Bacitracin

US Approved OTC

First marketed in 1921

Description
Sources: http://femsle.oxfordjournals.org/content/femsle/320/1/33.full.pdf
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf

Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
C55-isoprenyl pyrophosphate 7 Target ID: CHEMBL2364036 Sources: http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC389626&blobtype=pdf	Binding Agent 1064

Conditions

Condition	Modality	Highest Phase	Product
Infection 7 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d827faa-bbbb-4d1d-b806-392b29290c81	Curative	Approved 8429	BACITRACIN Approved Use Uses first aid to help prevent infection in: •minor cuts •scrapes •burns Launch Date 1948
Skin diseases 10 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf	Curative	Approved 8429	CORTISPORIN Approved Use For the treatment of corticosteroid-responsice dermatoses with secondary infection. Launch Date 1957
Superficial infections of the external eye and its adnexa caused by susceptible bacteria 5 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/50417slr011_neosporin_lbl.pdf	Curative	Approved 8429	NEOSPORIN Approved Use NEOSPORIN Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis. Launch Date 1968

PubMed

Title	Date	PubMed
The Action of Bacitracin and Subtilin on Treponema pallidum in Vitro and in Vivo.	1948 Mar	16561465
Systemic bacitracin in the treatment of progressive bacterial synergistic gangrene.	1950 Feb	15402788
Detection by HPLC-ICP of metallothionein in serum of an epileptic child with valproate-associated hepatotoxicity.	1992 Dec	1304235
Differential dephosphorylation of the insulin receptor and its 160-kDa substrate (pp160) in rat adipocytes.	1992 Jul 15	1321133
Intestinal damage induced by zinc deficiency is associated with enhanced CuZn superoxide dismutase activity in rats: effect of dexamethasone or thyroxine treatment.	1999 May	10381190
Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene.	1999 Sep 10	10473555
The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.	2000 Feb 15	10673434
Regulation of metallothionein gene expression by oxidative stress and metal ions.	2000 Jan 1	10605938
Therapeutic application of zinc in human immunodeficiency virus against opportunistic infections.	2000 May	10801955
Effect of the two conserved prolines of human growth inhibitory factor (metallothionein-3) on its biological activity and structure fluctuation: comparison with a mutant protein.	2000 Nov 28	11087412
cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changes.	2001 Dec	11739864
Nitric oxide induces metallothionein (MT) gene expression apparently by displacing zinc bound to MT.	2001 Feb 28	11311571
Cleavage of SNAP-25 by botulinum toxin type A requires receptor-mediated endocytosis, pH-dependent translocation, and zinc.	2001 Mar	11181932
p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis.	2001 May 15	11331359
Loss of vesicular zinc and appearance of perikaryal zinc after seizures induced by pilocarpine.	2001 May 25	11388441
Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities.	2001 Nov	11701772
Influence of dietary zinc deficiency during development on hepatic CYP2C11, CYP2C12, CYP3A2, CYP3A9, and CYP3A18 expression in postpubertal male rats.	2001 Nov 1	11705462
Modulation of intestinal gene expression by dietary zinc status: effectiveness of cDNA arrays for expression profiling of a single nutrient deficiency.	2001 Nov 20	11717422
Metallothionein is required for zinc-induced expression of the macrophage colony stimulating factor gene.	2002	12112025
Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle.	2002 Dec 13	12354775
Reduction of copper and metallothionein in toxic milk mice by tetrathiomolybdate, but not deferiprone.	2002 Jan 15	11803042
Partitioning of accumulated trace metals in the talitrid amphipod crustacean Orchestia gammarellus: a cautionary tale on the use of metallothionein-like proteins as biomarkers.	2002 Jun	11932003
Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.	2002 Nov	12429649
Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-kappaB activation.	2002 Oct	12389026
Effect of chromium on apolipoprotein A-I expression in HepG2 cells.	2003 Apr	12679171
The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice.	2003 Aug 29	12801924
Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase.	2003 Feb 4	12549918
Pancreatic metallothionein-I may play a role in zinc homeostasis during maternal dietary zinc deficiency in mice.	2003 Jan	12514265
In vitro effect of metal ions on the activity of two amphibian glyceraldehyde-3-phosphate dehydrogenases: potential metal binding sites.	2003 Jun	12798935
Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase.	2003 May 2	12595529
Zinc modulates PPARgamma signaling and activation of porcine endothelial cells.	2003 Oct	14519784
Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.	2003 Oct 3	12732622

Patents

Sample Use Guides

In Vivo Use Guide

400 units, topically

Route of Administration: Topical

In Vitro Use Guide

The MIC value was 32 mg/L for Staphylococcus aureus wild type strain after 48h incubation at 37°C.

Substance Class	Mixture Created by `admin` on `Sat Dec 16 17:50:15 GMT 2023` Edited by `admin` on `Sat Dec 16 17:50:15 GMT 2023`
Record UNII	58H6RWO52I
Record Status	`Validated (UNII)`
Record Version

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Classification Tree Code System Code

FDA ORPHAN DRUG

1284