PIFOXIME

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H20N2O3
Molecular Weight	276.3309
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of PIFOXIME

Structure Search

SMILES

CC(=NO)C1=CC=C(OCC(=O)N2CCCCC2)C=C1

InChI

InChIKey=XUDSQIDNHJMBBW-VBKFSLOCSA-N

InChI=1S/C15H20N2O3/c1-12(16-19)13-5-7-14(8-6-13)20-11-15(18)17-9-3-2-4-10-17/h5-8,19H,2-4,9-11H2,1H3/b16-12-

HIDE SMILES / InChI

Molecular Formula	C15H20N2O3
Molecular Weight	276.3309
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://books.google.ru/books?id=0vXTBwAAQBAJ&pg=PA980&lpg=PA980&dq=PIFOXIME retrieved from The Dictionary of Drugs: Chemical Data Chemical Data, Structures and Bibliographies Editors: Elks, J. (Ed.), p. 980
Curator's Comment: Description was created based on several sources, including http://www.theinfolist.com/php/SummaryGet.php?FindGo=withdrawn_drug https://static-content.springer.com/esm/art%3A10.1186%2Fs12916-016-0553-2/MediaObjects/12916_2016_553_MOESM3_ESM.pdf

Antiinflamatory agent, analgesic, antipyretic, COX inhibitor. Approved in France in 1975, withdrawn in 1976 because of the neuropsychiatric reactions

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Cyclooxygenase 89 Target ID: CHEMBL2094253 Sources: https://static-content.springer.com/esm/art%3A10.1186%2Fs12916-016-0553-2/MediaObjects/12916_2016_553_MOESM3_ESM.pdf	Inhibitor 8297

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 980, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ	Palliative		Approved 8429	Pixifenide Approved Use Antiinflamatory agent, analgesic Launch Date 1974

Patents

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:42:34 GMT 2023` Edited by `admin` on `Sat Dec 16 16:42:34 GMT 2023`
Record UNII	5947ECZ7WH
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PIFOXIME

Official Name

English

1-((P-ACETYLPHENOXY)ACETYL)PIPERIDINE P-OXIME

Common Name

English

pifoxime [INN]

Common Name

English

Code System Code Type Description

FDA UNII

5947ECZ7WH

Created by admin on Sat Dec 16 16:42:34 GMT 2023 , Edited by admin on Sat Dec 16 16:42:34 GMT 2023

PRIMARY

ChEMBL

CHEMBL1998966

Created by admin on Sat Dec 16 16:42:34 GMT 2023 , Edited by admin on Sat Dec 16 16:42:34 GMT 2023

PRIMARY

SMS_ID

100000081947

Created by admin on Sat Dec 16 16:42:34 GMT 2023 , Edited by admin on Sat Dec 16 16:42:34 GMT 2023

PRIMARY

PUBCHEM

35755

Created by admin on Sat Dec 16 16:42:34 GMT 2023 , Edited by admin on Sat Dec 16 16:42:34 GMT 2023

PRIMARY

EPA CompTox

DTXSID2048828

Created by admin on Sat Dec 16 16:42:34 GMT 2023 , Edited by admin on Sat Dec 16 16:42:34 GMT 2023

PRIMARY

NCI_THESAURUS

C166830

Created by admin on Sat Dec 16 16:42:34 GMT 2023 , Edited by admin on Sat Dec 16 16:42:34 GMT 2023

PRIMARY

CAS

31224-92-7

Created by admin on Sat Dec 16 16:42:34 GMT 2023 , Edited by admin on Sat Dec 16 16:42:34 GMT 2023

PRIMARY

EVMPD

SUB09831MIG

Created by admin on Sat Dec 16 16:42:34 GMT 2023 , Edited by admin on Sat Dec 16 16:42:34 GMT 2023

PRIMARY

INN

3949

Created by admin on Sat Dec 16 16:42:34 GMT 2023 , Edited by admin on Sat Dec 16 16:42:34 GMT 2023

PRIMARY

Related Record Type Details


					5947ECZ7WH

PIFOXIME

ACTIVE MOIETY