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Details

Stereochemistry ACHIRAL
Molecular Formula C6H7ClN2O4S2
Molecular Weight 270.714
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLOFENAMIDE

SMILES

NS(=O)(=O)C1=CC(=C(Cl)C=C1)S(N)(=O)=O

InChI

InChIKey=NENBAISIHCWPKP-UHFFFAOYSA-N
InChI=1S/C6H7ClN2O4S2/c7-5-2-1-4(14(8,10)11)3-6(5)15(9,12)13/h1-3H,(H2,8,10,11)(H2,9,12,13)

HIDE SMILES / InChI
Molecular Formula C6H7ClN2O4S2
Molecular Weight 270.714
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Clofenamide is a benzenedisulfonamide-based agent and carbonic anhydrase (CA) inhibitor with diuretic activity. Clofenamide inhibits CA, thereby preventing sodium, bicarbonate and thus water reabsorption in the proximal convoluted tubule resulting in diuresis.

Approval Year

Unknown
139,594

Targets

Primary TargetPharmacologyConditionPotency
Carbonic anhydrase
6
Inhibitor
8,297

Conditions

ConditionModalityTargetsHighest PhaseProduct
Hypertension
567
 Primary
Approved
8,429
Aponiere

PubMed

Patents

US2016038538
1
US4855289
1
US8362062
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
582ILN204B
Record Status Validated (UNII)
Record Version
NIH
NCATS
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