NEOCINCHOPHEN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H17NO2
Molecular Weight	291.3438
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=C2C=C(C)C=CC2=NC(=C1)C3=CC=CC=C3

InChI

InChIKey=BUDBHJPMAKXMLD-UHFFFAOYSA-N

InChI=1S/C19H17NO2/c1-3-22-19(21)16-12-18(14-7-5-4-6-8-14)20-17-10-9-13(2)11-15(16)17/h4-12H,3H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C19H17NO2
Molecular Weight	291.3438
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://jamanetwork.com/journals/jama/article-abstract/227638 | https://books.google.ru/books?id=0vXTBwAAQBAJ&pg=PA810&lpg=PA810&dq=NEOCINCHOPHEN retrieved from The Dictionary of Drugs: Chemical Data. Chemical Data, Structures and Bibliographies. Editors: Elks, J. (Ed.), p. 810 | https://pdfs.semanticscholar.org/3500/592218bcac88dd4ba174e1698e720a3b3191.pdf

Neocinchophen is an analgesic and uricosuric. Cinchophen and neocinchophen (introduced by Chemische Fabrik auf Aktien as Atophan and Novatophan) were being advertised as superior substitutes for salicylates in the treatment of rheumatic fever. Chemically, cinchophen is phenylcinchoninic acid, and neocinchophen is the ethyl ester of its methyl derivative.

Originator

Approval Year

Sample Use Guides

In Vivo Use Guide

Rheumatic fever: Neocinchophen was administered in tablet form, 1 g of the drug being used every hour until definite symptoms of drug action were manifested. The three patients with rheumatic fever that were treated with neocinchophen obtained complete relief from subjective and objective symptoms of the disease after doses of 11, 14 and 16 g. One patient received with impunity 15 g additional to the 11 g, which gave him complete relief.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:18:17 GMT 2025` Edited by `admin` on `Mon Mar 31 18:18:17 GMT 2025`
Record UNII	539M941Y9O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NEOCINCHOPHEN

Official Name

English

NSC-34910

Preferred Name

English

ETHYL 6-METHYL-2-PHENYL-4-QUINOLINECARBOXYLATE

Systematic Name

English

neocinchophen [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241