Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H22N4O3 |
Molecular Weight | 318.3709 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCC1=C(O)C(=CC=C1OCCCCC2=NN=NN2)C(C)=O
InChI
InChIKey=MWYHLEQJTQJHSS-UHFFFAOYSA-N
InChI=1S/C16H22N4O3/c1-3-6-13-14(9-8-12(11(2)21)16(13)22)23-10-5-4-7-15-17-19-20-18-15/h8-9,22H,3-7,10H2,1-2H3,(H,17,18,19,20)
Molecular Formula | C16H22N4O3 |
Molecular Weight | 318.3709 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Originator
Sources: http://adisinsight.springer.com/drugs/800000075
Curator's Comment: # Eli Lilly
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Q9Y271 Gene ID: 10800.0 Gene Symbol: CYSLTR1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/3981452 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2554766 |
Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Mechanism of phosgene-induced lung toxicity: role of arachidonate mediators. | 1990 Nov |
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Endogenously formed leukotriene C4 activates LTC4 receptors in guinea pig tracheal strips. | 1991 Mar 26 |
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Anti-leukotriene effects of WY-50,295 tromethamine in isolated guinea pig pulmonary tissues. | 1993 Apr 6 |
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In vivo characterization of zymosan-induced mouse peritoneal inflammation. | 1994 Jun |
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Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate. | 1996 Jul |
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Pharmacology of leukotriene receptor antagonists. | 1998 Jun |
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Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma. | 2002 Jun |
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Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. | 2003 Apr |
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Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine. | 2003 Jan 10 |
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Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. | 2004 Oct |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2554766
600 mg twice daily for 6 weeks
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1706765
LY171883 functioned primarily as a leukotriene receptor antagonist with minimal pharmacological activity attributable to its ability to potentiate isoprenaline. Relaxation of carbachol-contracted guinea-pig trachea by isoprenaline was enhanced by the three agents in a dose-dependent manner. A two-fold enhancement of isoprenaline-induced smooth muscle relaxation was produced by 2.5 microM IBMX, 28 microM LY171883, or 140 microM theophylline. LY171883 totally inhibited the response and had significant LTE4 receptor antagonist activity even at 10-fold lower concentrations.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:16:18 GMT 2023
by
admin
on
Fri Dec 15 15:16:18 GMT 2023
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Record UNII |
59762X5CLS
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Record Status |
Validated (UNII)
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Record Version |
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C29712
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT | |||
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TARGET -> INHIBITOR |
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Related Record | Type | Details | ||
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ACTIVE MOIETY |