Details
Stereochemistry | ACHIRAL |
Molecular Formula | C25H22N2O2 |
Molecular Weight | 382.4544 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CC=C(C=C1C2CCCC2)C3=CNC4=NC=C(C=C34)C5=CC=CC=C5
InChI
InChIKey=WVSBGSNVCDAMCF-UHFFFAOYSA-N
InChI=1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)
Molecular Formula | C25H22N2O2 |
Molecular Weight | 382.4544 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/18794135
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18794135
GSK650394 was synthesized by the CVU Medicinal Chemistry Department at GlaxoSmithKline as an inhibitor of serum- and glucocorticoid-regulated kinases, SGK1 and SGK2. It was shown, that GSK650394 possessed antiproliferative properties against the human prostate carcinoma cell line LNCaP.
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18794135
Curator's Comment: # CVU Medicinal Chemistry Department at GlaxoSmithKline
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: O00141|||Q5TCN4 Gene ID: 6446.0 Gene Symbol: SGK1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/18794135 |
62.0 nM [IC50] | ||
Target ID: Q9HBY8 Gene ID: 10110.0 Gene Symbol: SGK2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/18794135 |
103.0 nM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18794135
The inhibitory effects of GSK650394 on SGK1 activity were evaluated using cell-based assays. Importantly, GSK650394 is relatively nontoxic, with LC50 values of 41 μmol/L in M-1 cells (68 times its activity IC50) and LC50 >100 μmol/L in HeLa cells in XTT assays, which measure mitochondrial enzymatic activity. GSK650394 was evaluated for its effects on this well-documented SGK1-mediated biological activity, which was measured using an aldosterone-stimulated SCC cellular assay. GSK650394 inhibited SGK1-mediated epithelial transport with an IC50 of 0.6 μmol/L in the SCC assay.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:49:13 GMT 2023
by
admin
on
Sat Dec 16 09:49:13 GMT 2023
|
Record UNII |
56887611DJ
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
25022668
Created by
admin on Sat Dec 16 09:49:13 GMT 2023 , Edited by admin on Sat Dec 16 09:49:13 GMT 2023
|
PRIMARY | |||
|
DTXSID60237532
Created by
admin on Sat Dec 16 09:49:13 GMT 2023 , Edited by admin on Sat Dec 16 09:49:13 GMT 2023
|
PRIMARY | |||
|
56887611DJ
Created by
admin on Sat Dec 16 09:49:13 GMT 2023 , Edited by admin on Sat Dec 16 09:49:13 GMT 2023
|
PRIMARY | |||
|
890842-28-1
Created by
admin on Sat Dec 16 09:49:13 GMT 2023 , Edited by admin on Sat Dec 16 09:49:13 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |