://onlinelibrary.wiley.com/doi/10.1111/cod.12205/epdf

Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties. What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin damage from prolonged sun exposure. Octocrylene is also often combined with avobenzone, another common sunscreen ingredient often appearing on ingredient labels. Because of its effectiveness, the chemical has been approved across the globe for use in cosmetics and skin care products, but the concentrations of this ingredient are usually limited to no more than 10 or 12 percent. However, the use of this chemical doesn’t just stop with sunscreen for face and arms, but can extend to a variety of other products, like hair spray, tannin oil, BB cream, conditioner, and CC cream, among others. Octocrylene may cause contact and photocontact allergy.

Originator

Gers-Barlag, H.|Miller, A.
1
Curator's Comment: http://143230426296262911.weebly.com/introduction-to-molecule.html

Approval Year

2004
210
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Approved
8429
ANTHELIOS 20

Approved Use

Help prevent sunburns.

Launch Date

2006
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
3.7 ng/mL
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/31058986
2.7 g single, topical
dose: 2.7 g
route of administration: Topical
experiment type: SINGLE
co-administered:
OCTOCRYLENE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
7.8 ng/mL
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/31058986
2.7 g 4 times / day steady-state, topical
dose: 2.7 g
route of administration: Topical
experiment type: STEADY-STATE
co-administered:
OCTOCRYLENE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
43.3 h
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/31058986
2.7 g 4 times / day steady-state, topical
dose: 2.7 g
route of administration: Topical
experiment type: STEADY-STATE
co-administered:
OCTOCRYLENE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
3.7 g 1.3 times / day multiple, topical (median)
Recommended
Dose: 3.7 g, 1.3 times / day
Route: topical
Route: multiple
Dose: 3.7 g, 1.3 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 3.69 years (range: 0.64-48.15 years)
n = 79
Health Status: healthy
Age Group: 3.69 years (range: 0.64-48.15 years)
Sex: M+F
Population Size: 79
Sources:
https://www.fda.gov/media/71361/download
Other AEs: Dermatitis, Eczema...
Other AEs:
Dermatitis (2.5%)
Eczema (1.3%)
Sources:
https://www.fda.gov/media/71361/download
1.6 g 1.1 times / day multiple, topical (median)
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
n = 248
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Population Size: 248
Sources:
https://www.fda.gov/media/71361/download
Other AEs: Acne, Dermatitis...
Other AEs:
Acne (4.8%)
Dermatitis (2.8%)
Dry skin (1.2%)
Eczema (1.2%)
Erythema (1.2%)
Pruritus (2%)
Rosacea (0.4%)
Seborrhea (0.8%)
Skin discomfort (1.2%)
Sunburn (0.8%)
Conjunctivitis (0.8%)
Taste perversion (0.4%)
Sources:
https://www.fda.gov/media/71361/download
3.1 g 1.2 times / day multiple, topical (median)
Recommended
Dose: 3.1 g, 1.2 times / day
Route: topical
Route: multiple
Dose: 3.1 g, 1.2 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 6.69 years (range: 0.5-67.95 years)
n = 246
Health Status: healthy
Age Group: 6.69 years (range: 0.5-67.95 years)
Sex: M+F
Population Size: 246
Sources:
https://www.fda.gov/media/71361/download
Other AEs: Dermatitis, Eczema...
Other AEs:
Dermatitis (2.8%)
Eczema (0.4%)
Erythema (0.8%)
Skin discomfort (0.8%)
Sunburn (1.6%)
Conjunctivitis (0.4%)
Sources:
https://www.fda.gov/media/71361/download
AEs

AEs

AESignificanceDosePopulation
Eczema 1.3%
3.7 g 1.3 times / day multiple, topical (median)
Recommended
Dose: 3.7 g, 1.3 times / day
Route: topical
Route: multiple
Dose: 3.7 g, 1.3 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 3.69 years (range: 0.64-48.15 years)
n = 79
Health Status: healthy
Age Group: 3.69 years (range: 0.64-48.15 years)
Sex: M+F
Population Size: 79
Sources:
https://www.fda.gov/media/71361/download
Dermatitis 2.5%
3.7 g 1.3 times / day multiple, topical (median)
Recommended
Dose: 3.7 g, 1.3 times / day
Route: topical
Route: multiple
Dose: 3.7 g, 1.3 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 3.69 years (range: 0.64-48.15 years)
n = 79
Health Status: healthy
Age Group: 3.69 years (range: 0.64-48.15 years)
Sex: M+F
Population Size: 79
Sources:
https://www.fda.gov/media/71361/download
Rosacea 0.4%
1.6 g 1.1 times / day multiple, topical (median)
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
n = 248
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Population Size: 248
Sources:
https://www.fda.gov/media/71361/download
Taste perversion 0.4%
1.6 g 1.1 times / day multiple, topical (median)
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
n = 248
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Population Size: 248
Sources:
https://www.fda.gov/media/71361/download
Conjunctivitis 0.8%
1.6 g 1.1 times / day multiple, topical (median)
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
n = 248
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Population Size: 248
Sources:
https://www.fda.gov/media/71361/download
Seborrhea 0.8%
1.6 g 1.1 times / day multiple, topical (median)
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
n = 248
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Population Size: 248
Sources:
https://www.fda.gov/media/71361/download
Sunburn 0.8%
1.6 g 1.1 times / day multiple, topical (median)
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
n = 248
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Population Size: 248
Sources:
https://www.fda.gov/media/71361/download
Dry skin 1.2%
1.6 g 1.1 times / day multiple, topical (median)
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
n = 248
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Population Size: 248
Sources:
https://www.fda.gov/media/71361/download
Eczema 1.2%
1.6 g 1.1 times / day multiple, topical (median)
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
n = 248
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Population Size: 248
Sources:
https://www.fda.gov/media/71361/download
Erythema 1.2%
1.6 g 1.1 times / day multiple, topical (median)
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
n = 248
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Population Size: 248
Sources:
https://www.fda.gov/media/71361/download
Skin discomfort 1.2%
1.6 g 1.1 times / day multiple, topical (median)
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
n = 248
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Population Size: 248
Sources:
https://www.fda.gov/media/71361/download
Pruritus 2%
1.6 g 1.1 times / day multiple, topical (median)
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
n = 248
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Population Size: 248
Sources:
https://www.fda.gov/media/71361/download
Dermatitis 2.8%
1.6 g 1.1 times / day multiple, topical (median)
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
n = 248
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Population Size: 248
Sources:
https://www.fda.gov/media/71361/download
Acne 4.8%
1.6 g 1.1 times / day multiple, topical (median)
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
n = 248
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Population Size: 248
Sources:
https://www.fda.gov/media/71361/download
Conjunctivitis 0.4%
3.1 g 1.2 times / day multiple, topical (median)
Recommended
Dose: 3.1 g, 1.2 times / day
Route: topical
Route: multiple
Dose: 3.1 g, 1.2 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 6.69 years (range: 0.5-67.95 years)
n = 246
Health Status: healthy
Age Group: 6.69 years (range: 0.5-67.95 years)
Sex: M+F
Population Size: 246
Sources:
https://www.fda.gov/media/71361/download
Eczema 0.4%
3.1 g 1.2 times / day multiple, topical (median)
Recommended
Dose: 3.1 g, 1.2 times / day
Route: topical
Route: multiple
Dose: 3.1 g, 1.2 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 6.69 years (range: 0.5-67.95 years)
n = 246
Health Status: healthy
Age Group: 6.69 years (range: 0.5-67.95 years)
Sex: M+F
Population Size: 246
Sources:
https://www.fda.gov/media/71361/download
Erythema 0.8%
3.1 g 1.2 times / day multiple, topical (median)
Recommended
Dose: 3.1 g, 1.2 times / day
Route: topical
Route: multiple
Dose: 3.1 g, 1.2 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 6.69 years (range: 0.5-67.95 years)
n = 246
Health Status: healthy
Age Group: 6.69 years (range: 0.5-67.95 years)
Sex: M+F
Population Size: 246
Sources:
https://www.fda.gov/media/71361/download
Skin discomfort 0.8%
3.1 g 1.2 times / day multiple, topical (median)
Recommended
Dose: 3.1 g, 1.2 times / day
Route: topical
Route: multiple
Dose: 3.1 g, 1.2 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 6.69 years (range: 0.5-67.95 years)
n = 246
Health Status: healthy
Age Group: 6.69 years (range: 0.5-67.95 years)
Sex: M+F
Population Size: 246
Sources:
https://www.fda.gov/media/71361/download
Sunburn 1.6%
3.1 g 1.2 times / day multiple, topical (median)
Recommended
Dose: 3.1 g, 1.2 times / day
Route: topical
Route: multiple
Dose: 3.1 g, 1.2 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 6.69 years (range: 0.5-67.95 years)
n = 246
Health Status: healthy
Age Group: 6.69 years (range: 0.5-67.95 years)
Sex: M+F
Population Size: 246
Sources:
https://www.fda.gov/media/71361/download
Dermatitis 2.8%
3.1 g 1.2 times / day multiple, topical (median)
Recommended
Dose: 3.1 g, 1.2 times / day
Route: topical
Route: multiple
Dose: 3.1 g, 1.2 times / day
Co-administed with::
ecamsule
avobenzone
titanium dioxide
Sources:
https://www.fda.gov/media/71361/download
healthy, 6.69 years (range: 0.5-67.95 years)
n = 246
Health Status: healthy
Age Group: 6.69 years (range: 0.5-67.95 years)
Sex: M+F
Population Size: 246
Sources:
https://www.fda.gov/media/71361/download
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
P-gp
257
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
P-gp
1650
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY460449
https://www.001chemical.com/chem/6197-30-4
3B Scientific (Wuhan) Corp
3B3-012187
http://www.3bsc.com/index/pro_info.php?id=34690
AA Blocks
AA00IAVE
http://www.aablocks.com/goods/Goods/detail?id=AA00IAVE
AEchem Scientific Corp., USA
AE031997
http://www.aechemsc.com/info_products/AE031997.php
AK Scientific, Inc. (AKSCI)
J10375
http://www.aksci.com/item_detail.php?cat=J10375
Aaron Chemicals
AR00IBN6
http://www.aaronchem.com/6197-30-4
AbMole Bioscience
M5830
http://www.abmole.com/products/octocrylene.html
Acadechem
ACDS-026798
http://www.acadechemical.com/product/101497
Achemica
ACMC-209myd
http://www.achemica.com/prodinfo/?id=129801
Achemtek
0104-005960
http://www.achemtek.com/6197-30-4
Alfa Chemistry
ACM6197304-2
https://materials.alfachemic.com/product/2-ethylhexyl-2-cyano-3-3-cas-6197-30-4-337328.html
Alfa Chemistry
ACM6197304-1
https://materials.alfachemic.com/product/2-ethylhexyl-2-cyano-3-3-diphenylacrylate-cas-6197-30-4-337327.html
Alfa Chemistry
AP6197304-A
https://reagents.alfa-chemistry.com/product/octocrylene-cas-6197-30-4-14166.html
Alfa Chemistry
AP6197304-B
https://reagents.alfa-chemistry.com/product/octocrylene-cas-6197-30-4-14167.html
Alfa Chemistry
6197-30-4
https://www.alfa-chemistry.com/octocrilene-cas-6197-30-4-item-283669.htm
Ambeed
A201796
https://www.ambeed.com/products/6197-30-4.html
Ambinter
Amb17749058
http://www.ambinter.com/reference/17749058
Angene
AGN-PC-05W3YG
http://www.angenechemical.com/productshow/AGN-PC-05W3YG.html
Anward
ANW-34019
http://www.anward.com/pro_result/6993
Ark Pharm
AK-78708
http://www.arkpharminc.com/products/6197-30-4.html
Avantor Inc
700007-978
https://us.vwr.com/store/product/21573273/2-ethylhexyl-2-cyano-3-3-diphenylacrylate
Avantor Inc
700007-980
https://us.vwr.com/store/product/21573273/2-ethylhexyl-2-cyano-3-3-diphenylacrylate
BLD Pharm
BD1674
http://www.bldpharm.com/products/6197-30-4.html
BioChemPartner
BCP15293
http://www.biochempartner.com/6197-30-4-BCP15293
BioSynth
Q-201499
https://www.biosynth.com/en/products/life-science/other-biochemicals/products/Q-201499.html
Boerchem
BC225072
http://www.boerchem.com/?product_37872.html
CSNpharm
CSN22918
https://www.csnpharm.com/products/octocrylene.html
Capot Chemical
13147
http://www.capotchem.com/en/13147.htm
Capot Chemical
PubChem13147
http://www.capotchem.com/en/13147.htm
Chem Scene
CS-4296
http://www.chemscene.com/6197-30-4.html
ChemMol
30113285
http://www.chemmol.com/chemmol/30113285.html
ChemMol
44007278
http://www.chemmol.com/chemmol/44007278.html
ChemMol
49403764
http://www.chemmol.com/chemmol/49403764.html
ChemMol
99165642
http://www.chemmol.com/chemmol/99165642.html
Chemspace
CSSB00000041970
https://chem-space.com/CSSB00000041970
Clearsynth
CS-O-11009
https://www.clearsynth.com/en/CSO11009.html
Finetech
FT-0612234
http://www.finetechnology-ind.com/prod/detail/pub/6197-30-4.html
Hairui
HR124827
http://www.hairuichem.com/en/product/6197-30-4.html
LGC Standards
DRE-C15894510
https://www.lgcstandards.com/US/en/p/DRE-C15894510
LGC Standards
LGCFOR1552.00
https://www.lgcstandards.com/US/en/p/LGCFOR1552.00
LGC Standards
MM1552.00
https://www.lgcstandards.com/US/en/p/MM1552.00
Lab Network
LN00195470
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00195470
MedChem Express
HY-A0087
https://www.medchemexpress.com/Octocrylene.html
Molcore
MC460449
https://www.molcore.com/product/6197-30-4
MuseChem
I004338
https://www.musechem.com/product/I004338.html
Oakwood
217136
http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=98135&ExtHyperLink=1
Parchem
13018
http://www.parchem.com/chemical-supplier-distributor/Octocrylene-003018.aspx
Parchem
26772
http://www.parchem.com/chemical-supplier-distributor/Octocrylene-016772.aspx
Renno Tech
RL04347
http://www.rennotech.com/product_show.asp?id=4596
Sigma-Aldrich
415820_ALDRICH
https://www.sigmaaldrich.com/catalog/product/aldrich/415820?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
02343_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/02343?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
PHR1083_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/phr1083?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
1477411_USP
https://www.sigmaaldrich.com/catalog/product/usp/1477411?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech
S011141
http://www.sinfoobiotech.com/product/1014539
Smolecule
S573333
https://www.smolecule.com/products/s573333
TCI (Tokyo Chemical Industry)
C0968
http://www.tcichemicals.com/eshop/en/us/commodity/C0968/index.html
THE BioTek
bt-460979
https://www.thebiotek.com/product/others/bt-460979
VladaChem
VL269317-100G
https://www.vladachem.com/product.php?products=6197-30-4
Yuhao Chemical
XJ3062
http://www.chemyuhao.com/6197-30-4.html
abcr GmbH
AB140373
http://www.abcr.com/shop/en/AB140373
eNovation Chemicals
D275724
https://www.enovationchem.com/ProductDetails.asp?ProductID=D275724
iChemical
EBD3215
http://www.ichemical.com/chemicals/cas-6197-30-4
mcule
MCULE-9077867311
https://mcule.com/MCULE-9077867311/
PubMed

PubMed

TitleDatePubMed
Effects of active sunscreen ingredient combinations on the topical penetration of the herbicide 2,4-dichlorophenoxyacetic acid.
2003 Feb
Contact allergy to octocrylene.
2003 Jan
Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid.
2004 Mar 15
Development and validation of a non-aqueous reversed-phase high-performance liquid chromatographic method for the determination of four chemical UV filters in suncare formulations.
2004 Mar 26
Occurrence of UV filter compounds from sunscreens in surface waters: regional mass balance in two Swiss lakes.
2004 May
Determination of sixteen UV filters in suncare formulations by high-performance liquid chromatography.
2004 Sep 17
[Estrogenic activity of ultraviolet absorbers and the related compounds].
2005 Aug
Occurrence of some organic UV filters in wastewater, in surface waters, and in fish from Swiss Lakes.
2005 Feb 15
Sunscreen penetration of human skin and related keratinocyte toxicity after topical application.
2005 Jul-Aug
Assay of common sunscreen agents in suncare products by high-performance liquid chromatography on a cyanopropyl-bonded silica column.
2005 Jun 15
Sunscreens - which and what for?
2005 Nov-Dec
Contact allergy to octocrylene in sunscreen with recurrence from passive transfer of a cosmetic.
2005 Oct
Fate and removal of polycyclic musks, UV filters and biocides during wastewater treatment.
2006 Aug
Concentrations and specific loads of UV filters in sewage sludge originating from a monitoring network in Switzerland.
2006 Feb
Evaluation of the photostability of different UV filter combinations in a sunscreen.
2006 Jan 13
Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various Swiss rivers with inputs from wastewater treatment plants.
2006 Mar 1
Octocrylene: really non-allergenic?
2006 May
A validated method for the determination of traces of UV filters in fish using LC-MS/MS.
2006 Nov
Sunscreen enhancement of UV-induced reactive oxygen species in the skin.
2006 Oct 15
Occurrence and behavior of four of the most used sunscreen UV filters in a wastewater reclamation plant.
2007 Aug
Determination of UV filters and antimicrobial agents in environmental water samples.
2007 Feb
Study of the efficacy of 18 sun filters authorized in European Union tested in vitro.
2007 Jun
Photostability and efficacy studies of topical formulations containing UV-filters combination and vitamins A, C and E.
2007 Oct 1
Allergic and photoallergic contact dermatitis from ketoprofen: evaluation of cross-reactivities by a combination of photopatch testing and computerized conformational analysis.
2008
Development of a human in vivo method to study the effect of ultraviolet radiation and sunscreens in melanocytic nevi.
2008
Sunscreens cause coral bleaching by promoting viral infections.
2008 Apr
In vitro assessments of UVA protection by popular sunscreens available in the United States.
2008 Dec
Development of a method for the determination of UV filters in water samples using stir bar sorptive extraction and thermal desorption-gas chromatography-mass spectrometry.
2008 Feb 1
Multiclass determination of sunscreen chemicals in water samples by liquid chromatography-tandem mass spectrometry.
2008 Feb 15
Region-specific growth effects in the developing rat prostate following fetal exposure to estrogenic ultraviolet filters.
2008 Jul
Incorporation in lipid microparticles of the UVA filter, butyl methoxydibenzoylmethane combined with the UVB filter, octocrylene: effect on photostability.
2009
A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions.
2009 Feb
Determination of personal care products in sewage sludge by pressurized liquid extraction and ultra high performance liquid chromatography-tandem mass spectrometry.
2009 Jul 24
Determination of selected UV filters in indoor dust by matrix solid-phase dispersion and gas chromatography-tandem mass spectrometry.
2009 Jul 31
Non-porous membrane-assisted liquid-liquid extraction of UV filter compounds from water samples.
2009 Jun 12
Irradiation of skin and contrasting effects on absorption of hydrophilic and lipophilic compounds.
2009 Nov-Dec
Ultra-high-performance liquid chromatography-tandem mass spectrometry for determining the presence of eleven personal care products in surface and wastewaters.
2009 Oct 16
Octocrylene, an emerging photoallergen.
2010 Jul
A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen.
2010 Mar
Emergent and unusual allergens in cosmetics.
2010 May-Jun
Exposure patterns of UV filters, fragrances, parabens, phthalates, organochlor pesticides, PBDEs, and PCBs in human milk: correlation of UV filters with use of cosmetics.
2010 Nov
Simultaneous determination of UV filters and polycyclic musks in aqueous samples by solid-phase microextraction and gas chromatography-mass spectrometry.
2010 Oct 22
Patents

Patents

JP2000229829A
1
JP2008531514A
9
JP2010132647A
1
JP2011506326A
5
JP4740845B2
3
JP4852410B2
16
JPH05194171A
1
JPH07330561A
1

Sample Use Guides

In Vivo Use Guide
Apply 15 minutes before sun exposure.
Route of Administration: Topical
In Vitro Use Guide
The study was performed in vitro using a Franz type diffusion cell. Only one of the products contained octocrylene and the concentration was 70 g/L (~7%). The sunscreen product was applied to human skin (surface area = 1.13 -1.23 cm2). Following 8-hr topical applications of the products it was reported that no octocrylene was detected in the receptor fluid suggesting that penetration through the skin was minimal to non-existent.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:26:19 GMT 2023
Edited
by admin
on Fri Dec 15 15:26:19 GMT 2023
Record UNII
5A68WGF6WM
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OCTOCRYLENE
INCI   MI   ORANGE BOOK   USAN   USP   USP-RS  
INCI   USAN  
Official Name English
ANTHELIOS SX COMPONENT OCTOCRYLENE
Common Name English
OCTOCRYLENE [USP MONOGRAPH]
Common Name English
OCTOCRYLENE [USAN]
Common Name English
Octocrilene [WHO-DD]
Common Name English
2-CYANO-3,3-DIPHENYL-2-PROPENOIC ACID, 2-ETHYLHEXYL ESTER
Common Name English
OCTOCRYLENE COMPONENT OF CAPITAL SOLEIL
Common Name English
2-Ethylhexyl 2-cyano-3,3-diphenylacrylate
Systematic Name English
OCTOCRYLENE [INCI]
Common Name English
CAPITAL SOLEIL COMPONENT OCTOCRYLENE
Common Name English
NSC-760433
Code English
2-PROPENOIC ACID, 2-CYANO-3,3-DIPHENYL-, 2-ETHYLHEXYL ESTER
Common Name English
OCTOCRYLENE COMPONENT OF ANTHELIOS SX
Common Name English
octocrilene [INN]
Common Name English
OCTOCRYLENE [MI]
Common Name English
OCTOCRYLENE [ORANGE BOOK]
Common Name English
OCTOCRYLENE [USP-RS]
Common Name English
OCTOCRYLENE [USP IMPURITY]
Common Name English
OCTOCRILENE [MART.]
Common Name English
OCTOCRILENE
INN   MART.   WHO-DD  
INN  
Official Name English
Classification Tree Code System Code
Food Contact Sustance Notif, (FCN No.) FCN NO. 217
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
CFR 21 CFR 352.10
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
NCI_THESAURUS C851
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
CFR 21 CFR 352.20
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
Code System Code Type Description
ECHA (EC/EINECS)
228-250-8
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
RS_ITEM_NUM
1477411
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
DRUG CENTRAL
3395
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
MERCK INDEX
m8115
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY Merck Index
INN
4719
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
MESH
C088673
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
PUBCHEM
22571
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
NCI_THESAURUS
C84027
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
CAS
6197-30-4
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
WIKIPEDIA
OCTOCRYLENE
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
EVMPD
SUB09413MIG
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
NSC
760433
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
EPA CompTox
DTXSID9025299
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
SMS_ID
100000083846
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
DAILYMED
5A68WGF6WM
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
ChEMBL
CHEMBL1201147
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
RXCUI
77674
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY RxNorm
FDA UNII
5A68WGF6WM
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
DRUG BANK
DB09535
Created by admin on Fri Dec 15 15:26:19 GMT 2023 , Edited by admin on Fri Dec 15 15:26:19 GMT 2023
PRIMARY
Related Record Type Details
Structure of OCTOCRYLENE
ACTIVE MOIETY
NIH
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DISCLAIMER
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