For day 1 and day 28 of a 28-d repeat dose study at 100 mg/kg (N = 4 per dose) by powder in capsule (PIC). Emesis was not observed in any animal. D159687 was emetic at 600 mg/kg in a single-dose range finding study. Like mouse, dog has the nonprimate Tyr196 amino acid polymorphism in PDE4D. One male and one female monkey were dosed intravenously (IV) with D159687 at 1 mg/kg or orally by gavage (POG) for 5 d at 10 mg/kg in 0.5% HPMC (hydroxypropyl methylcellulose), 0.5% poloxamer 188, 0.4% Tween 80. Emesis was not observed in either monkey. D159687 was emetic at 30 mg/kg in a single-dose range finding study.

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