DICLOXACILLIN SODIUM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H16Cl2N3O5S.Na.H2O
Molecular Weight	510.323
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.[Na+].CC1=C(C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C([O-])=O)C(=NO1)C4=C(Cl)C=CC=C4Cl

InChI

InChIKey=SIGZQNJITOWQEF-VICXVTCVSA-M

InChI=1S/C19H17Cl2N3O5S.Na.H2O/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24;;/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1

HIDE SMILES / InChI

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C19H17Cl2N3O5S
Molecular Weight	470.326
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.drugs.com/pro/dicloxacillin.html
Curator's Comment: description was created based on several sources, including https://www.drugbank.ca/drugs/DB00485 | https://www.ncbi.nlm.nih.gov/pubmed/6559051 | https://www.ncbi.nlm.nih.gov/pubmed/3923593 | https://www.ncbi.nlm.nih.gov/pubmed/20308386

Dicloxacillin sodium USP is a semisynthetic antibiotic substance which resists destruction by the enzyme penicillinase (beta-lactamase). It is monosodium (2S,5R,6R)-6-[3-(2,6-dichlorophenyl)-5-methyl-4- isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0]heptane-2-carboxylate monohydrate. Like other β-lactam antibiotics, dicloxacillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria. Dicloxacillin is administered orally via capsule form or powder for reconstitution.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Penicillin-binding protein 31 Target ID: CHEMBL2362973 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7447421	Inhibitor 8504
peptidoglycan biosynthetic process 6 Target ID: GO:0009252 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6559051	Inhibitor 8504

Conditions

Condition	Modality	Highest Phase	Product
Infections caused by penicillinase-producing staphylococci 8 Sources: https://www.drugs.com/pro/dicloxacillin.html	Curative	Approved 8583	PATHOCIL Approved Use Indications and Usage. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Dicloxacillin sodium capsules USP and other antibacterial drugs, Dicloxacillin sodium capsules USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Dicloxacillin is indicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug. Cultures and susceptibility tests should be performed initially to determine the causative organisms and their sensitivity to the drug (see CLINICAL PHARMACOLOGY – Susceptibility Plate Testing). Dicloxacillin may be used to initiate therapy in suspected cases of resistant staphylococcal infections prior to the availability of laboratory test results. The penicillinase-resistant penicillins should not be used in infections caused by organisms susceptible to penicillin G. If the susceptibility tests indicate that the infection is due to an organism other than a resistant staphylococcus, therapy should not be continued with a penicillinase-resistant penicillin. Launch Date 1968
Bronchitis 51 Sources: https://www.drugs.com/pro/dicloxacillin.html	Curative	Approved 8583	PATHOCIL Approved Use Indications and Usage. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Dicloxacillin sodium capsules USP and other antibacterial drugs, Dicloxacillin sodium capsules USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Dicloxacillin is indicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug. Cultures and susceptibility tests should be performed initially to determine the causative organisms and their sensitivity to the drug (see CLINICAL PHARMACOLOGY – Susceptibility Plate Testing). Dicloxacillin may be used to initiate therapy in suspected cases of resistant staphylococcal infections prior to the availability of laboratory test results. The penicillinase-resistant penicillins should not be used in infections caused by organisms susceptible to penicillin G. If the susceptibility tests indicate that the infection is due to an organism other than a resistant staphylococcus, therapy should not be continued with a penicillinase-resistant penicillin. Launch Date 1968
Pneumonia 91 Sources: https://www.drugs.com/dosage/dicloxacillin.html	Curative	Approved 8583	PATHOCIL Approved Use Indications and Usage. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Dicloxacillin sodium capsules USP and other antibacterial drugs, Dicloxacillin sodium capsules USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Dicloxacillin is indicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug. Cultures and susceptibility tests should be performed initially to determine the causative organisms and their sensitivity to the drug (see CLINICAL PHARMACOLOGY – Susceptibility Plate Testing). Dicloxacillin may be used to initiate therapy in suspected cases of resistant staphylococcal infections prior to the availability of laboratory test results. The penicillinase-resistant penicillins should not be used in infections caused by organisms susceptible to penicillin G. If the susceptibility tests indicate that the infection is due to an organism other than a resistant staphylococcus, therapy should not be continued with a penicillinase-resistant penicillin. Launch Date 1968

C_max

Value	Dose	Analyte	Population
17 μg/mL DRUG LABEL https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=65c3e99b-ec77-416c-ad70-596d6f0a9c31&type=display	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:	DICLOXACILLIN plasma	Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN
13.62 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26527863	0.25 g single, oral dose: 0.25 g route of administration: Oral experiment type: SINGLE co-administered:	DICLOXACILLIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
24.28 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26527863	0.5 g single, oral dose: 0.5 g route of administration: Oral experiment type: SINGLE co-administered:	DICLOXACILLIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
45.02 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26527863	1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered:	DICLOXACILLIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
79.97 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26527863	2 g single, oral dose: 2 g route of administration: Oral experiment type: SINGLE co-administered:	DICLOXACILLIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Analyte	Population
32.78 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26527863	0.25 g single, oral dose: 0.25 g route of administration: Oral experiment type: SINGLE co-administered:	DICLOXACILLIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
62.43 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26527863	0.5 g single, oral dose: 0.5 g route of administration: Oral experiment type: SINGLE co-administered:	DICLOXACILLIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
110.93 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26527863	1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered:	DICLOXACILLIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
207.4 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26527863	2 g single, oral dose: 2 g route of administration: Oral experiment type: SINGLE co-administered:	DICLOXACILLIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Analyte	Population
0.7 h DRUG LABEL https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=65c3e99b-ec77-416c-ad70-596d6f0a9c31&type=display	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:	DICLOXACILLIN plasma	Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN
1.38 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26527863	0.25 g single, oral dose: 0.25 g route of administration: Oral experiment type: SINGLE co-administered:	DICLOXACILLIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
1.44 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26527863	0.5 g single, oral dose: 0.5 g route of administration: Oral experiment type: SINGLE co-administered:	DICLOXACILLIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
1.51 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26527863	1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered:	DICLOXACILLIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
1.71 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26527863	2 g single, oral dose: 2 g route of administration: Oral experiment type: SINGLE co-administered:	DICLOXACILLIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

F_unbound

Value	Dose	Co-administered	Analyte	Population
3% DRUG LABEL https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=65c3e99b-ec77-416c-ad70-596d6f0a9c31&type=display	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:		DICLOXACILLIN plasma	Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
25 mg/kg multiple, oral Dose: 25 mg/kg Route: oral Route: multiple Dose: 25 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/8396081/	unhealthy, 2-12 Health Status: unhealthy Age Group: 2-12 Sources: https://pubmed.ncbi.nlm.nih.gov/8396081/	Other AEs: Abdominal pain, Vomiting... Other AEs: Abdominal pain (mild, 1 patient) Vomiting (mild, 1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/8396081/
2 g single, oral Dose: 2 g Route: oral Route: single Dose: 2 g Sources: https://pubmed.ncbi.nlm.nih.gov/26527863/	healthy, 22.2 Health Status: healthy Age Group: 22.2 Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/26527863/	Sources: https://pubmed.ncbi.nlm.nih.gov/26527863/
0.5 g 4 times / day single, oral Dose: 0.5 g, 4 times / day Route: oral Route: single Dose: 0.5 g, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/26527863/	healthy, 22.3 Health Status: healthy Age Group: 22.3 Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/26527863/	Sources: https://pubmed.ncbi.nlm.nih.gov/26527863/

AEs

AE	Significance	Dose	Population
Abdominal pain	mild, 1 patient	25 mg/kg multiple, oral Dose: 25 mg/kg Route: oral Route: multiple Dose: 25 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/8396081/	unhealthy, 2-12 Health Status: unhealthy Age Group: 2-12 Sources: https://pubmed.ncbi.nlm.nih.gov/8396081/
Vomiting	mild, 1 patient	25 mg/kg multiple, oral Dose: 25 mg/kg Route: oral Route: multiple Dose: 25 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/8396081/	unhealthy, 2-12 Health Status: unhealthy Age Group: 2-12 Sources: https://pubmed.ncbi.nlm.nih.gov/8396081/

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inducer 1087	inducer 440	inducer 109

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
P-gp 1741 BSEP 550	P-gp 2052	CYP2C19 329 CYP1A2 832

Drug as perpetrator

Target	Modality	Activity	Clinical evidence
P-gp 1932	inhibitor 4027 Sources: https://accpjournals.onlinelibrary.wiley.com/doi/abs/10.1592/phco.28.7.883 Page: abstract	no
CYP1A2 2333	inducer 1966 Sources: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.13467 Page: 516.0	unlikely
CYP2D6 2546	inducer 1966 Sources: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.13467 Page: 517.0	unlikely
BSEP 554	inhibitor 4027 Sources: https://pubs.rsc.org/no/content/articlelanding/2017/mb/c6mb00744a/unauth#!divAbstract Page: 20.0	yes
CYP2C9 2497	inducer 1966 Sources: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.13467 Page: 516.0	yes
CYP3A4 2633	inducer 1966 Sources: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.13467 Page: 516.0	yes
CYP2C19 2141	inducer 1966 Sources: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.13467 Page: 516.0	yes	yes (co-administration study) Comment: dicloxacillin decreased omeprazole AUC 67%, Cmax 60% Sources: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.13467 Page: 516.0

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
P-gp 2052	substrate 4014 Sources: https://link.springer.com/article/10.1023/A:1015191511817 Page: 457.0	yes		yes (co-administration study) Comment: ketoconazole decreased flux of dicloxacillin Sources: https://link.springer.com/article/10.1023/A:1015191511817 Page: 457.0

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:4511	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4511
ChemicalBook	CB6704937	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB6704937
ZINC	ZINC000003978006	http://zinc15.docking.org/substances/ZINC000003978006

PubMed

Title	Date	PubMed
Antibiotic resistance of lactic acid bacteria and Bifidobacterium spp. isolated from dairy and pharmaceutical products.	2007-04-01	17198739
Identification and characterization of degradation products of dicloxacillin in bulk drug and pharmaceutical dosage forms.	2007-03-12	17125952
Oral beta-lactams applied to uncomplicated infections of skin and skin structures.	2007-03	17292581
Characterisation of KLUA-9, a beta-lactamase from extended-spectrum cephalosporin-susceptible Kluyvera ascorbata, and genetic organisation of bla(KLUA-9).	2007-03	17196371
Heterogeneity of human adipose blood flow.	2007-01-20	17239252
Analysis of different beta-lactams antibiotics in pharmaceutical preparations using micellar electrokinetic capillary chromatography.	2007-01-17	16978821
Direct extraction of penicillin G and derivatives from aqueous samples using a stoichiometrically imprinted polymer.	2007-01-15	17222039
Determination of antimicrobials in sludge from infiltration basins at two artificial recharge plants by pressurized liquid extraction-liquid chromatography-tandem mass spectrometry.	2006-10-13	16822516
In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains.	2006-10-12	17034644
Clinical manifestations and outcome in Staphylococcus aureus endocarditis among injection drug users and nonaddicts: a prospective study of 74 patients.	2006-09-11	16965625
Spectrophotometric study of the reaction mechanism between DDQ as pi-acceptor and potassium iodate and flucloxacillin and dicloxacillin drugs and their determination in pure and in dosage forms.	2006-09	16876467
Pseudomonas aeruginosa otochondritis complicating localized cutaneous leishmaniasis: prevention of mutilation by early antibiotic therapy.	2006-08	16896131
Surface and bulk properties of two anionic amphiphilic penicillins in a selective solvent.	2006-07-20	16836332
Development of a validated HPLC method for the determination of four penicillin antibiotics in pharmaceuticals and human biological fluids.	2006-07	16922270
Spectrophotometric determination of flucloxacillin and dicloxacillin in pure and dosage forms.	2006-05-01	16431153
Influence of SDS and two anionic hydrotropes on the micellized state of the triblock copolymer E71G7E71.	2006-04-15	16242706
Positive effect of natural and negatively charged cyclodextrins on the stabilization of penicillins towards beta-lactamase degradation due to inclusion and external guest-host association. An NMR and MS study.	2006-04-07	16557318
Molecular engineering of fluorescent penicillins for molecularly imprinted polymer assays.	2006-03-15	16536441
Placental transfer of antibiotics administered to the mother: a review.	2006-02	16502764
Efficient approach for the reliable quantification and confirmation of antibiotics in water using on-line solid-phase extraction liquid chromatography/tandem mass spectrometry.	2006-01-20	16309690
Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat.	2006-01-06	16398929
Recurrent staphylococcal conjunctivitis associated with facial impetigo contagiosa.	2006-01	16386997
Clonal spread of Staphylococcus aureus with reduced susceptibility to oxacillin in a dermatological hospital unit.	2006	16710581
Thermodynamic study of the effect of ethanol on two amphiphilic penicillins.	2005-12-01	16853954
Diagnosis and management of staphylococcal infections of vascular grafts and stents.	2005-12	16271063
Diagnosis and management of staphylococcal infections of pacemakers and cardiac defibrillators.	2005-12	16271062
Antibiotics currently used in the treatment of infections caused by Staphylococcus aureus.	2005-12	16271060
Cheilitis glandularis in an African-American woman: response to antibiotic therapy.	2005-11-09	16276162
Influence of sub-inhibitory concentrations of antimicrobial agents on biofilm formation in indwelling medical devices.	2005-11	16353125
Development of a novel and automated fluorescent immunoassay for the analysis of beta-lactam antibiotics.	2005-08-24	16104778
Catheter-related septic thrombophlebitis of the great central veins successfully treated with low-dose streptokinase thrombolysis and antimicrobials.	2005-08-22	16111500
Rapidly growing mycobacteria in King Chulalongkorn Memorial Hospital and review of the literature in Thailand.	2005-08	16404850
Comparative assessment of antibiotic susceptibility of coagulase-negative staphylococci in biofilm versus planktonic culture as assessed by bacterial enumeration or rapid XTT colorimetry.	2005-08	15980094
Risk of cholestatic liver disease associated with flucloxacillin and flucloxacillin prescribing habits in the UK: cohort study using data from the UK General Practice Research Database.	2005-07	15963097
Methicillin-resistant Staphylococcus aureus in community-acquired skin infections.	2005-06	15963289
Biodegradable polymer releasing antibiotic developed for drainage catheter of cerebrospinal fluid: in vitro results.	2005-04	15832004
Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics.	2005-04	15778422
Confirmatory and quantitative analysis of beta-lactam antibiotics in bovine kidney tissue by dispersive solid-phase extraction and liquid chromatography-tandem mass spectrometry.	2005-03-01	15732933
[Treatment of chronic bovine endometritis and factors for treatment success].	2005-01	15714870
Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial.	2005-01	15620935
Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.	2005-01	15567297
Necrotizing surgical site infection after tension-free vaginal tape.	2004-12	15572489
Laser-mediated photodynamic therapy of actinic cheilitis.	2004-11-24	15552607
Interactions of two amphiphilic penicillins with myoglobin in aqueous buffered solutions: a thermodynamic and spectroscopy study.	2004-11-09	15530034
The relationship between inhibition of bacterial adhesion to a solid surface by sub-MICs of antibiotics and subsequent development of a biofilm.	2004-11-05	15950124
Cases from the aerospace medicine residents' teaching file: furunculosis.	2004-11	15559005
Methicillin-resistant Staphylococcus aureus in Europe, 1999-2002.	2004-09	15498166
Application of ion-exchange cartridge clean-up in food analysis. VI. Determination of six penicillins in bovine tissues by liquid chromatography-electrospray ionization tandem mass spectrometry.	2004-07-09	15296394
Effect of dicloxacillin, oxacillin, and nafcillin upon staphylococcal population and rate of healing of soft-tissue lesions.	1966	5985303
Clinical, laboratory, and pharmacological studies of dicloxacillin.	1966	5982342

Patents

Sample Use Guides

In Vivo Use Guide

Usual Adult Dose for Bronchitis: 250 to 500 mg orally every 6 hours for 10 days, depending on the nature and severity of the infection. Usual Adult Dose for Pneumonia: 500 mg orally every 6 hours for up to 21 days, depending on the nature and severity of the infection.

Route of Administration: Oral

In Vitro Use Guide

Bacteria strains ATCC 25923 and E19977 at a density of 10-6 Colony-forming unit /ml were exposed to Dicloxacillin concentrations that varied over a wide range (to obtain a full description of the pharmacological response), and quantification of the numbers of Colony-forming unit was performed after 5 and 24 h of incubation. The MICs of Dicloxacillin at pH 7.4 was 0.125 mg/liter (ATCC 25923) and 0.5 mg/liter (E19977).

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:55:54 GMT 2025` Edited by `admin` on `Mon Mar 31 17:55:54 GMT 2025`
Record UNII	4HZT2V9KX0
Record Status	`Validated (UNII)`
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Name

Type

Language

DICLOXACILLIN SODIUM

Official Name

English

DICLOXACILLIN SODIUM MONOHYDRATE

Preferred Name

English

DICLOXACILLINUM NATRICUM [WHO-IP LATIN]

Common Name

English

P-1011

Code

English

DICLOXACILLIN SODIUM [USP-RS]

Common Name

English

DICLOXACILLIN SODIUM [ORANGE BOOK]

Common Name

English

DICLOXACILLIN SODIUM [VANDF]

Common Name

English

DICLOXACILLIN SODIUM SALT MONOHYDRATE

Common Name

English

SODIUM DICLOXACILLIN MONOHYDRATE

Common Name

English

NSC-756726

Code

English

DICLOXACILLIN SODIUM [USP IMPURITY]

Common Name

English

DICLOXACILLIN SODIUM [WHO-IP]

Common Name

English

DICLOXACILLIN SODIUM HYDRATE [JAN]

Common Name

English

DICLOXACILLIN SODIUM [USAN]

Common Name

English

DICLOXACILLIN SODIUM SALT MONOHYDRATE [MI]

Common Name

English

DYNAPEN

Brand Name

English

DYCILL

Brand Name

English

Monosodium (2S,5R,6R)-6-[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrate

Systematic Name

English

DICLOXACILLIN SODIUM [MART.]

Common Name

English

DICLOXACILLIN SODIUM MONOHYDRATE [GREEN BOOK]

Common Name

English

SODIUM DICLOXACILLIN

Common Name

English

DICLOXACILLIN SODIUM [USP MONOGRAPH]

Common Name

English

Dicloxacillin sodium monohydrate [WHO-DD]

Common Name

English

DICLOXACILLIN SODIUM [EP MONOGRAPH]

Common Name

English

4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID, 6-(((3-(2,6-DICHLOROPHENYL)-5-METHYL-4-ISOXAZOLYL)CARBONYL)AMINO)-3,3-DIMETHYL-7-OXO-, MONOSODIUM SALT, MONOHYDRATE, (2S-(2.ALPHA.,5.ALPHA.,6.BETA.))-

Common Name

English

PATHOCIL

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1500