RILOPIROX

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H16ClNO4
Molecular Weight	357.788
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC(=O)N(O)C(COC2=CC=C(OC3=CC=C(Cl)C=C3)C=C2)=C1

InChI

InChIKey=UDYUIWXQUBNDHC-UHFFFAOYSA-N

InChI=1S/C19H16ClNO4/c1-13-10-15(21(23)19(22)11-13)12-24-16-6-8-18(9-7-16)25-17-4-2-14(20)3-5-17/h2-11,23H,12H2,1H3

HIDE SMILES / InChI

Molecular Formula	C19H16ClNO4
Molecular Weight	357.788
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2233892 | https://www.ncbi.nlm.nih.gov/pubmed/10394849 | https://www.ncbi.nlm.nih.gov/pubmed/11893219

Rilopirox (HOE 351) is a fungicidal antimycotic that was developed as an intravaginal antifungal with a long skin retention time and a strong killing effect on pathogenic yeasts. Its very low water solubility makes rilopirox a good candidate for an intravaginal antifungal. Potential applications may be in mucosal candida infections, tinea versicolor and seborrheic dermatitis. In addition, it has been suggested that rilopirox could be effective against oropharyngeal Candida infections, for example in AIDS patients. There is no information on current development of rilopirox.

Originator

Approval Year

PubMed

Title	Date	PubMed
[The in vitro properties of a new hydroxypyridone antimycotic rilopirox, with special reference to its anti-Candida activity].	1999-02	10221179
The hydroxypyridones: a class of antimycotics of its own.	1997-11	9476505

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:58:49 GMT 2025` Edited by `admin` on `Mon Mar 31 17:58:49 GMT 2025`
Record UNII	595T4D0KQ3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

rilopirox [INN]

Preferred Name

English

RILOPIROX

Official Name

English

Classification Tree Code System Code

NCI_THESAURUS

C514