Ziftomenib

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C33H42F3N9O2S2
Molecular Weight	717.871
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC1=NC(NC2CCN(CC3=CC=C4N(C[C@H](C)N5CCN(CC5)S(C)(=O)=O)C(=CC4=C3C)C#N)CC2)=C6C=C(CC(F)(F)F)SC6=N1

InChI

InChIKey=BGGALFIXXQOTPY-NRFANRHFSA-N

InChI=1S/C33H42F3N9O2S2/c1-21(43-11-13-44(14-12-43)49(4,46)47)19-45-25(18-37)15-27-22(2)23(5-6-29(27)45)20-42-9-7-24(8-10-42)39-30-28-16-26(17-33(34,35)36)48-31(28)41-32(38-3)40-30/h5-6,15-16,21,24H,7-14,17,19-20H2,1-4H3,(H2,38,39,40,41)/t21-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C33H42F3N9O2S2
Molecular Weight	717.871
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 14:41:37 GMT 2023` Edited by `admin` on `Sat Dec 16 14:41:37 GMT 2023`
Record UNII	4MOD1F4ENC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Ziftomenib

Official Name

English

(7S)-8⁴-(methanesulfonyl)-5⁴,7-dimethyl-1²-(methylamino)-1⁶-(2,2,2-trifluoroethyl)-2-aza-1(4)-thieno[2,3-d]pyrimidina-5(5,1)-indola-8(1)-piperazina-3(4,1)-piperidinaoctaphane-5²-carbonitrile

Systematic Name

English

ziftomenib [INN]

Common Name

English

1H-Indole-2-carbonitrile, 4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1-[(2S)-2-[4-(methylsulfonyl)-1-piperazinyl]propyl]-

Systematic Name

English

Menin-Mixed Lineage Leukemia Protein-Protein Interaction Inhibitor KO 539

Common Name

English

4-Methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1-[(2S)-2-[4-(methylsulfonyl)-1-piperazinyl]propyl]-1H-indole-2-carbonitrile

Systematic Name

English

KO539

Code

English

KO-539

Code

English

ZIFTOMENIB [USAN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

697819