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Details

Stereochemistry ABSOLUTE
Molecular Formula C62H88N13O14P.CN.Co
Molecular Weight 1356.3658
Optical Activity UNSPECIFIED
Defined Stereocenters 13 / 14
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CYANOCOBALAMIN CO-60

SMILES

[60Co+3].[C-]#N.C[C@H](CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)C2[N-]C1=C(C)C3=NC(=CC4=NC(=C(C)C5=N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O)OP([O-])(=O)O[C@@H]6[C@@H](CO)O[C@@H]([C@@H]6O)N7C=NC8=C7C=C(C)C(C)=C8

InChI

InChIKey=FDJOLVPMNUYSCM-BYCRCCONSA-L
InChI=1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;-1;+3/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56?,57+,59-,60+,61+,62+;;/m1../s1/i;;1+1

HIDE SMILES / InChI
Molecular Formula C62H87N13O14P
Molecular Weight 1269.4066
Charge -3
Count
Stereochemistry EPIMERIC
Additional Stereochemistry No
Defined Stereocenters 13 / 14
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula CHN
Molecular Weight 27.0253
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Co
Molecular Weight 59.933822196
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Cyanocobalamin Co-60 is an analog of Vitamin B12 labeled with Co60. Cyanocobalamin Co-60 was used for the diagnosis of pernicious anemia, but now it is withdrawn from the market in the US by unknown reasons.

Approval Year

1961
146
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Approved
8583
RUBRATOPE-60

Approved Use

Unknown

Launch Date

1971
PubMed

PubMed

TitleDatePubMed
[ALTERATIONS OF VITAMIN B 12 DUE TO THE EFFECT OF CO-60 GAMMA RADIATIONS].
1965-01-01
[Co 60-vitamin B 12-binding glycoproteins. I. Enrichment and characterization of Co 60-cyanocobalamine-binding glycoproteins from urine of leukemic and normal subjects].
1964-10-30
[EFFECTS EXERCISED BY DEPRIVATION OF PROTEINS OR CERTAIN ESSENTIAL AMINO ACIDS ON THE METABOLISM OF CO-60-LABELED VITAMIN B-12 IN THE MALE RAT].
1963
The uptake of cyanocobalamin-Co 60 by kidney and liver slices of normal and starved rabbits.
1961-12
Vitamin B12Co-60 readily passes the placenta into fetal organs and nursing provides B12 from mother to pup. A record of its distribution.
1960-09-01
Effect of different intrinsic factor preparations on Co 60 vit. B12 uptake in rat liver slices.
1958-08-01
Vitamin B12Co60 distribution in dog tissues during many months; red cell stroma with labeled B12 in hemolytic anemia.
1958-07-01

Sample Use Guides

In Vivo Use Guide
100-200 ug in 2 days (anemia associated with Vitamin B12), 400-500 micrograms in the first 7 days daily, then 1 time every 5-7 days (in anemia with symptoms of funicular myelosis and megalocytic anemia with diseases of the nervous system).
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:55:57 GMT 2025
Edited
by admin
on Mon Mar 31 17:55:57 GMT 2025
Record UNII
562RS6MC22
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYANOCOBALAMIN (60CO)
INN  
INN  
Preferred Name English
CYANOCOBALAMIN CO-60
ORANGE BOOK  
Common Name English
cyanocobalamin (??Co) [INN]
Common Name English
RACOBALAMIN-60
Code English
COBALT (60CO) CYANOCOBALAMIN
Common Name English
CYANOCOBALAMIN CO 60 [USAN]
Common Name English
RUBRATOPE-60 KIT COMPONENT CYANOCOBALAMIN CO-60
Common Name English
RUBRATOPE-60
Brand Name English
CYANOCOBALAMIN CO-60 [ORANGE BOOK]
Common Name English
CYANOCOBALAMIN (60 CO)
Common Name English
CYANOCOBALAMIN, CO-60
Common Name English
RADIOACTIVE 60CO VITAMIN B12 [MI]
Common Name English
CYANOCOBALAMIN CO 60
USAN  
USAN  
Official Name English
VITAMIN B12, CO-60
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C2124
Created by admin on Mon Mar 31 17:55:57 GMT 2025 , Edited by admin on Mon Mar 31 17:55:57 GMT 2025
Code System Code Type Description
CAS
13422-53-2
Created by admin on Mon Mar 31 17:55:57 GMT 2025 , Edited by admin on Mon Mar 31 17:55:57 GMT 2025
PRIMARY
SMS_ID
100000093001
Created by admin on Mon Mar 31 17:55:57 GMT 2025 , Edited by admin on Mon Mar 31 17:55:57 GMT 2025
PRIMARY
PUBCHEM
123133494
Created by admin on Mon Mar 31 17:55:57 GMT 2025 , Edited by admin on Mon Mar 31 17:55:57 GMT 2025
PRIMARY
NCI_THESAURUS
C76049
Created by admin on Mon Mar 31 17:55:57 GMT 2025 , Edited by admin on Mon Mar 31 17:55:57 GMT 2025
PRIMARY
EVMPD
SUB06840MIG
Created by admin on Mon Mar 31 17:55:57 GMT 2025 , Edited by admin on Mon Mar 31 17:55:57 GMT 2025
PRIMARY
MERCK INDEX
m11483
Created by admin on Mon Mar 31 17:55:57 GMT 2025 , Edited by admin on Mon Mar 31 17:55:57 GMT 2025
PRIMARY Merck Index
ChEMBL
CHEMBL2110563
Created by admin on Mon Mar 31 17:55:57 GMT 2025 , Edited by admin on Mon Mar 31 17:55:57 GMT 2025
PRIMARY
INN
2214
Created by admin on Mon Mar 31 17:55:57 GMT 2025 , Edited by admin on Mon Mar 31 17:55:57 GMT 2025
PRIMARY
FDA UNII
562RS6MC22
Created by admin on Mon Mar 31 17:55:57 GMT 2025 , Edited by admin on Mon Mar 31 17:55:57 GMT 2025
PRIMARY
Related Record Type Details
Structure of CYANOCOBALAMIN CO-60
ACTIVE MOIETY
NIH
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