Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C4H5NO4.2Na |
Molecular Weight | 177.0663 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].N[C@@H](CC([O-])=O)C([O-])=O
InChI
InChIKey=XMXOIHIZTOVVFB-JIZZDEOASA-L
InChI=1S/C4H7NO4.2Na/c5-2(4(8)9)1-3(6)7;;/h2H,1,5H2,(H,6,7)(H,8,9);;/q;2*+1/p-2/t2-;;/m0../s1
Molecular Formula | C4H5NO4 |
Molecular Weight | 131.0868 |
Charge | -2 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.worldcat.org/title/fundamentals-of-biochemistry-life-at-the-molecular-level/oclc/910538334Advances in Protein Chemistry (1945), v.2, p.308, retrieved from: https://books.google.ru/books?id=QRyhIaEwrngCCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/15703381 |
https://www.ncbi.nlm.nih.gov/pubmed/3814227 |
https://www.ncbi.nlm.nih.gov/pubmed/16061593
Sources: https://www.worldcat.org/title/fundamentals-of-biochemistry-life-at-the-molecular-level/oclc/910538334Advances in Protein Chemistry (1945), v.2, p.308, retrieved from: https://books.google.ru/books?id=QRyhIaEwrngC
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/15703381 |
https://www.ncbi.nlm.nih.gov/pubmed/3814227 |
https://www.ncbi.nlm.nih.gov/pubmed/16061593
Disodium aspartate is used in organic biosynthesis.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3814227
Curator's Comment: Aspartic acid is produced in the brain and acts as endogenous neurotransmitter.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Q7L266 Gene ID: 80150.0 Gene Symbol: ASRGL1 Target Organism: Homo sapiens (Human) |
|||
Target ID: CHEMBL2094124 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15703381 |
18.4 µM [EC50] | ||
Target ID: P08236 Gene ID: 2990.0 Gene Symbol: GUSB Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/16061593 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as perpetrator
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/23255614/ Page: - |
no |
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/23255614/ Page: - |
no | |||
Page: - |
yes | |||
Page: - |
yes | |||
Page: - |
yes | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/12706335/ Page: - |
yes | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/24147638/ Page: - |
yes |
PubMed
Title | Date | PubMed |
---|---|---|
Ketanserin for the treatment of preeclampsia. | 2001 |
|
Characterization of the protective effects of melatonin and related indoles against alpha-naphthylisothiocyanate-induced liver injury in rats. | 2001 |
|
Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies. | 2001 Feb |
|
Aging-induced changes in 24-h rhythms of mitogenic responses, lymphocyte subset populations and neurotransmitter and amino acid content in rat submaxillary lymph nodes during Freund's adjuvant arthritis. | 2001 Feb |
|
Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology. | 2001 Feb |
|
Factors associated with the risk of liver enzyme elevation in patients with type 2 diabetes treated with a thiazolidinedione. | 2001 Feb |
|
Design, X-ray crystallography, molecular modelling and thermal stability studies of mutant enzymes at site 172 of 3-isopropylmalate dehydrogenase from Thermus thermophilus. | 2001 Feb |
|
Endotoxin clearance and its relation to hepatic and renal disturbances in rats with liver cirrhosis. | 2001 Feb |
|
Severe veno-occlusive disease after allogeneic bone marrow or peripheral stem cell transplantation--role of transjugular intrahepatic portosystemic shunt (TIPS). | 2001 Feb |
|
Extracellular amino acid levels measured with intracerebral microdialysis in the model of posttraumatic epilepsy induced by intracortical iron injection. | 2001 Feb |
|
Serum hepatic biochemical activity in two populations of workers exposed to styrene. | 2001 Feb |
|
DNA-protein crosslinks induced by nickel compounds in isolated rat lymphocytes: role of reactive oxygen species and specific amino acids. | 2001 Feb 1 |
|
Protective effect of stiripentol on acetaminophen-induced hepatotoxicity in rat. | 2001 Feb 1 |
|
Sodium nitroprusside-induced seizures and adenosine release in rat hippocampus. | 2001 Feb 16 |
|
Changes in striatal electroencephalography and neurochemistry induced by kainic acid seizures are modified by dopamine receptor antagonists. | 2001 Feb 16 |
|
Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer's disease. | 2001 Feb 16 |
|
Evidence for microvesicular storage and release of glycine in rodent pinealocytes. | 2001 Feb 16 |
|
A novel osteopontin-like protein is expressed in the trout ovary during ovulation. | 2001 Feb 2 |
|
Covariate effects on the apparent clearance of tacrolimus in paediatric liver transplant patients undergoing conversion therapy. | 2001 Jan |
|
Coagulation profile, hepatic function, and hemodynamics following Fontan-type operations. | 2001 Jan |
|
Comparison of the efficacy and tolerability of fluvastatin extended-release and immediate-release formulations in the treatment of primary hypercholesterolemia: a randomized trial. | 2001 Jan |
|
Maintenance of primary murine hepatocyte functions in multicomponent polymer capsules--in vitro cryopreservation studies. | 2001 Jan |
|
Characterization of peptide substrates and viral enzyme that affect the cleavage site specificity of the human spumaretrovirus proteinase. | 2001 Jan |
|
Structure activity relationship of antiproliferative N-acyl-aspartic acid dimethyl ester. 2. Variation of the aspartyl moiety. | 2001 Jan |
|
Relationship between crevicular aspartate aminotransferase levels and periodontal disease progression. | 2001 Jan |
|
Plasma ascorbate concentrations are not correlated with milk somatic cell count and metabolic profile in lactating and dry cows. | 2001 Jan |
|
Use of intraosseous blood for repeated hematologic and biochemical analyses in healthy pigs. | 2001 Jan |
|
Chloroplast genetic engineering. | 2001 Jan |
|
The effect of cyclooxygenase-2 inhibitor FK3311 on ischemia-reperfusion injury in a canine total hepatic vascular exclusion model. | 2001 Jan |
|
Oxygen free radical generation in healthy blood donors and cardiac patients: the protective effect of allopurinol. | 2001 Jan |
|
Leukocyte filtration in the early reperfusion phase on cardiopulmonary bypass reduces myocardial injury. | 2001 Jan |
|
Elevation of hepatic transaminases after enoxaparin use: case report and review of unfractionated and low-molecular-weight heparin-induced hepatotoxicity. | 2001 Jan |
|
The effect of amino acid-modifying reagents on chloroplast protein import and the formation of early import intermediates. | 2001 Jan |
|
Ehlers-Danlos syndrome type IV with a unique point mutation in COL3A1 and familial phenotype of myocardial infarction without organic coronary stenosis. | 2001 Jan |
|
Effects of aflatoxin and carotenoids on growth performance and immune response in mule ducklings. | 2001 Jan |
|
Propylene glycol toxicosis in a llama. | 2001 Jan 15 |
|
The effect of ketamine hydrochloride anesthesia on basal and N-methyl-D,L-aspartate induced plasma prolactin secretion in the adult male rhesus monkey. | 2001 Jan 19 |
|
Three-dimensional structure of Erwinia chrysanthemi pectin methylesterase reveals a novel esterase active site. | 2001 Jan 26 |
|
Simplified technique of orthotopic liver transplantation in pigs. | 2001 Jan 27 |
|
Positive and negative strands of HCV-RNA in sera and peripheral blood mononuclear cells of chronically hemodialyzed patients. | 2001 Jan-Feb |
|
Characterization, amino acid sequence and evolution of edema-inducing, basic phospholipase A2 from Trimeresurus flavoviridis venom. | 2001 Jul |
|
The effect of repeated gavage doses of fumonisin B1 on the sphinganine and sphingosine levels in vervet monkeys. | 2001 Jul |
|
Serum hyaluronic acid as an early prognostic marker in biliary atresia. | 2001 Mar |
|
Metabolic changes after cardiac surgery. | 2001 Mar |
|
Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population. | 2001 Mar |
|
Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. | 2001 Mar 1 |
|
In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis. | 2001 Mar 1 |
|
Site-directed mutations in the mitochondrially encoded subunits I and III of yeast cytochrome oxidase. | 2001 Mar 1 |
|
Differential effects of endomorphin-1 and -2 on amphetamine sensitization: neurochemical and behavioral aspects. | 2001 Mar 1 |
|
Pathobiochemical mechanisms involved in the control of the disease caused by Trypanosoma congolense in African grey duiker (Sylvicapra grimmia). | 2001 Mar 5 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3814227
Aspartic acid is a nutrient component found in animal and vegetable sources. In clinical trials to alleviate opioid abstinence it was administered orally.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15703381
Activation of recombinant NMDA receptors was measured using two-electrode voltage clamp. Current and voltage electrodes were made from thin-walled borosilicate glass using a PP-830 electrode puller and when filled with 3 M KCl, possessed resistances of between 0.5 and 1.5 MΩ. Oocytes were voltage-clamped at potentials of -40 mV. Aspartate was able to activate wild type NR1/NR2A NMDA receptors with EC50 of 18.4 uM.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:48:22 GMT 2023
by
admin
on
Fri Dec 15 19:48:22 GMT 2023
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Record UNII |
48MC6MXP9X
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Record Status |
Validated (UNII)
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Record Version |
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