U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Tertomotide (also known as GV1001) is a synthetic telomerase-specific peptide vaccine patented by Norsk Hydro Asa for the cancer treatment. The agent was initially developed as a cancer vaccine, for example, against pancreatic and prostate cancer. Telomerase, a reverse transcriptase normally repressed in healthy cells, is overexpressed in most cancer cells and plays a key role in cellular proliferation. Vaccination with Tertomotide may activate the immune system to mount a cytotoxic T-lymphocyte response against telomerase-expressing cells. Subsequently, in vivo studies have demonstrated the efficacy of Tertomotide in alleviating benign prostatic hyperplasia (BPH) symptoms by reducing the size of the prostate gland. The mechanism of action of Tertomotide has been proposed to be through its dual activity as a GnRH inhibitor and 5a-reductase inhibitor. The GnRH antagonist activity has been established by co-immunoprecipitation assay, demonstrating an interaction between Tertomotide and the GnRH receptor, which was abolished by pre-treatment with anti-GnRH receptor antibody.

Approval Year

PubMed

PubMed

TitleDatePubMed
A randomised, placebo-controlled, multicentre, Phase 2 clinical trial to evaluate the efficacy and safety of GV1001 in patients with benign prostatic hyperplasia.
2018 Aug
Patents

Patents

Sample Use Guides

0.56 mg GV1001 every 2 weeks
Route of Administration: Other
Substance Class Protein
Created
by admin
on Fri Dec 15 16:25:52 GMT 2023
Edited
by admin
on Fri Dec 15 16:25:52 GMT 2023
Protein Type PEPTIDE
Protein Sub Type T-CELL ANTIGEN
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
55R7RG342O
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TERTOMOTIDE
INN   WHO-DD  
INN  
Official Name English
GV1001
Code English
GV-1001
Code English
Tertomotide [WHO-DD]
Common Name English
tertomotide [INN]
Common Name English
HUMAN TELOMERASE REVERSE TRANSCRIPTASE PEPTIDE (AMINO ACID 611-626)
Common Name English
HUMAN TELOMERASE REVERSE TRANSCRIPTASE (EC 2.7.7.49)-(611-626)-PEPTIDE (TELOMERASE CATALYTIC SUBUNIT FRAGMENT)
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1663
Created by admin on Fri Dec 15 16:25:52 GMT 2023 , Edited by admin on Fri Dec 15 16:25:52 GMT 2023
NCI_THESAURUS C1752
Created by admin on Fri Dec 15 16:25:52 GMT 2023 , Edited by admin on Fri Dec 15 16:25:52 GMT 2023
Code System Code Type Description
INN
8929
Created by admin on Fri Dec 15 16:25:52 GMT 2023 , Edited by admin on Fri Dec 15 16:25:52 GMT 2023
PRIMARY
FDA UNII
55R7RG342O
Created by admin on Fri Dec 15 16:25:52 GMT 2023 , Edited by admin on Fri Dec 15 16:25:52 GMT 2023
PRIMARY
NCI_THESAURUS
C62756
Created by admin on Fri Dec 15 16:25:52 GMT 2023 , Edited by admin on Fri Dec 15 16:25:52 GMT 2023
PRIMARY
CAS
915019-08-8
Created by admin on Fri Dec 15 16:25:52 GMT 2023 , Edited by admin on Fri Dec 15 16:25:52 GMT 2023
PRIMARY
ChEMBL
CHEMBL2108308
Created by admin on Fri Dec 15 16:25:52 GMT 2023 , Edited by admin on Fri Dec 15 16:25:52 GMT 2023
PRIMARY
PUBCHEM
56843375
Created by admin on Fri Dec 15 16:25:52 GMT 2023 , Edited by admin on Fri Dec 15 16:25:52 GMT 2023
PRIMARY
DRUG BANK
DB12747
Created by admin on Fri Dec 15 16:25:52 GMT 2023 , Edited by admin on Fri Dec 15 16:25:52 GMT 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
TARGET->VACCINE ANTIGEN
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL