CLOBENZOREX

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H18ClN
Molecular Weight	259.774
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H](CC1=CC=CC=C1)NCC2=CC=CC=C2Cl

InChI

InChIKey=LRXXRIXDSAEIOR-ZDUSSCGKSA-N

InChI=1S/C16H18ClN/c1-13(11-14-7-3-2-4-8-14)18-12-15-9-5-6-10-16(15)17/h2-10,13,18H,11-12H2,1H3/t13-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H18ClN
Molecular Weight	259.774
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18500382
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/9987865 | https://www.ncbi.nlm.nih.gov/pubmed/9050090

Clobenzorex is a central stimulant and sympathomimetic used as an anti-obesity drug; an n-substituted amphetamine, which is metabolized to amphethamine. Its actions are like those of dexamphetamine and has been used as a drug of abuse.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Obesity 206 Sources: https://www.omicsonline.org/conference-proceedings/2153-0769.C1.034_008.pdf	Primary		Approved 8583	ASENLIX Approved Use Clobenzorex is a stimulant drug of the phenethylamine and amphetamine chemical classes used as an appetite suppressant. This medication is used in obesity.

C_max

Value	Dose	Co-administered	Analyte	Population
1.777 ng/mL EXPERIMENT https://www.scirp.org/html/12-2500247_29756.htm	60 mg single, oral dose: 60 mg route of administration: Oral experiment type: SINGLE co-administered:		CLOBENZOREX plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3.429 ng/mL EXPERIMENT https://www.scirp.org/html/12-2500247_29756.htm	30 mg single, oral dose: 30 mg route of administration: Oral experiment type: SINGLE co-administered:		CLOBENZOREX plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
17.777 ng × h/mL EXPERIMENT https://www.scirp.org/html/12-2500247_29756.htm	60 mg single, oral dose: 60 mg route of administration: Oral experiment type: SINGLE co-administered:		CLOBENZOREX plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
11.076 ng × h/mL EXPERIMENT https://www.scirp.org/html/12-2500247_29756.htm	30 mg single, oral dose: 30 mg route of administration: Oral experiment type: SINGLE co-administered:		CLOBENZOREX plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
15.002 h EXPERIMENT https://www.scirp.org/html/12-2500247_29756.htm	60 mg single, oral dose: 60 mg route of administration: Oral experiment type: SINGLE co-administered:		CLOBENZOREX plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3.118 h EXPERIMENT https://www.scirp.org/html/12-2500247_29756.htm	30 mg single, oral dose: 30 mg route of administration: Oral experiment type: SINGLE co-administered:		CLOBENZOREX plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
210 mg 3 times / day multiple, oral Higher than recommended Dose: 210 mg, 3 times / day Route: oral Route: multiple Dose: 210 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/3090971/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/3090971/	Disc. AE: Congestive cardiomyopathy... AEs leading to discontinuation/dose reduction: Congestive cardiomyopathy Sources: https://pubmed.ncbi.nlm.nih.gov/3090971/
90 mg single, oral Highest studied dose Dose: 90 mg Route: oral Route: single Dose: 90 mg Sources: http://www.medrech.com/index.php/medrech/article/view/239	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: FASTED Sources: http://www.medrech.com/index.php/medrech/article/view/239	Sources: http://www.medrech.com/index.php/medrech/article/view/239

AEs

AE	Significance	Dose	Population
Congestive cardiomyopathy	Disc. AE	210 mg 3 times / day multiple, oral Higher than recommended Dose: 210 mg, 3 times / day Route: oral Route: multiple Dose: 210 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/3090971/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/3090971/

PubMed

Title	Date	PubMed
Benfluorex and unexplained valvular heart disease: a case-control study.	2010-04-12	20405030
Drugs and dilated cardiomyopathies: A case/noncase study in the French PharmacoVigilance Database.	2010-03	20233200
Role of substance P on histamine H(3) antagonist-induced scratching behavior in mice.	2006-04	16603804
Amphetamine-like stimulant cessation in an abusing patient treated with bupropion.	2004-01	14674962
Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results.	2002-05	12024689
Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives.	2002-04	11897973
Amphetamine, clobenzorex, and 4-hydroxyclobenzorex levels following multidose administration of clobenzorex.	2001-04	11327347
Clobenzorex: evidence for amphetamine-like behavioral actions.	1997-02	9050090

Patents

Sample Use Guides

In Vivo Use Guide

30 mg bid.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:16:20 GMT 2025` Edited by `admin` on `Mon Mar 31 18:16:20 GMT 2025`
Record UNII	4A5352XI2A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SD 271-12

Preferred Name

English

CLOBENZOREX

Official Name

English

BENZENEETHANAMINE, N-((2-CHLOROPHENYL)METHYL)-.ALPHA.-METHYL-, (S)-

Systematic Name

English

Clobenzorex [WHO-DD]

Common Name

English

SD-271-12

Code

English

clobenzorex [INN]

Common Name

English

SD-27112

Code

English

BENZENEETHANAMINE, N-((2-CHLOROPHENYL)METHYL)-.ALPHA.-METHYL-, (.ALPHA.S)-

Common Name

English

CLOBENZOREX [MI]

Common Name

English

(+)-N-(O-CHLOROBENZYL)-.ALPHA.-METHYLPHENETHYLAMINE

Common Name

English

Classification Tree Code System Code

WHO-VATC

QA08AA08