TOMELUKAST

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H22N4O3
Molecular Weight	318.3709
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC1=C(OCCCCC2=NN=NN2)C=CC(C(C)=O)=C1O

InChI

InChIKey=MWYHLEQJTQJHSS-UHFFFAOYSA-N

InChI=1S/C16H22N4O3/c1-3-6-13-14(9-8-12(11(2)21)16(13)22)23-10-5-4-7-15-17-19-20-18-15/h8-9,22H,3-7,10H2,1-2H3,(H,17,18,19,20)

HIDE SMILES / InChI

Molecular Formula	C16H22N4O3
Molecular Weight	318.3709
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18031150 | https://www.ncbi.nlm.nih.gov/pubmed/3981452

Tomelukast (previously known as LY171883), an orally active antagonist of the CysLT1 receptor (leukotriene D4), which was investigated to treat asthma, but this study was discontinued because of adverse gastrointestinal effect.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cysteinyl leukotriene receptor 1 18 Target ID: Q9Y271 Gene ID: 10800.0 Gene Symbol: CYSLTR1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/3981452	Antagonist 2849

Conditions

Condition	Modality	Targets	Highest Phase	Product
Asthma 244 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2554766	Primary		Withdrawn	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1).	2009-07	19398503
Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro.	2004-10	15491415
Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.	2004-04	14718577
Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13.	2003-04	12654629
Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine.	2003-01-10	12505531
Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines.	2002-08	12115725
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma.	2002-06	12065618
Pharmacology of leukotriene receptor antagonists	1998-06	9620942
Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate.	1996-07	8700121
In vivo characterization of zymosan-induced mouse peritoneal inflammation.	1994-06	8014878
Anti-leukotriene effects of WY-50,295 tromethamine in isolated guinea pig pulmonary tissues.	1993-04-06	8482329
Endogenously formed leukotriene C4 activates LTC4 receptors in guinea pig tracheal strips.	1991-03-26	1651863
Mechanism of phosgene-induced lung toxicity: role of arachidonate mediators.	1990-11	2125593

Patents

Sample Use Guides

In Vivo Use Guide

600 mg twice daily for 6 weeks

Route of Administration: Oral

In Vitro Use Guide

LY171883 functioned primarily as a leukotriene receptor antagonist with minimal pharmacological activity attributable to its ability to potentiate isoprenaline. Relaxation of carbachol-contracted guinea-pig trachea by isoprenaline was enhanced by the three agents in a dose-dependent manner. A two-fold enhancement of isoprenaline-induced smooth muscle relaxation was produced by 2.5 microM IBMX, 28 microM LY171883, or 140 microM theophylline. LY171883 totally inhibited the response and had significant LTE4 receptor antagonist activity even at 10-fold lower concentrations.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:52:19 GMT 2025` Edited by `admin` on `Mon Mar 31 17:52:19 GMT 2025`
Record UNII	59762X5CLS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LY-171833

Preferred Name

English

TOMELUKAST

Official Name

English

ETHANONE, 1-(2-HYDROXY-3-PROPYL-4-(4-(1H-TETRAZOL-5-YL)BUTOXY)PHENYL)-

Systematic Name

English

TOMELUKAST [MART.]

Common Name

English

LY-171883

Code

English

LY171883

Code

English

tomelukast [INN]

Common Name

English

TOMELUKAST [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29712