U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C22H23FN6O3
Molecular Weight 438.4548
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RADEZOLID

SMILES

CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(F)=C(C=C2)C3=CC=C(CNCC4=CN=NN4)C=C3

InChI

InChIKey=BTTNOGHPGJANSW-IBGZPJMESA-N
InChI=1S/C22H23FN6O3/c1-14(30)25-12-19-13-29(22(31)32-19)18-6-7-20(21(23)8-18)16-4-2-15(3-5-16)9-24-10-17-11-26-28-27-17/h2-8,11,19,24H,9-10,12-13H2,1H3,(H,25,30)(H,26,27,28)/t19-/m0/s1

HIDE SMILES / InChI

Molecular Formula C22H23FN6O3
Molecular Weight 438.4548
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Radezolid (RX-1741) is a novel oxazolidinone antibiotic agent and is the first biaryloxazolidinone in clinical development. It is being developed by Rib-X Pharmaceuticals, Inc. for the treatment of serious multi-drug–resistant infections. Radezolid has completed two phase-II clinical trialsfor the treatment of community-acquired pneumonia; uncomplicated skin and skin structure infections. The mechanism of action for this drug seems to be an inhibition of 50S ribosomal subunit.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Unknown

Approved Use

Unknown
Curative
Unknown

Approved Use

Unknown
Curative
Unknown

Approved Use

Unknown
Curative
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

300 mg/day, orally for 7-10 days
Route of Administration: Oral
It was studied the mechanisms involved in radezolid accumulation in cells, using THP-1 macrophages as a model. Data were obtained after 2 h of incubation with 50 mg/liter radezolid. When cells were incubated at 4°C, the apparent cellular concentrations of radezolid decreased to about 35 to 40% of their control values. In parallel experiments, we observed that radezolid's accumulation was not modified by either ATP depletion or efflux pump inhibitors.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:14:34 GMT 2023
Edited
by admin
on Fri Dec 15 16:14:34 GMT 2023
Record UNII
53PC6LO35W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RADEZOLID
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
Radezolid [WHO-DD]
Common Name English
RX-013
Code English
RX-1741
Code English
RX-103
Code English
radezolid [INN]
Common Name English
AND RX-01_667
Code English
RADEZOLID [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C258
Created by admin on Fri Dec 15 16:14:34 GMT 2023 , Edited by admin on Fri Dec 15 16:14:34 GMT 2023
Code System Code Type Description
DRUG BANK
DB12339
Created by admin on Fri Dec 15 16:14:34 GMT 2023 , Edited by admin on Fri Dec 15 16:14:34 GMT 2023
PRIMARY
USAN
TT-99
Created by admin on Fri Dec 15 16:14:34 GMT 2023 , Edited by admin on Fri Dec 15 16:14:34 GMT 2023
PRIMARY
PUBCHEM
11224409
Created by admin on Fri Dec 15 16:14:34 GMT 2023 , Edited by admin on Fri Dec 15 16:14:34 GMT 2023
PRIMARY
FDA UNII
53PC6LO35W
Created by admin on Fri Dec 15 16:14:34 GMT 2023 , Edited by admin on Fri Dec 15 16:14:34 GMT 2023
PRIMARY
CAS
869884-78-6
Created by admin on Fri Dec 15 16:14:34 GMT 2023 , Edited by admin on Fri Dec 15 16:14:34 GMT 2023
PRIMARY
ChEMBL
CHEMBL455461
Created by admin on Fri Dec 15 16:14:34 GMT 2023 , Edited by admin on Fri Dec 15 16:14:34 GMT 2023
PRIMARY
EPA CompTox
DTXSID301007238
Created by admin on Fri Dec 15 16:14:34 GMT 2023 , Edited by admin on Fri Dec 15 16:14:34 GMT 2023
PRIMARY
INN
8999
Created by admin on Fri Dec 15 16:14:34 GMT 2023 , Edited by admin on Fri Dec 15 16:14:34 GMT 2023
PRIMARY
SMS_ID
300000034413
Created by admin on Fri Dec 15 16:14:34 GMT 2023 , Edited by admin on Fri Dec 15 16:14:34 GMT 2023
PRIMARY
NCI_THESAURUS
C81442
Created by admin on Fri Dec 15 16:14:34 GMT 2023 , Edited by admin on Fri Dec 15 16:14:34 GMT 2023
PRIMARY
MESH
C552047
Created by admin on Fri Dec 15 16:14:34 GMT 2023 , Edited by admin on Fri Dec 15 16:14:34 GMT 2023
PRIMARY
WIKIPEDIA
Radezolid
Created by admin on Fri Dec 15 16:14:34 GMT 2023 , Edited by admin on Fri Dec 15 16:14:34 GMT 2023
PRIMARY
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