Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C32H34ClN7O2 |
| Molecular Weight | 584.111 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CCN(CC2=NC3=C(C=C(CN(CC#C)C4=CC=C(C=C4)C(=O)NCC5=CC=CN=C5)C(Cl)=C3)C(=O)N2C)CC1
InChI
InChIKey=LWTCFUSGPRGUBX-UHFFFAOYSA-N
InChI=1S/C32H34ClN7O2/c1-4-12-40(26-9-7-24(8-10-26)31(41)35-20-23-6-5-11-34-19-23)21-25-17-27-29(18-28(25)33)36-30(38(3)32(27)42)22-39-15-13-37(2)14-16-39/h1,5-11,17-19H,12-16,20-22H2,2-3H3,(H,35,41)
| Molecular Formula | C32H34ClN7O2 |
| Molecular Weight | 584.111 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/12166942|
DOI: http://dx.doi.org/10.1016/S0959-8049(02)80688-8
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/12166942|
DOI: http://dx.doi.org/10.1016/S0959-8049(02)80688-8
CB 300919 is a water-soluble analogue of CB30865. Preclinical data revealed that CB 300919 was a potential therapy for ovarian cancer, what was shown for tumor xenograft mice. CB 300919 is an inhibitor of Nicotinamide phosphoribosyltransferase.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent. | 2002 Aug 15 |
|
| Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt). | 2010 Dec 23 |
|
| Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound. | 2010 Jun 25 |
Patents
| Substance Class |
Chemical
Created
by
admin
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Edited
Sat Dec 16 11:08:24 GMT 2023
by
admin
on
Sat Dec 16 11:08:24 GMT 2023
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| Record UNII |
55I8ETE76Y
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| Record Status |
Validated (UNII)
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289715-28-2
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