LURTOTECAN

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C28H30N4O6
Molecular Weight	518.561
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CC[C@@]1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=C6OCCOC6=CC5=C4CN7CCN(C)CC7)C2=O

InChI

InChIKey=RVFGKBWWUQOIOU-NDEPHWFRSA-N

InChI=1S/C28H30N4O6/c1-3-28(35)20-11-22-25-18(14-32(22)26(33)19(20)15-38-27(28)34)17(13-31-6-4-30(2)5-7-31)16-10-23-24(12-21(16)29-25)37-9-8-36-23/h10-12,35H,3-9,13-15H2,1-2H3/t28-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C28H30N4O6
Molecular Weight	518.561
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description

Lurtotecan is a semisynthetic analog of camptothecin with antineoplastic activity. It is an inhibitor of DNA topoisomerase I. Liposomal formulation of lurtotecan was being studied in the treatment of cancer. Lurtotecan development has been discontinued.

Originator

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
DNA topoisomerase I 59	Inhibitor 8,297

PubMed

Show entries

Title	Date	PubMed
Phase I and pharmacologic study of liposomal lurtotecan, NX 211: urinary excretion predicts hematologic toxicity.	2002 Mar 1	11870164
Gateways to clinical trials.	2003 Jul-Aug	12949633
[A symphony for the camptothecins].	2003 Mar	12801826
OSI-211, a novel liposomal topoisomerase I inhibitor, is active in SCID mouse models of human AML and ALL.	2003 Nov	12859997
Are there any better camptothecins than the ones we have?	2003 Oct	16258452

Showing 1 to 5 of 11 entries

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Patents

Substance Class	Chemical
Record UNII	4J1L80T08I
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

LURTOTECAN

Official Name

English

(8S)-8-ETHYL-2,3-DIHYDRO-8-HYDROXY-15-((4-METHYL-1-PIPERAZINYL)METHYL)-11H-P-DIOXINO(2,3-G)PYRANO(3',4':6,7)INDOLIZINO(1,2-B)QUINOLINE-9,12(8H,14H)-DIONE

Common Name

English

11H-1,4-DIOXINO(2,3-G)PYRANO(3',4':6,7)INDOLIZINO(1,2-B)QUINOLINE-9,12(8H,14H)-DIONE, 8-ETHYL-2,3-DIHYDRO-8-HYDROXY-15-((4-METHYL-1-PIPERAZINYL)METHYL)-, (S)

Common Name

English

lurtotecan [INN]

Common Name

English

Lurtotecan [WHO-DD]

Common Name

English

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