DIVAPLON

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H17N3O2
Molecular Weight	295.3358
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1=C(C)N2C=C(N=C2N=C1OC)C(=O)C3=CC=CC=C3

InChI

InChIKey=NRJVHCSYLGLURI-UHFFFAOYSA-N

InChI=1S/C17H17N3O2/c1-4-13-11(2)20-10-14(18-17(20)19-16(13)22-3)15(21)12-8-6-5-7-9-12/h5-10H,4H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C17H17N3O2
Molecular Weight	295.3358
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800000631 | https://www.ncbi.nlm.nih.gov/pubmed/2759183 | Milne, G.W.A. (2017) Drugs: Synonyms and Properties, retrieved from: https://books.google.ru/books?id=RlM8DwAAQBAJ

Divaplon is one of a series of imidazopyrimidine derivatives, which are benzodiazepine receptor ligands. This compound exhibits anxiolytic and anticonvulsant activity but little or no sedative/myorelaxant effects. Divaplon occupied a large percentage of benzodiazepine receptors, as measured with an in vivo binding technique, without inducing any deficit in a rotating drum task in mice, and it is suggested that divaplon is a partial agonist at GABA receptors. No significant anticonvulsant tolerance was seen with the divaplon.

Approval Year

PubMed

Title	Date	PubMed
Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.	2008-11	19043571
Pharmacological analysis of the effects of benzodiazepines on punished schedule-induced polydipsia in rats.	2007-02	17218801
Pharmacological properties of GABAA receptors containing gamma1 subunits.	2006-02	16272224
Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit.	2004-10-15	15451405
Benzodiazepine (omega) receptor partial agonists and the acquisition of conditioned fear in mice.	1995-09	8539334
Behavioural effects of novel benzodiazepine (omega) receptor agonists and partial agonists: increases in punished responding and antagonism of the pentylenetetrazole cue.	1995-03	11224318
Full and partial agonism displayed by benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.	1993-07	8392559
2-(oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors.	1991-07	1648620
Lack of anticonvulsant tolerance with RU 32698 and Ro 17-1812.	1989-05-19	2759183

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:25:31 GMT 2025` Edited by `admin` on `Mon Mar 31 18:25:31 GMT 2025`
Record UNII	4AOV43246G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

divaplon [INN]

Preferred Name

English

DIVAPLON

Official Name

English

6-ETHYL-7-METHOXY-5-METHYLIMIDAZO(1,2-A)PYRIMIDIN-2-YL PHENYL KETONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1012