BEFURALINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H20N2O2.ClH
Molecular Weight	356.846
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.O=C(N1CCN(CC2=CC=CC=C2)CC1)C3=CC4=C(O3)C=CC=C4

InChI

InChIKey=GMEYXHHLZUAKDY-UHFFFAOYSA-N

InChI=1S/C20H20N2O2.ClH/c23-20(19-14-17-8-4-5-9-18(17)24-19)22-12-10-21(11-13-22)15-16-6-2-1-3-7-16;/h1-9,14H,10-13,15H2;1H

HIDE SMILES / InChI

Molecular Formula	C20H20N2O2
Molecular Weight	320.385
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4089015 | https://adisinsight.springer.com/drugs/800000674

Originator

Approval Year

PubMed

Title	Date	PubMed
[Open study of befuraline (DIV 154) in 64 depressive patients (author's transl)].	1977	341906
[Synthesis and antidepressive activity study of aryl and heteroaryl carboxamides of benzylpiperazine].	2000 Jul	10915973

Sample Use Guides

In Vivo Use Guide

Befuraline, given in oral doses of between 100 and 300 mg/day improved the HDRS total score and the cognitive disturbances to a significant extent (p less than 0.01) after the first week of the treatment.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:38:38 GMT 2023` Edited by `admin` on `Fri Dec 15 19:38:38 GMT 2023`
Record UNII	4AF205SN5K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BEFURALINE HYDROCHLORIDE

Common Name

English

NSC-312899

Code

English

DIV-154

Code

English

BENZOFURAN-2-YL 4-BENZYLPIPERAZIN-1-YL KETONE HYDROCHLORIDE

Systematic Name

English

BEFURALINE HCL

Common Name

English

DIV 154

Code

English

BEFURALINE HYDROCHLORIDE [MART.]

Common Name

English

Code System Code Type Description

PUBCHEM

73346