Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C36H72NO8P |
| Molecular Weight | 677.9325 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC
InChI
InChIKey=CITHEXJVPOWHKC-UUWRZZSWSA-N
InChI=1S/C36H72NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-35(38)42-32-34(33-44-46(40,41)43-31-30-37(3,4)5)45-36(39)29-27-25-23-21-19-17-15-13-11-9-7-2/h34H,6-33H2,1-5H3/t34-/m1/s1
| Molecular Formula | C36H72NO8P |
| Molecular Weight | 677.9325 |
| Charge | 0 |
| Count |
|
| Stereochemistry | EPIMERIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/10866960 | http://www.sciencedirect.com/science/article/pii/S1818087614000725
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/10866960 | http://www.sciencedirect.com/science/article/pii/S1818087614000725
1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE (dimyristoyl phosphatidylcholine, DMPC) is a synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes. DMPC is a frequently studied artificial lipid because it undergoes a phase transition at a convenient temperature. Upon cooling below
23.6°C it undergoes a transition from the liquid crystalline phase to the solid rippled phase, characterized by periodic corrugations of the
bilayer.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL5984 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Inactive ingredient | ABELCET Approved UseABELCET is indicated for the treatment of invasive fungal infections in patients who are refractory to or intolerant of conventional amphotericin B therapy. This is based on open-label treatment of patients judged by their physicians to be intolerant to or failing conventional amphotericin B therapy Launch Date2010 |
|||
| Diagnostic | IMAGENT Approved UseReconstituted Imagent (Perflexane Lipid Microspheres) Injectable Suspension is indicated
for use in subjects with suboptimal echocardiograms to opacify the left ventricular chamber
and to improve the delineation of the left ventricular endocardial border Launch Date2002 |
|||
| Primary | Unknown Approved UseUnknown |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
300 mg/dL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31776208/ |
33 mg/kg single, intravenous dose: 33 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
PHOSPHOLIPIDS plasma | Rattus norvegicus population: HEALTHY age: ADULT sex: MALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
703.2 mg × h/dL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31776208/ |
33 mg/kg single, intravenous dose: 33 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
PHOSPHOLIPIDS plasma | Rattus norvegicus population: HEALTHY age: ADULT sex: MALE food status: FASTED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
3.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31776208/ |
33 mg/kg single, intravenous dose: 33 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
PHOSPHOLIPIDS plasma | Rattus norvegicus population: HEALTHY age: ADULT sex: MALE food status: FASTED |
Sample Use Guides
Cholesterol-fed rabbits infused weekly with dimyristoylphosphatidylcholine (DMPC) liposomes (300 mg/kg body weight) for five weeks had significantly decreased aortic cholesterol contents compared with saline-infused cholesterol-fed controls. Atherosclerotic plaque volume, as measured by a type of new magnetic resonance imaging analysis, also decreased significantly after DMPC treatment.
Route of Administration:
Intravenous
In Vitro Use Guide
Curator's Comment: A good correlation between fifty-percent inhibitory concentration (IC(50)) of hybrid liposomes (HL) composed of dimyristoylphosphatidylcholine and polyoxyethylene(n) dodecyl ether on the growth of MOLT-4/IIIB cells (MOLT-4 cells chronically infected with human immunodeficiency virus (HIV)) and the membrane fluidity of HL was obtained.
Unknown
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:52:09 GMT 2023
by
admin
on
Fri Dec 15 15:52:09 GMT 2023
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| Record UNII |
52QK2NZ2T0
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C927
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5459377
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242-085-9
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Dimyristoylphosphatidylcholine
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DTXSID00860227
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52QK2NZ2T0
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CHEMBL1201501
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45240
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18194-24-6
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C61726
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ACTIVE MOIETY |
