U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C10H21N
Molecular Weight 155.2804
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LEVOPROPYLHEXEDRINE

SMILES

CN[C@@H](C)CC1CCCCC1

InChI

InChIKey=JCRIVQIOJSSCQD-VIFPVBQESA-N
InChI=1S/C10H21N/c1-9(11-2)8-10-6-4-3-5-7-10/h9-11H,3-8H2,1-2H3/t9-/m0/s1

HIDE SMILES / InChI

Molecular Formula C10H21N
Molecular Weight 155.2804
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Propylhexedrine Hydrochloride is an α-adrenergic sympathomimetic amine that acts as a local vasoconstrictor. It is the active ingredient in some over-the-counter nasal decongestants, typically by intravenous or oral delivery of the nasal decongestant. Propylhexedrine is known under the brand name Benzedrex. Propylhexedrine has also seen use in Europe as an appetite suppressant under the trade name Obesin and in the anticonvulsant preparation barbexaclone its S-isomer PROPYLHEXEDRINE HYDROCHLORIDE, (-)- (levopropylhexedrine or L-propylhexedrine) is bonded with phenobarbital for the purpose of offsetting the barbiturate-induced sedation. Levopropylhexedrine is also used as an anorectic under the brand name Eventin.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Eventin
Primary
Benzedrex
Primary
Benzedrex
Primary
Maliasin
Curative
Eventin

Cmax

ValueDoseCo-administeredAnalytePopulation
1.5 μg/mL
66 mg/kg 1 times / day steady-state, oral
PROPYLHEXEDRINE plasma
Mus musculus

AUC

ValueDoseCo-administeredAnalytePopulation
1.3 μg × h/mL
66 mg/kg 1 times / day steady-state, oral
PROPYLHEXEDRINE plasma
Mus musculus

T1/2

ValueDoseCo-administeredAnalytePopulation
2.5 h
66 mg/kg 1 times / day steady-state, oral
PROPYLHEXEDRINE plasma
Mus musculus

Doses

AEs

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
4R3L4TYV09
Record Status Validated (UNII)
Record Version