U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 17:55:09 GMT 2023
Edited
by admin
on Sat Dec 16 17:55:09 GMT 2023
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG2
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
4EQZ6YO2HI
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
DENOSUMAB
EMA EPAR   INN   MART.   MI   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
AMG-162
Code English
DENOSUMAB [EMA EPAR]
Common Name English
XGEVA
Brand Name English
IMMUNOGLOBULIN G2, ANTI-(HUMAN RANK LIGAND) (HUMAN MONOCLONAL AMG162 HEAVY CHAIN), DISULFIDE WITH HUMAN MONOCLONAL AMG162 LIGHT CHAIN, DIMER
Common Name English
DENOSUMAB [MI]
Common Name English
IMMUNOGLOBULIN G2, ANTI-(HUMAN RANK LIGAND) (HUMAN MONOCLONAL AMG162 HEAVY CHAIN), DISULPHIDE WITH HUMAN MONOCLONAL AMG162 LIGHT CHAIN, DIMER
Common Name English
AMG162
Code English
DENOSUMAB [VANDF]
Common Name English
IMMUNOGLOBULIN G2, ANTI-(HUMAN OSTEOCLAST DIFFERENTIATION FACTOR) (HUMAN MONOCLONAL AMG162 HEAVY CHAIN), DISULPHIDE WITH HUMAN MONOCLONAL AMG162 LIGHT CHAIN, DIMER
Common Name English
Denosumab [WHO-DD]
Common Name English
denosumab [INN]
Common Name English
DENOSUMAB [JAN]
Common Name English
PROLIA
Brand Name English
DENOSUMAB [USAN]
Common Name English
DENOSUMAB [MART.]
Common Name English
IMMUNOGLOBULIN G2, ANTI-(HUMAN OSTEOCLAST DIFFERENTIATION FACTOR) (HUMAN MONOCLONAL AMG162 HEAVY CHAIN), DISULFIDE WITH HUMAN MONOCLONAL AMG162 LIGHT CHAIN, DIMER
Common Name English
DENOSUMAB [PURPLE BOOK CDER]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C20401
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
EMA ASSESSMENT REPORTS XGEVA (AUTHORIZED: NEOPLASM METASTASIS)
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
FDA ORPHAN DRUG 324110
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
EMA ASSESSMENT REPORTS PROLIA (AUTHORIZED: OSTEOPOROSIS, POSTMENOPAUSAL)
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
FDA ORPHAN DRUG 798920
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
EMA ASSESSMENT REPORTS PROLIA (AUTHORIZED: BONE RESORPTION)
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
NCI_THESAURUS C129822
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
NDF-RT N0000187055
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
FDA ORPHAN DRUG 404213
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
LIVERTOX NBK548424
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
EMA ASSESSMENT REPORTS XGEVA (AUTHORIZED: FRACTURES, BONE)
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
WHO-VATC QM05BX04
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
WHO-ATC M05BX04
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
Code System Code Type Description
NDF-RT
N0000187054
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY RANK Ligand Blocking Activity [MoA]
CAS
615258-40-7
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
DRUG CENTRAL
4965
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
ChEMBL
CHEMBL1237023
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
IUPHAR
6886
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
EVMPD
SUB29173
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
FDA UNII
4EQZ6YO2HI
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
SMS_ID
100000090712
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
DRUG BANK
DB06643
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
LACTMED
Denosumab
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
USAN
QQ-76
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
RXCUI
993449
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY RxNorm
DAILYMED
4EQZ6YO2HI
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
INN
8653
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
NCI_THESAURUS
C61313
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
WIKIPEDIA
DENOSUMAB
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
MERCK INDEX
m4167
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY Merck Index
MESH
C494392
Created by admin on Sat Dec 16 17:55:10 GMT 2023 , Edited by admin on Sat Dec 16 17:55:10 GMT 2023
PRIMARY
From To
1_22 1_96
1_136 3_215
1_149 1_205
1_224 2_224
1_225 2_225
1_228 2_228
1_231 2_231
1_262 1_322
1_368 1_426
2_22 2_96
2_136 4_215
2_149 2_205
2_262 2_322
2_368 2_426
3_23 3_89
3_135 3_195
4_23 4_89
4_135 4_195
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_298
N 2_298
Related Record Type Details
SUB_CONCEPT->SUBSTANCE
BIOSIMILAR -> PARENT
SUB_CONCEPT->SUBSTANCE
BIOSIMILAR -> PARENT
BIOSIMILAR -> PARENT
TARGET -> INHIBITOR
BIOSIMILAR -> PARENT
TARGET -> INHIBITOR
Denosumab is a fully human monoclonal antibody that binds to RANKL, preventing it from binding its receptor RANK, and thereby inhibiting formation, action, and survival of osteoclasts
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:FORMULA CHEMICAL