Resugosbart

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 16:07:10 GMT 2023` Edited by `admin` on `Sat Dec 16 16:07:10 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	54YJA5WXB9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Resugosbart

Official Name

English

Immunoglobulin G4 [225-proline], anti-(human sclerostin) (human-Mus musculus monoclonal HR3012221 γ4-chain), disulfide with human-Mus musculus monoclonal HR3012221 κ-chain, dimer

Common Name

English

SHR-1222

Code

English

resugosbart [INN]

Common Name

English

SHR-1222 (HUMANIZED MONOCLONAL ANTIBODY TARGETED TO SOLUBLE SCLEROSTIN)

Common Name

English

AB-5 (HUMANIZED MONOCLONAL ANTIBODY TARGETED TO SOLUBLE SCLEROSTIN)

Common Name

English

gamma4 heavy chain (1-444) [VH (Homo sapiens IGHV1-18*01 (79,6%) -(IGHD)-IGHJ4*01 (93,3%), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117)-Homo sapiens IGHG4*01, IGHG4v5 h P10, nG4m(a) CH2 L92 (CH1 (118-215), hinge 1-12 S10>P (225) (216-227), CH2 L92 (30

Common Name

English

immunoglobulin G4-kappa, anti-[Homo sapiens SOST (sclerostin)], monoclonal antibody

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C190336

Created by admin on Sat Dec 16 16:07:10 GMT 2023 , Edited by admin on Sat Dec 16 16:07:10 GMT 2023

PRIMARY

INN

12244

Created by admin on Sat Dec 16 16:07:10 GMT 2023 , Edited by admin on Sat Dec 16 16:07:10 GMT 2023

PRIMARY

FDA UNII

54YJA5WXB9

Created by admin on Sat Dec 16 16:07:10 GMT 2023 , Edited by admin on Sat Dec 16 16:07:10 GMT 2023

PRIMARY

CAS

2647412-09-5

Created by admin on Sat Dec 16 16:07:10 GMT 2023 , Edited by admin on Sat Dec 16 16:07:10 GMT 2023

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_131	2_144
2_200	4_214
2_258	2_318
1_131	1_144
2_364	2_422
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_200	3_214
1_223	2_223
1_226	2_226
1_258	1_318
1_364	1_422

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_294
N	2_294

Related Record Type Details


					3G0YT654PE

SCLEROSTIN

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					54YJA5WXB9

Resugosbart

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL