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Details

Stereochemistry ABSOLUTE
Molecular Formula C33H42F3N9O2S2
Molecular Weight 717.871
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Ziftomenib

SMILES

CNC1=NC(NC2CCN(CC3=CC=C4N(C[C@H](C)N5CCN(CC5)S(C)(=O)=O)C(=CC4=C3C)C#N)CC2)=C6C=C(CC(F)(F)F)SC6=N1

InChI

InChIKey=BGGALFIXXQOTPY-NRFANRHFSA-N
InChI=1S/C33H42F3N9O2S2/c1-21(43-11-13-44(14-12-43)49(4,46)47)19-45-25(18-37)15-27-22(2)23(5-6-29(27)45)20-42-9-7-24(8-10-42)39-30-28-16-26(17-33(34,35)36)48-31(28)41-32(38-3)40-30/h5-6,15-16,21,24H,7-14,17,19-20H2,1-4H3,(H2,38,39,40,41)/t21-/m0/s1

HIDE SMILES / InChI

Molecular Formula C33H42F3N9O2S2
Molecular Weight 717.871
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 14:41:37 GMT 2023
Edited
by admin
on Sat Dec 16 14:41:37 GMT 2023
Record UNII
4MOD1F4ENC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Ziftomenib
USAN   INN  
Official Name English
(7S)-8⁴-(methanesulfonyl)-5⁴,7-dimethyl-1²-(methylamino)-1⁶-(2,2,2-trifluoroethyl)-2-aza-1(4)-thieno[2,3-d]pyrimidina-5(5,1)-indola-8(1)-piperazina-3(4,1)-piperidinaoctaphane-5²-carbonitrile
Systematic Name English
ziftomenib [INN]
Common Name English
1H-Indole-2-carbonitrile, 4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1-[(2S)-2-[4-(methylsulfonyl)-1-piperazinyl]propyl]-
Systematic Name English
Menin-Mixed Lineage Leukemia Protein-Protein Interaction Inhibitor KO 539
Common Name English
4-Methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1-[(2S)-2-[4-(methylsulfonyl)-1-piperazinyl]propyl]-1H-indole-2-carbonitrile
Systematic Name English
KO539
Code English
KO-539
Code English
ZIFTOMENIB [USAN]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 697819
Created by admin on Sat Dec 16 14:41:37 GMT 2023 , Edited by admin on Sat Dec 16 14:41:37 GMT 2023
Code System Code Type Description
INN
11651
Created by admin on Sat Dec 16 14:41:37 GMT 2023 , Edited by admin on Sat Dec 16 14:41:37 GMT 2023
PRIMARY
USAN
KL-149
Created by admin on Sat Dec 16 14:41:37 GMT 2023 , Edited by admin on Sat Dec 16 14:41:37 GMT 2023
PRIMARY
FDA UNII
4MOD1F4ENC
Created by admin on Sat Dec 16 14:41:37 GMT 2023 , Edited by admin on Sat Dec 16 14:41:37 GMT 2023
PRIMARY
PUBCHEM
138497449
Created by admin on Sat Dec 16 14:41:37 GMT 2023 , Edited by admin on Sat Dec 16 14:41:37 GMT 2023
PRIMARY
SMS_ID
300000020731
Created by admin on Sat Dec 16 14:41:37 GMT 2023 , Edited by admin on Sat Dec 16 14:41:37 GMT 2023
PRIMARY
NCI_THESAURUS
C164227
Created by admin on Sat Dec 16 14:41:37 GMT 2023 , Edited by admin on Sat Dec 16 14:41:37 GMT 2023
PRIMARY
CAS
2134675-36-6
Created by admin on Sat Dec 16 14:41:37 GMT 2023 , Edited by admin on Sat Dec 16 14:41:37 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY