CLOFENAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H7ClN2O4S2
Molecular Weight	270.714
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NS(=O)(=O)C1=CC(=C(Cl)C=C1)S(N)(=O)=O

InChI

InChIKey=NENBAISIHCWPKP-UHFFFAOYSA-N

InChI=1S/C6H7ClN2O4S2/c7-5-2-1-4(14(8,10)11)3-6(5)15(9,12)13/h1-3H,(H2,8,10,11)(H2,9,12,13)

HIDE SMILES / InChI

Molecular Formula	C6H7ClN2O4S2
Molecular Weight	270.714
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/uk/pdf/leaflet/725899.pdf
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/international/clofenamide.html and https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C77559

Clofenamide is a benzenedisulfonamide-based agent and carbonic anhydrase (CA) inhibitor with diuretic activity. Clofenamide inhibits CA, thereby preventing sodium, bicarbonate and thus water reabsorption in the proximal convoluted tubule resulting in diuresis.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Carbonic anhydrase 6 Target ID: CHEMBL2095180 Sources: http://www.genome.jp/dbget-bin/www_bget?D01822	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 567 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14041713	Primary		Approved 8429	Aponiere Approved Use Unknown

PubMed

Title	Date	PubMed
Electron-capture GLC assay of dichlorphenamide.	1979 Mar	423137
The influence of diuretics on the excretion and metabolism of doping agents. III. Etilamfetamine.	1986 Sep	3790195
Biopharmaceutical studies of thiazide diuretics. III. In vivo formation of 2-amino-4-chloro-m-benzenedisulfonamide as a metabolite of hydrochlorothiazide in a patient.	1987 Aug	3427729
Binding of 2-amino-4-chloro-m-benzenedisulfonamide as a metabolite of hydrochlorothiazide to erythrocytes.	1990 Oct	2076577
[X-ray structural analysis of kidney stones. Mechanism of action of pharmalith in nephrolithiasis].	1998 Nov-Dec	10079924

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:47:16 GMT 2023` Edited by `admin` on `Sat Dec 16 17:47:16 GMT 2023`
Record UNII	582ILN204B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLOFENAMIDE

Official Name

English

clofenamide [INN]

Common Name

English

CLOFENAMIDE [JAN]

Common Name

English

4-CHLORO-M-BENZENEDISULFONAMIDE

Common Name

English

Clofenamide [WHO-DD]

Common Name

English

MONOCHLORPHENAMIDE

Common Name

English

CLOFENAMIDE [MI]

Common Name

English

CHLORAMIDOBENZOL

Common Name

English

Classification Tree Code System Code

WHO-ATC

C03BA07