TALBUTAL

US Previously Marketed

First approved in 1954

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H16N2O3
Molecular Weight	224.2563
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC(C)C1(CC=C)C(=O)NC(=O)NC1=O

InChI

InChIKey=BJVVMKUXKQHWJK-UHFFFAOYSA-N

InChI=1S/C11H16N2O3/c1-4-6-11(7(3)5-2)8(14)12-10(16)13-9(11)15/h4,7H,1,5-6H2,2-3H3,(H2,12,13,14,15,16)

HIDE SMILES / InChI

Molecular Formula	C11H16N2O3
Molecular Weight	224.2563
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14394223 | http://www.druglib.com/activeingredient/talbutal/

Talbutal is a short to intermediate-acting barbiturate, which had been used under brand name Latusate as a sedative and hypnotic, but then this usage was discontinued. It was found, that talbutal binds at a distinct binding site at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. Thus, the post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-A receptor; anion channel 202 Target ID: CHEMBL2093872 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11264449	Positive Allosteric Modulator 179

Conditions

Condition	Modality	Targets	Highest Phase	Product
Sleep disorder 20 Sources: http://www.druglib.com/activeingredient/talbutal/	Primary		Approved 8429	Latusate Approved Use Unknown

T_1/2

Value	Dose	Co-administered	Analyte	Population
15 h REVIEW https://link.springer.com/chapter/10.1007%2F978-94-011-3804-8_20	unknown, unknown		TALBUTAL plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B2-1457	http://www.3bsc.com/index/pro_info.php?id=55173
AHH Chemical co.,ltd	MT-58894	http://www.ahhchemical.com/product/MT-58894.html
Ambinter	Amb22056189	http://www.ambinter.com/reference/22056189
Avantor Inc	75835-294	https://us.vwr.com/store/product/21998648/exempted-drug-of-abuse-reference-standards-restek
Chem Scene	CS-7222	http://www.chemscene.com/115-44-6.html
Finetech	FT-0674795	http://www.finetechnology-ind.com/product/All%20product%20List/115-44-6.html
LGC Standards	LGCFOR3446.00	https://www.lgcstandards.com/US/en/p/LGCFOR3446.00
MedChem Express	HY-U00276	http://www.medchemexpress.com/Talbutal.html
MuseChem	I009696	https://www.musechem.com/product/I009696.html
Parchem	55157	https://www.parchem.com/chemical-supplier-distributor/Talbutal-055157.aspx
Smolecule	S544483	http://www.smolecule.com/products/s544483
THE BioTek	bt-283154	https://www.thebiotek.com/product/inhibitors/bt-283154

PubMed

Title	Date	PubMed
Clinical studies on a new synthetic hypnotic, Win 5095 (lotusate).	1955 Jul	14394223
The postoperative use of demerol-lotusate tablets in orthopedic surgery.	1959 Sep	13851190

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:20:39 GMT 2023` Edited by `admin` on `Fri Dec 15 16:20:39 GMT 2023`
Record UNII	4YIR8202AX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TALBUTAL

Official Name

English

Talbutal [WHO-DD]

Common Name

English

5-Allyl-5-sec-butylbarbituric acid

Systematic Name

English

2,4,6(1H,3H,5H)-PYRIMIDINETRIONE, 5-(1-METHYPROPYL)-5-(2-PROPENYL)-

Common Name

English

TALBUTAL [HSDB]

Common Name

English

LOTUSATE

Brand Name

English

TALBUTAL [MART.]

Common Name

English

TALBUTAL [VANDF]

Common Name

English

talbutal [INN]

Common Name

English

TALBUTAL [MI]

Common Name

English

TALBUTAL [ORANGE BOOK]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C67084