Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C28H44NO2 |
| Molecular Weight | 426.6545 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 1 |
SHOW SMILES / InChI
SMILES
CC1=CC(OCCOCC[N+](C)(C)CC2=CC=CC=C2)=CC=C1C(C)(C)CC(C)(C)C
InChI
InChIKey=ULBZAXDVMDGCJQ-UHFFFAOYSA-N
InChI=1S/C28H44NO2/c1-23-20-25(14-15-26(23)28(5,6)22-27(2,3)4)31-19-18-30-17-16-29(7,8)21-24-12-10-9-11-13-24/h9-15,20H,16-19,21-22H2,1-8H3/q+1
| Molecular Formula | C28H44NO2 |
| Molecular Weight | 426.6545 |
| Charge | 1 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Topical paromomycin/methylbenzethonium chloride plus parenteral meglumine antimonate as treatment of American cutaneous leishmaniasis: controlled study. | 1999 Aug |
|
| Randomized, controlled, double-blind trial of topical treatment of cutaneous leishmaniasis with paromomycin plus methylbenzethonium chloride ointment in Guatemala. | 2001 Nov |
Patents
Sample Use Guides
1- Clean the affected area and completely cover with the ointment. A sterile dressing can be used to dress the area. 2- Apply the ointment twice a day, for about 10 days. If full recovery is not achieved, the doctor will consider administration of an additional 10-day course of treatment.
Route of Administration:
Topical
Methylbenzethonium chloride at 0.1 and 0.5 microg/ml inhibited the parasite development by 39.5% and 65.2%. Imiquimod (5-10 microg/ml) combined with either paromomycin (25, 50 and 100 microg/ml) or methylbenzethonium chloride (0.1 and 0.5 microg/ml) showed an anti-leishmanial additive effect.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:38:20 GMT 2023
by
admin
on
Fri Dec 15 18:38:20 GMT 2023
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| Record UNII |
512838GU34
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| Record Status |
Validated (UNII)
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| Record Version |
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512838GU34
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DTXSID20110039
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admin on Fri Dec 15 18:38:20 GMT 2023 , Edited by admin on Fri Dec 15 18:38:20 GMT 2023
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SALT/SOLVATE -> PARENT |
