Bacitracin

US Approved OTC

First marketed in 1921

Description
Sources: http://femsle.oxfordjournals.org/content/femsle/320/1/33.full.pdf
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf

Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
C55-isoprenyl pyrophosphate 7 Target ID: CHEMBL2364036 Sources: http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC389626&blobtype=pdf	Binding Agent 1076

Conditions

Condition	Modality	Highest Phase	Product
Infection 8 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d827faa-bbbb-4d1d-b806-392b29290c81	Curative	Approved 8583	BACITRACIN Approved Use Uses first aid to help prevent infection in: •minor cuts •scrapes •burns Launch Date 1948
Skin diseases 10 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf	Curative	Approved 8583	CORTISPORIN Approved Use For the treatment of corticosteroid-responsice dermatoses with secondary infection. Launch Date 1957
Superficial infections of the external eye and its adnexa caused by susceptible bacteria 5 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/50417slr011_neosporin_lbl.pdf	Curative	Approved 8583	NEOSPORIN Approved Use NEOSPORIN Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis. Launch Date 1968

PubMed

Title	Date	PubMed
Bacitracin Inhibits the Migration of U87-MG Glioma Cells via Interferences of the Integrin Outside-in Signaling Pathway.	2016-03	26962415
Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.	2004-04	12972402
Thymulin evokes IL-6-C/EBPbeta regenerative repair and TNF-alpha silencing during endotoxin exposure in fetal lung explants.	2004-03	12639846
Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.	2003-12-05	14506276
Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process.	2003-11-14	12947092
Zinc modulates mRNA levels of cytokines.	2003-11	12812920
Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family.	2003-10-03	12885774
Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.	2003-10-03	12732622
Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.	2003-10-01	12839489
Zinc modulates PPARgamma signaling and activation of porcine endothelial cells.	2003-10	14519784
O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145.	2003-09-23	12974631
Purification of recombinant human apometallothionein-3 and reconstitution with zinc.	2003-09	12963354
The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice.	2003-08-29	12801924
Redox labile site in a Zn4 cluster of Cu4,Zn4-metallothionein-3.	2003-08-19	12911326
Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor.	2003-08-15	12915106
Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.	2003-08-01	12888280
Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts.	2003-08	12888634
Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1.	2003-07-11	12716893
Differential effects of zinc on functionally distinct human growth hormone mutations.	2003-07	12915731
In vitro effect of metal ions on the activity of two amphibian glyceraldehyde-3-phosphate dehydrogenases: potential metal binding sites.	2003-06	12798935
Zinc accumulation in N-methyl-N-nitrosourea-induced rat mammary tumors is accompanied by an altered expression of ZnT-1 and metallothionein.	2003-06	12773700
Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase.	2003-05-02	12595529
Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform.	2003-04	12714242
Effect of chromium on apolipoprotein A-I expression in HepG2 cells.	2003-04	12679171
Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays.	2003-04	12672911
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases.	2003-03	12572668
Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes.	2003-02-15	12566098
Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase.	2003-02-04	12549918
A novel class of ligand-gated ion channel is activated by Zn2+.	2003-01-10	12381728
p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice.	2003-01-01	12517797
Activation of the rainbow trout metallothionein-A promoter by silver and zinc.	2003-01	12524046
The permissive effect of zinc deficiency on uroguanylin and inducible nitric oxide synthase gene upregulation in rat intestine induced by interleukin 1alpha is rapidly reversed by zinc repletion.	2003-01	12514266
Pancreatic metallothionein-I may play a role in zinc homeostasis during maternal dietary zinc deficiency in mice.	2003-01	12514265
Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle.	2002-12-13	12354775
Isolation of GIF from porcine brain and studies of its zinc transfer kinetics with apo-carbonic anhydrase.	2002-12	12405537
Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.	2002-11	12429649
Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation.	2002-11	12421840
Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-kappaB activation.	2002-10	12389026
[Effect of zinc deficiency and zinc replenishment on HOX3.5 gene expression in mouse embryos].	2001-11	12561611
Detection by HPLC-ICP of metallothionein in serum of an epileptic child with valproate-associated hepatotoxicity.	1992-12	1304235
Differential dephosphorylation of the insulin receptor and its 160-kDa substrate (pp160) in rat adipocytes.	1992-07-15	1321133
In vitro sensitivity of Bacillus proteus and Pseudomonas aeruginosa to seven antibiotics; penicillin, streptomycin, bacitracin, polymyxin, aerosporin, aureomycin, and chloromycetin.	1950-02	15404235
Systemic bacitracin in the treatment of progressive bacterial synergistic gangrene.	1950-02	15402788
The Use of Bacitracin in Experimental Clostridium Welchii Infection in Guinea Pigs.	1949-10	17859460
IN VITRO STUDIES ON POSSIBLE SYNERGISTIC ACTION BETWEEN PENICILLIN AND BACITRACIN.	1949-09	16695753
The Results of the Systemic Administration of the Antibiotic, Bacitracin, in Surgical Infections: A Preliminary Report.	1948-10	17859227
A Note on the Susceptibility of Hemophilus influenzae Type B to Bacitracin.	1948-10	16561599
The relative antisyphilitic activity of penicillins F,G,K, and X and of bacitracin, based on the amounts required to abort early syphilic infections in rabbits.	1948-03	18902256
The Action of Bacitracin and Subtilin on Treponema pallidum in Vitro and in Vivo.	1948-03	16561465
Bacitracin: Methods of Production, Concentration, and Partial Purification, with a Summary of the Chemical Properties of Crude Bacitracin.	1948-02	16561454

Patents

Sample Use Guides

In Vivo Use Guide

400 units, topically

Route of Administration: Topical

In Vitro Use Guide

The MIC value was 32 mg/L for Staphylococcus aureus wild type strain after 48h incubation at 37°C.

Substance Class	Mixture Created by `admin` on `Wed Apr 02 09:38:17 GMT 2025` Edited by `admin` on `Wed Apr 02 09:38:17 GMT 2025`
Record UNII	58H6RWO52I
Record Status	`Validated (UNII)`
Record Version

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Classification Tree Code System Code

FDA ORPHAN DRUG

1284