DENOSUMAB

Approval Year

Substance Class	Protein
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG2
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	4EQZ6YO2HI
Record Status	`Validated (UNII)`
Record Version

Related Record	Type
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Name

Type

Language

DENOSUMAB

Official Name

English

AMG-162

Code

English

DENOSUMAB [EMA EPAR]

Common Name

English

XGEVA

Brand Name

English

IMMUNOGLOBULIN G2, ANTI-(HUMAN RANK LIGAND) (HUMAN MONOCLONAL AMG162 HEAVY CHAIN), DISULFIDE WITH HUMAN MONOCLONAL AMG162 LIGHT CHAIN, DIMER

Common Name

English

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Classification Tree

Code System

Code

Biological Agent

NCI_THESAURUS

C20401

NEOPLASTIC PROCESSES

EMA ASSESSMENT REPORTS

XGEVA (AUTHORIZED: NEOPLASM METASTASIS)

Designated/Approved

FDA ORPHAN DRUG

324110

OSTEOPOROSIS

EMA ASSESSMENT REPORTS

PROLIA (AUTHORIZED: OSTEOPOROSIS, POSTMENOPAUSAL)

Designated

FDA ORPHAN DRUG

798920

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Code System

Code

Type

Description

NDF-RT

N0000187054

PRIMARY

RANK Ligand Blocking Activity [MoA]

CAS

615258-40-7

PRIMARY

DRUG CENTRAL

4965

PRIMARY

ChEMBL

CHEMBL1237023

PRIMARY

IUPHAR

6886

PRIMARY

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Subunit 0

Subunit 1

Subunit 2

Subunit 3

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From	To
1_22	1_96
1_136	3_215
1_149	1_205
1_224	2_224
1_225	2_225

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Glycosylation Type

MAMMALIAN

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Glycosylation Link Type	Site
N	1_298
N	2_298

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Related Record

Type

Details

TK-006

SUB_CONCEPT->SUBSTANCE

Amount:

DENOSUMAB BIOSIMILAR (QL-1206)

BIOSIMILAR -> PARENT

DENOSUMAB BIOSIMILAR (QL-1206)

SUB_CONCEPT->SUBSTANCE

DENOSUMAB BIOSIMILAR (CT-P41)

BIOSIMILAR -> PARENT

Amount:

DENOSUMAB BIOSIMILAR (HLX-14)

BIOSIMILAR -> PARENT

Amount:

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Related Record

Type

Details


					4EQZ6YO2HI

DENOSUMAB

ACTIVE MOIETY

Amount:

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C6404H9940O1996N1728S50
MOL_WEIGHT:FORMULA	CHEMICAL	FORMULA 144720 Da (average)

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