NILOFABICIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H20N2O2S
Molecular Weight	340.439
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(N)C=CC=C1CN2C=CC(OCCC3=CC=CS3)=CC2=O

InChI

InChIKey=YCLREGRRHGLOAK-UHFFFAOYSA-N

InChI=1S/C19H20N2O2S/c1-14-15(4-2-6-18(14)20)13-21-9-7-16(12-19(21)22)23-10-8-17-5-3-11-24-17/h2-7,9,11-12H,8,10,13,20H2,1H3

HIDE SMILES / InChI

Molecular Formula	C19H20N2O2S
Molecular Weight	340.439
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21656363 | https://www.ncbi.nlm.nih.gov/pubmed/17875997 | https://www.ncbi.nlm.nih.gov/pubmed/17420210

CG-400549, also known as CG-0549, is an enoyl-(acyl-carrier protein) reductase fabl inhibitor developed by CrystalGenomics for the treatment of compcolicated acute and methicillin-resistant Staphylococcus aureus. CG400549 shows potent antimicrobial activity against 203 S. aureus strains and was more potent than either linezolid or vancomycin. An animal study showed that CG-400549has potential for the treatment of staphylococcal infections in mice and rats

Originator

Approval Year

PubMed

Title	Date	PubMed
Solid state of CG-400549, a novel FabI inhibitor: characterization, dissolution, transformation.	2011 May	21656363

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:35:15 GMT 2023` Edited by `admin` on `Fri Dec 15 16:35:15 GMT 2023`
Record UNII	4X6T64D64X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NILOFABICIN

Official Name

English

nilofabicin [INN]

Common Name

English

2(1H)-PYRIDINONE, 1-((3-AMINO-2-METHYLPHENYL)METHYL)-4-(2-(2-THIENYL)ETHOXY)-

Systematic Name

English

1-((3-AMINO-2-METHYLPHENYL)METHYL)-4-(2-(2-THIENYL)ETHOXY)-2(1H)-PYRIDINONE

Common Name

English

CG400549

Code

English

CG-400549

Code

English

Code System Code Type Description

NCI_THESAURUS

C179108