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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H22N2O2.CH4O3S
Molecular Weight 358.453
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DABELOTINE MESYLATE, (S)-

SMILES

CS(O)(=O)=O.CN1CCCC2=C1C(OC[C@@H]3CNCCO3)=CC=C2

InChI

InChIKey=RSEKRLGWBUABQM-ZOWNYOTGSA-N
InChI=1S/C15H22N2O2.CH4O3S/c1-17-8-3-5-12-4-2-6-14(15(12)17)19-11-13-10-16-7-9-18-13;1-5(2,3)4/h2,4,6,13,16H,3,5,7-11H2,1H3;1H3,(H,2,3,4)/t13-;/m0./s1

HIDE SMILES / InChI

Molecular Formula CH4O3S
Molecular Weight 96.106
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C15H22N2O2
Molecular Weight 262.3474
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Dabelotine is a cognitive-enhancing drug, developed by Servier. The drug has been shown to improve some aspects of cognitive processes, such as attention, curiosity, motivation, acquisition, and recall of memory. Dabelotine has also been shown to reduce the effect of an anticholinergic drug such as scopolamine. The drug increases the in vitro K+-induced norepinephrine release in rodent cerebral slices, and have no effect on noradrenergic and cholinergic receptor binding sites. Dabelotine was investigated in phase 2 clinical trials for the treatment of dementia, where it was demonstrated that 50-mg and 100-mg doses produced an improvement in reaction time and performance in memory tasks.

Approval Year

Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 11:13:04 GMT 2023
Edited
by admin
on Sat Dec 16 11:13:04 GMT 2023
Record UNII
596JG0W99X
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DABELOTINE MESYLATE, (S)-
Common Name English
QUINOLINE, 1,2,3,4-TETRAHYDRO-1-METHYL-8-((2S)-2-MORPHOLINYLMETHOXY)-, MONOMETHANESULFONATE, (S)-
Systematic Name English
(+)-(S)-S-12024
Code English
S-12024
Code English
Code System Code Type Description
FDA UNII
596JG0W99X
Created by admin on Sat Dec 16 11:13:04 GMT 2023 , Edited by admin on Sat Dec 16 11:13:04 GMT 2023
PRIMARY
PUBCHEM
132958
Created by admin on Sat Dec 16 11:13:04 GMT 2023 , Edited by admin on Sat Dec 16 11:13:04 GMT 2023
PRIMARY
EPA CompTox
DTXSID30934642
Created by admin on Sat Dec 16 11:13:04 GMT 2023 , Edited by admin on Sat Dec 16 11:13:04 GMT 2023
PRIMARY
CAS
152985-36-9
Created by admin on Sat Dec 16 11:13:04 GMT 2023 , Edited by admin on Sat Dec 16 11:13:04 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY