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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H29ClO5
Molecular Weight 408.916
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ICOMETASONE

SMILES

[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(Cl)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=NBMKJKDGKREAPL-CXSFZGCWSA-N
InChI=1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

HIDE SMILES / InChI

Molecular Formula C22H29ClO5
Molecular Weight 408.916
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 8 / 8
E/Z Centers 0
Optical Activity UNSPECIFIED

Icometasone (CL09) is a synthetic glucocorticoid corticosteroid. It is a metabolite of Mometasone Furoate. The binding on human serum albumin was shown to be non saturable, suggesting that other proteins were involved in CL09 binding. This binding was demonstrated to be reversible. CL09 was extensively metabolized since no unchanged CL09 was recovered in bile or urine and at least nine metabolites have been detected. It was studied in Europe as an anti-asthmatic agent but investigation is discontinued.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: 3H-icometasone enbutate
Rats: intravenous (1 mg/kg), oral and intratracheal (2 mg/kg).
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 01:54:46 UTC 2023
Edited
by admin
on Sat Dec 16 01:54:46 UTC 2023
Record UNII
2LP8SJ795G
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ICOMETASONE
Common Name English
(11.BETA.,16.ALPHA.)-9-CHLORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE
Systematic Name English
ICOMETHASONE
Common Name English
PREGNA-1,4-DIENE-3,20-DIONE, 9-CHLORO-11,17,21-TRIHYDROXY-16-METHYL-, (11.BETA.,16.ALPHA.)-
Systematic Name English
MOMETASONE FUROATE IMPURITY K [EP IMPURITY]
Common Name English
Code System Code Type Description
FDA UNII
2LP8SJ795G
Created by admin on Sat Dec 16 01:54:47 UTC 2023 , Edited by admin on Sat Dec 16 01:54:47 UTC 2023
PRIMARY
EPA CompTox
DTXSID40196850
Created by admin on Sat Dec 16 01:54:47 UTC 2023 , Edited by admin on Sat Dec 16 01:54:47 UTC 2023
PRIMARY
PUBCHEM
11407187
Created by admin on Sat Dec 16 01:54:47 UTC 2023 , Edited by admin on Sat Dec 16 01:54:47 UTC 2023
PRIMARY
CAS
4647-20-5
Created by admin on Sat Dec 16 01:54:47 UTC 2023 , Edited by admin on Sat Dec 16 01:54:47 UTC 2023
PRIMARY
WIKIPEDIA
Icometasone
Created by admin on Sat Dec 16 01:54:47 UTC 2023 , Edited by admin on Sat Dec 16 01:54:47 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP