FLURITHROMYCIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C37H66FNO13
Molecular Weight	751.9172
Optical Activity	UNSPECIFIED
Defined Stereocenters	18 / 18
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)O[C@H]2[C@H](C)[C@@H](O[C@]3([H])O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@](C)(F)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]2C

InChI

InChIKey=XOEUHCONYHZURQ-HNUBZJOYSA-N

InChI=1S/C37H66FNO13/c1-14-24-37(10,46)29(42)21(5)28(41)34(7,38)17-35(8,45)31(52-33-26(40)23(39(11)12)15-18(2)48-33)19(3)27(20(4)32(44)50-24)51-25-16-36(9,47-13)30(43)22(6)49-25/h18-27,29-31,33,40,42-43,45-46H,14-17H2,1-13H3/t18-,19+,20-,21+,22+,23+,24-,25+,26-,27+,29-,30+,31-,33+,34+,35-,36-,37-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C37H66FNO13
Molecular Weight	751.9172
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	18 / 18
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67045925 | https://www.ncbi.nlm.nih.gov/pubmed/3487389 | https://www.ncbi.nlm.nih.gov/pubmed/1452490

FLURITHROMYCIN, an erythromycin fluorine derivative, was isolated from the fermentation broth of Streptomyces erythraeus ATCC 31772. It is used as an antibacterial drug. The spectrum of activity of FLURITHROMYCIN is almost identical to that of erythromycin but it is more stable to acid.

Approval Year

PubMed

Title	Date	PubMed
Antimicrobial activity and postantibiotic effect of flurithromycin against Helicobacter pylori strains.	2001 Feb	11165121
Antibacterial activity and post-antibiotic effect of flurithromycin compared with other macrolides and penicillins against periodontal pathogens.	2001 Jun	11450882
Inhibition of human neutrophil elastase by erythromycin and flurythromycin, two macrolide antibiotics.	2001 Oct	11694455
Comparison of systemic flurithromycin therapy and clinical procedures in the treatment of periodontal diseases.	2004 Apr	15216949
Fluroquinolone resistance in typhoidal Salmonella and its detection by nalidixic acid disc diffusion.	2004 Jun	15366793
Structure-activity relationships for three macrolide antibiotics in Haemophilus influenzae.	2004 Oct	15386112

Patents

Sample Use Guides

In Vitro Use Guide

Flurithromycin in vitro antibacterial activity was determined on recent clinical isolates of respiratory pathogens. The range of MIC for Streptococcus pneumoniae and Streptococcus beta-haemolyticus group A is from 0.0015 to 0.006 microgram/ml, for Haemophilus influenzae from 0.012 to 0.4 microgram/ml, for Staphylococcus aureus from 0.1 to 3.1 micrograms/ml.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:46:59 GMT 2023` Edited by `admin` on `Fri Dec 15 15:46:59 GMT 2023`
Record UNII	56C9DTE69V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLURITHROMYCIN

Official Name

English

FLURITHROMYCIN [MI]

Common Name

English

flurithromycin [INN]

Common Name

English

Flurithromycin [WHO-DD]

Common Name

English

(8S)-8-FLUOROERYTHROMYCIN

Common Name

English

Classification Tree Code System Code

WHO-ATC

J01FA14