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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H21NO5.ClH
Molecular Weight 367.824
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TAZETTINE HYDROCHLORIDE

SMILES

Cl.CO[C@H]1C[C@@H]2N(C)C[C@@]3(O)OCC4=CC5=C(OCO5)C=C4[C@@]23C=C1

InChI

InChIKey=NYDDUIIWMBRQIM-KKAAJUTMSA-N
InChI=1S/C18H21NO5.ClH/c1-19-9-18(20)17(4-3-12(21-2)6-16(17)19)13-7-15-14(22-10-23-15)5-11(13)8-24-18;/h3-5,7,12,16,20H,6,8-10H2,1-2H3;1H/t12-,16+,17+,18-;/m1./s1

HIDE SMILES / InChI
Molecular Formula C18H21NO5
Molecular Weight 331.363
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Lycorine, galantamine and tazettine has been found as one of the major alkaloid from Amaryllidaceae plants. Tazettine showed affinity to the serotonin reuptake transport protein.

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Phenylethanoid and phenylpropanoid glycosides with melanogenesis inhibitory activity from the flowers of Narcissus tazetta var. chinensis.
2016-01
Biological active compounds from Georgian Galanthus shaoricus.
2011-10
Patents

Patents

CN105384746A
2

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Curator's Comment: Four groups of Amaryllidaceae alkaloids, one of which was tazettine was evaluated in vitro for their ability to inhibit Plasmodium falciparum growth by a high-throughput screening method with a 96-well microtiter plate. It was shown, that tazettine had the least potent activity against P. falciparum (K1).
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 22:41:31 GMT 2025
Edited
by admin
on Mon Mar 31 22:41:31 GMT 2025
Record UNII
4J78BGZ1WP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TAZETTINE HYDROCHLORIDE
MI  
Common Name English
TAZETTINE HYDROCHLORIDE [MI]
Preferred Name English
8H-(1,3)DIOXOLO(6,7)(2)BENZOPYRANO(3,4-C)INDOL-6A(3H)-OL, 4,4A,5,6-TETRAHYDRO-3-METHOXY-5-METHYL-, (3S,4AS,6AS,13BS)-, HYDROCHLORIDE
Systematic Name English
Code System Code Type Description
CAS
6024-65-3
Created by admin on Mon Mar 31 22:41:31 GMT 2025 , Edited by admin on Mon Mar 31 22:41:31 GMT 2025
PRIMARY
FDA UNII
4J78BGZ1WP
Created by admin on Mon Mar 31 22:41:31 GMT 2025 , Edited by admin on Mon Mar 31 22:41:31 GMT 2025
PRIMARY
EPA CompTox
DTXSID90975652
Created by admin on Mon Mar 31 22:41:31 GMT 2025 , Edited by admin on Mon Mar 31 22:41:31 GMT 2025
PRIMARY
PUBCHEM
21127052
Created by admin on Mon Mar 31 22:41:31 GMT 2025 , Edited by admin on Mon Mar 31 22:41:31 GMT 2025
PRIMARY
MERCK INDEX
m10489
Created by admin on Mon Mar 31 22:41:31 GMT 2025 , Edited by admin on Mon Mar 31 22:41:31 GMT 2025
PRIMARY Merck Index
Related Record Type Details
Structure of TAZETTINE
PARENT -> SALT/SOLVATE
NIH
NCATS
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