PICLOXYDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H24Cl2N10
Molecular Weight	475.378
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C(NC(=N)NC(=N)N2CCN(CC2)C(=N)NC(=N)NC3=CC=C(Cl)C=C3)C=C1

InChI

InChIKey=YNCLPFSAZFGQCD-UHFFFAOYSA-N

InChI=1S/C20H24Cl2N10/c21-13-1-5-15(6-2-13)27-17(23)29-19(25)31-9-11-32(12-10-31)20(26)30-18(24)28-16-7-3-14(22)4-8-16/h1-8H,9-12H2,(H4,23,25,27,29)(H4,24,26,28,30)

HIDE SMILES / InChI

Molecular Formula	C20H24Cl2N10
Molecular Weight	475.378
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/323454 | https://www.ncbi.nlm.nih.gov/pubmed/3274675 | https://www.moncoinsante.co.uk/vitabact-0-05-collyre-thea-flacon-de-10-ml.html

Picloxydine is a heterocyclic biguanide with antibacterial and antiplaque activity. 0.4% Picloxydine produces a highly significant drop in the number of aerobic organisms. 0.4% Picloxydine is far more effective than 0.2% Picloxydine or chlorhexidine in reducing the total viable count of oral aerobic and anaerobic organisms. It is used to treat superficial eye infections. Picloxydine is also used in eye drops in the topical therapy of trachoma. This drug can cause side effects - local intolerance reactions (temporary irritation, allergic reactions).

Approval Year

Sample Use Guides

In Vivo Use Guide

1 drop, 2-6 times per day

Route of Administration: Topical

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:35:27 GMT 2023` Edited by `admin` on `Fri Dec 15 15:35:27 GMT 2023`
Record UNII	4YC2PY3AEU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PICLOXYDINE

Official Name

English

1,1'-(1,4-PIPERAZINEDIYLBIS(IMIDOCARBONYL))BIS(3-(P-CHLOROPHENYL)GUANIDINE)

Common Name

English

PICLOXYDINE [MI]

Common Name

English

Picloxydine [WHO-DD]

Common Name

English

picloxydine [INN]

Common Name

English

Classification Tree Code System Code

WHO-ATC

S01AX16