SATRANIDAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H11N5O5S
Molecular Weight	289.268
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C(=NC=C1[N+]([O-])=O)N2CCN(C2=O)S(C)(=O)=O

InChI

InChIKey=FNSHYEAUAUHIMB-UHFFFAOYSA-N

InChI=1S/C8H11N5O5S/c1-10-6(13(15)16)5-9-7(10)11-3-4-12(8(11)14)19(2,17)18/h5H,3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C8H11N5O5S
Molecular Weight	289.268
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17103040 | https://www.ncbi.nlm.nih.gov/pubmed/26748382 | https://www.ncbi.nlm.nih.gov/pubmed/26242010

Satranidazole is a drug that helps to combat a large number of varied health disorders effectively. This drug participated in clinical trials in patients of amebic liver abscess, where it showed a far lower incidence of side effects and had a significantly better tolerance than metronidazole. Besides, satranidazole has been studied an adjunct to scaling and root planning in the treatment of chronic periodontitis. satranidazole has a low polar surface area, high dose, and dosing frequency. Nanosizing with appropriate stabilizers and programmed processing conditions successfully produced SAT-NC with improved pharmaceutic and pharmacokinetic characteristics.

Approval Year

PubMed

Title	Date	PubMed
Determination and evaluation of solubility parameter of satranidazole using dioxane-water system.	2010-09	21695009
Randomized, single-blind, placebo-controlled multicenter trial to compare the efficacy and safety of metronidazole and satranidazole in patients with amebic liver abscess.	2006-12	17103040

Sample Use Guides

In Vivo Use Guide

Twenty-five patients received metronidazole (800 mg TID) and 24 received satranidazole (300 mg TID with placebo at mealtime).

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:18:37 GMT 2025` Edited by `admin` on `Mon Mar 31 18:18:37 GMT 2025`
Record UNII	4N7G8A6439
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SATRANIDAZOLE [MART.]

Preferred Name

English

SATRANIDAZOLE

Official Name

English

Satranidazole [WHO-DD]

Common Name

English

satranidazole [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C277