NOXYTIOLIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3H8N2OS
Molecular Weight	120.173
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC(=S)NCO

InChI

InChIKey=JLMHZVYLAQPMOZ-UHFFFAOYSA-N

InChI=1S/C3H8N2OS/c1-4-3(7)5-2-6/h6H,2H2,1H3,(H2,4,5,7)

HIDE SMILES / InChI

Molecular Formula	C3H8N2OS
Molecular Weight	120.173
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/3142635
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/3142634 | http://www.ncbi.nlm.nih.gov/pubmed/3097078 | http://www.ncbi.nlm.nih.gov/pubmed/35068 | http://www.ncbi.nlm.nih.gov/pubmed/5835451

Noxythiolin is an antimicrobial agent. It can be used for irrigation procedures with noxythiolin solution to reduce the risk of sepsis in patients undergoing percutaneous drainage procedures. It seems mechanism of action is based on ability of noxythiolin to decompose in solution to liberate most of its formaldehyde.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
thyroid hormone generation 1 Target ID: GO:0006590 Sources: http://www.ncbi.nlm.nih.gov/pubmed/2060892	Inhibitor 8297	9.0 µM [IC50]
Pathogenic Escherichia coli infection 1 Target ID: map05130 Sources: http://www.ncbi.nlm.nih.gov/pubmed/2904994	Inhibitor 8297
Staphylococcus aureus infection 1 Target ID: map05150 Sources: http://www.ncbi.nlm.nih.gov/pubmed/2904994	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Empyema 2 Sources: http://www.ncbi.nlm.nih.gov/pubmed/6795589	Preventing		Basic research	Unknown Approved Use Unknown
Peritonitis 22 Sources: http://www.ncbi.nlm.nih.gov/pubmed/35068	Preventing		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Release of formaldehyde from polynoxylin and noxythiolin.	1965 Sep	5835451
An investigation of the in vitro anti-bacterial activity of noxythiolin against 1,000 pathogenic bacterial isolates.	1986 Apr	3086387
[Adjuvant treatment of tubal surgery. Randomized prospective study of systemically administered corticoids and noxythiolin].	1989	2515220
Comparative studies on the effect of noxythiolin and other thioureas on the thyroid using in vitro and in vivo models of thyroid function.	1991 May	2060892
Activity of disinfectants against Gram-negative bacilli isolated from patients undergoing lung transplantation for cystic fibrosis.	2002 Nov	12431498

Patents

Sample Use Guides

In Vivo Use Guide

1-2.5 % solution

Route of Administration: Irrigation

In Vitro Use Guide

Noxythiolin (Noxyflex-S) inhibited iodide organification (thyroid hormone synthesis) by cultured porcine thyrocytes in vitro after 5 hr (IC50 approx. 9.0 microM)

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:55:53 UTC 2023` Edited by `admin` on `Sat Dec 16 16:55:53 UTC 2023`
Record UNII	4DN3AF1FU6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NOXYTIOLIN

Official Name

English

Noxytiolin [WHO-DD]

Common Name

English

NOXYTIOLIN [MART.]

Common Name

English

NOXYTHIOLIN

Common Name

English

1-HYDROXYMETHYL-3-METHYL-2-THIOUREA

Systematic Name

English

noxytiolin [INN]

Common Name

English

NOXYTHIOLIN [MI]

Common Name

English

NOXYFLEX

Brand Name

English

Classification Tree Code System Code

WHO-ATC

B05CA07