MEDAZOMIDE

CN1N=C(CCC1=O)C(N)=O

InChIKey=LXFKHPXXAPOYCC-UHFFFAOYSA-N

InChI=1S/C6H9N3O2/c1-9-5(10)3-2-4(8-9)6(7)11/h2-3H2,1H3,(H2,7,11)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Medazomide (medazonamide) is an antitussive drug.

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cough 106 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5604245 https://www.ncbi.nlm.nih.gov/pubmed/13938444	Primary		Phase I 438	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
BOC Sciences	300-22-1	http://www.bocsci.com/description.asp?cas=300-22-1
eMolecules	37094341	https://orderbb.emolecules.com/search/#?query=37094341
Enamine	BBV-41781761	http://www.enaminestore.com/catalog/BBV-41781761
Enamine	EN300-94794	https://www.enaminestore.com/catalog/EN300-94794
Enamine	Z168362628	https://www.enaminestore.com/blog/real/Z168362628/
mcule	MCULE-4986678253	https://mcule.com/MCULE-4986678253/
MolPort	MolPort-011-960-636	https://www.molport.com/shop/molecule-link/MolPort-011-960-636
Nanjing Pope Bio-tech	NSTH-C028283
Norris Pharm	NSTH-C028283
Toronto Research Chemicals	B498075	https://www.trc-canada.com/product-detail/?CatNum=B498075
UORSY	PB168440096

PubMed

Title	Date	PubMed
[Considerations on antitussive treatments in pediatrics: The use of a new compound: medazonamide].	1967-01-15	5604245
[Controlled clinical experiments with new antitussive drugs. I. Methodological considerations and evaluation of the antitussive activity of medazonamide].	1962-08-15	13938444

Patents

In Vivo Use Guide

Rats: Intraabdominal administration of medazonamide in 5, 10 and 20 mg/kg doses has less anti-cough effect than codeine in the given conditions.

Route of Administration: Intraperitoneal

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:45:25 GMT 2025` Edited by `admin` on `Mon Mar 31 17:45:25 GMT 2025`
Record UNII	4Q1Q4V31K8
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

MEDAZOMIDE

Official Name

English

L-1777

Preferred Name

English

1,4,5,6-TETRAHYDRO-1-METHYL-6-OXO-3-PYRIDAZINECARBOXAMIDE

Systematic Name

English

medazomide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29698