PROFLAZEPAM

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H16ClFN2O3
Molecular Weight	362.783
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCC(O)CN1C2=CC=C(Cl)C=C2C(=NCC1=O)C3=CC=CC=C3F

InChI

InChIKey=RCDQRWWSKKYAJG-UHFFFAOYSA-N

InChI=1S/C18H16ClFN2O3/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)21-8-17(25)22(16)9-12(24)10-23/h1-7,12,23-24H,8-10H2

HIDE SMILES / InChI

Molecular Formula	C18H16ClFN2O3
Molecular Weight	362.783
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6686445 | https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=19740411&CC=DE&NR=2347455A1&KC=A1

Proflazepam is benzodiazepine derivative patented by Hoffmann-La Roche, F., und Co., A.-G. as anticonvulsant and muscle relaxant. In preclinical studies, Proflazepam shows activity in pentetrazole test and in the rotating rod test.

Originator

Approval Year

PubMed

Title	Date	PubMed
5-Phenyl-1,3-dihydro-1,4-benzodiazepin-2-ones. Experimental verification of substituent constants.	1983	6686445

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:46:02 GMT 2025` Edited by `admin` on `Mon Mar 31 18:46:02 GMT 2025`
Record UNII	545MN0F125
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

(±)-2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(2,3-DIHYDROXYPROPYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-

Preferred Name

English

PROFLAZEPAM

Official Name

English

proflazepam [INN]

Common Name

English

2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(2,3-DIHYDROXYPROPYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1012