BUTANSERIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H26FN3O3
Molecular Weight	423.4799
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=C1)C(=O)C2CCN(CCCCN3C(=O)NC4=C(C=CC=C4)C3=O)CC2

InChI

InChIKey=MLDQSYUQSLUEPG-UHFFFAOYSA-N

InChI=1S/C24H26FN3O3/c25-19-9-7-17(8-10-19)22(29)18-11-15-27(16-12-18)13-3-4-14-28-23(30)20-5-1-2-6-21(20)26-24(28)31/h1-2,5-10,18H,3-4,11-16H2,(H,26,31)

HIDE SMILES / InChI

Molecular Formula	C24H26FN3O3
Molecular Weight	423.4799
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6148393 | https://www.ncbi.nlm.nih.gov/pubmed/2872314

Butanserin is the potent and selective alpha 1-adrenoceptor antagonist.

Originator

Approval Year

PubMed

Title	Date	PubMed
Antagonism of the antidiarrhoeal effect of clonidine and the lethal effect of noradrenaline in rats: a reliable procedure to evaluate the in-vivo alpha 1- and alpha 2-blocking activity of drugs?	1984 Aug	6148393
Characterization of flufylline, fluprofylline, ritanserin, butanserin and R 56413 with respect to in-vivo alpha 1-,alpha 2- and 5-HT2-receptor antagonism and in-vitro affinity for alpha 1-,alpha 2- and 5-HT2-receptors: comparison with ketanserin.	1986 May	2872314

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:13:26 GMT 2023` Edited by `admin` on `Fri Dec 15 16:13:26 GMT 2023`
Record UNII	4I933V848G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BUTANSERIN

Official Name

English

butanserin [INN]

Common Name

English

3-(4-(4-(P-FLUOROBENZOYL)PIPERIDINO)BUTYL)-2,4(1H,3H)QUINAZOLINEDIONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66885