U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C17H14N2O2
Molecular Weight 278.3053
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BIMAKALIM

SMILES

CC1(C)OC2=C(C=C(C=C2)C#N)C(=C1)N3C=CC=CC3=O

InChI

InChIKey=JTVSKASWNROQQF-UHFFFAOYSA-N
InChI=1S/C17H14N2O2/c1-17(2)10-14(19-8-4-3-5-16(19)20)13-9-12(11-18)6-7-15(13)21-17/h3-10H,1-2H3

HIDE SMILES / InChI

Molecular Formula C17H14N2O2
Molecular Weight 278.3053
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Bimakalim (also known as EMD 52692), a potassium channel opener, was studied for patients with bronchial asthma and with stable angina pectoris. Besides the drug was used against arrhythmias and hypertension. However, the development of bimakalim has been discontinued.

Originator

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
86 patients with angiographic signs of CAD were involved in two randomised, placebo-controlled, double-blind trials with single high (0.1, 0.3 or 0.6 mg) and low (0.025 or 0.05 mg) doses of oral bimakalim. Inhaled bimakalim and placebo were delivered by a Pariboy nebulizer. The doses tested in a cumulative manner were 10, 25, 40 and 100 micrograms (total cumulative dose 175 micrograms), each individual dose given at 60-min intervals
Route of Administration: Other
Substance Class Chemical
Record UNII
4MP5GR4H9L
Record Status Validated (UNII)
Record Version