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Details

Stereochemistry ABSOLUTE
Molecular Formula C28H37ClO7
Molecular Weight 521.042
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ICOMETASONE ENBUTATE

SMILES

[H][C@@]12C[C@@H](C)[C@](OC(=O)CCC)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]3(Cl)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=OVTRPNSKIPQZEC-NJLPOHDGSA-N
InChI=1S/C28H37ClO7/c1-6-7-24(34)36-28(23(33)15-35-17(3)30)16(2)12-21-20-9-8-18-13-19(31)10-11-25(18,4)27(20,29)22(32)14-26(21,28)5/h10-11,13,16,20-22,32H,6-9,12,14-15H2,1-5H3/t16-,20+,21+,22+,25+,26+,27+,28+/m1/s1

HIDE SMILES / InChI

Molecular Formula C28H37ClO7
Molecular Weight 521.042
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 8 / 8
E/Z Centers 0
Optical Activity UNSPECIFIED

Icometasone (CL09) is a synthetic glucocorticoid corticosteroid. It is a metabolite of Mometasone Furoate. The binding on human serum albumin was shown to be non saturable, suggesting that other proteins were involved in CL09 binding. This binding was demonstrated to be reversible. CL09 was extensively metabolized since no unchanged CL09 was recovered in bile or urine and at least nine metabolites have been detected. It was studied in Europe as an anti-asthmatic agent but investigation is discontinued.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Pharmacokinetics, protein binding and metabolic profile of 3H-icometasone enbutate following intravenous, oral and intratracheal administrations to Sprague-Dawley rats.
1998 Apr
Bioavailability and metabolism of mometasone furoate: pharmacology versus methodology.
2002 Apr
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: 3H-icometasone enbutate
Rats: intravenous (1 mg/kg), oral and intratracheal (2 mg/kg).
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:15:49 GMT 2023
Edited
by admin
on Fri Dec 15 17:15:49 GMT 2023
Record UNII
51DNE9RS3F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ICOMETASONE ENBUTATE
INN  
INN  
Official Name English
CL-09
Code English
icometasone enbutate [INN]
Common Name English
CL09
Code English
9-CHLORO-11.BETA.,17,21-TRIHYDROXY-16.ALPHA.-METHYLPREGNA-1,4-DIENE-3,20-DIONE 17-BUTYRATE 21-ACETATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C521
Created by admin on Fri Dec 15 17:15:49 GMT 2023 , Edited by admin on Fri Dec 15 17:15:49 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C83778
Created by admin on Fri Dec 15 17:15:49 GMT 2023 , Edited by admin on Fri Dec 15 17:15:49 GMT 2023
PRIMARY
EVMPD
SUB08107MIG
Created by admin on Fri Dec 15 17:15:49 GMT 2023 , Edited by admin on Fri Dec 15 17:15:49 GMT 2023
PRIMARY
CAS
103466-73-5
Created by admin on Fri Dec 15 17:15:49 GMT 2023 , Edited by admin on Fri Dec 15 17:15:49 GMT 2023
PRIMARY
SMS_ID
100000083672
Created by admin on Fri Dec 15 17:15:49 GMT 2023 , Edited by admin on Fri Dec 15 17:15:49 GMT 2023
PRIMARY
INN
7049
Created by admin on Fri Dec 15 17:15:49 GMT 2023 , Edited by admin on Fri Dec 15 17:15:49 GMT 2023
PRIMARY
MESH
C112801
Created by admin on Fri Dec 15 17:15:49 GMT 2023 , Edited by admin on Fri Dec 15 17:15:49 GMT 2023
PRIMARY
PUBCHEM
65877
Created by admin on Fri Dec 15 17:15:49 GMT 2023 , Edited by admin on Fri Dec 15 17:15:49 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106296
Created by admin on Fri Dec 15 17:15:49 GMT 2023 , Edited by admin on Fri Dec 15 17:15:49 GMT 2023
PRIMARY
FDA UNII
51DNE9RS3F
Created by admin on Fri Dec 15 17:15:49 GMT 2023 , Edited by admin on Fri Dec 15 17:15:49 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY